Enhancement of In Vitro Hair Shaft Elongation in Follicles Stored in Buffers That Prevent Follicle Cell Apoptosis

Krugluger, Walter; Moser, Karl; Moser, Claudia; Laciak, Katharina; Hugeneck, Joerg

doi:10.1111/j.1524-4725.2004.30010.x

Cited by 12 publications

(6 citation statements)

References 29 publications

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“…Since Krugluger et al 2 as described the presence of apoptosis and Crisóstomo 3 revealed the relevance of oxidative stress in hair transplant grafts, the ingredients BMOV and monohydroxy ethylrutoside could have beneficial effects on the viability of the grafts. Lebeau et al 8 and Ortolani et al 9 revealed that different flavonoids, such as rutosides, have beneficial effects on ischemia and reperfusion injury.…”

Section: Discussionmentioning

confidence: 99%

“…2 Crisóstomo 3 described the presence of oxidative stress in hair transplants. These studies showed that hair transplantation grafts are vulnerable, but do not reveal that in conventional hair transplantation procedures, the preservation solution is essential, since grafts, usually stored for a minimum period of 2 hours in saline solution before implantation, will regenerate new hairs.…”

mentioning

confidence: 99%

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The Influence of Preservation Solution on the Viability of Grafts in Hair Transplantation Surgery

Gho

Neumann

2013

Plastic and Reconstructive Surgery Global Open

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Summary:Hair transplantation techniques have changed in the last decades. Partial longitudinal follicular unit transplantation is a new hair transplantation technique, which differs from all other hair transplantation techniques by the size of the graft and therefore much more vulnerable grafts compared to the conventional hair transplantation grafts. In this study, we reveal the influence of the preservation solution on the viability of the grafts. We have extracted 15 hair transplantation grafts of 0.6 mm and 15 hair transplantation grafts of 0.7 mm from 3 different patients and investigated the influence of 2 commercially available preservation media, saline solution (Braun, Melsungen, Germany) and Ringer’s lactate (Braun), on the viability of grafts and compared these solutions with the preservation solution developed by Hair Science Institute with trypan blue. The grafts stored in the preservation solution developed by Hair Science Institute showed a significant better viability compared with the 2 commercially available preservation media saline solution and Ringer’s lactate. This study shows that a preservation solution could influence the viability of the grafts which could be essential for hair transplantations with small grafts such as in partial longitudinal follicular unit transplantation.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

The Influence of Preservation Solution on the Viability of Grafts in Hair Transplantation Surgery

Gho

Neumann

2013

Plastic and Reconstructive Surgery Global Open

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“…Studies by Krugluger et al have shown that using antioxidants and various buffers can markedly reduce shedding of transplanted hair post-operatively, and growth is improved. 35 …”

Section: Donor Area Challengesmentioning

confidence: 99%

Hair restoration surgery: challenges and solutions

Rose¹

2015

CCID

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Hair loss is a common problem affecting both men and women. The most frequent etiology is androgenetic alopecia, but other causes of hair loss such as trauma, various dermatologic diseases, and systemic diseases can cause alopecia. The loss of hair can have profound effects on one’s self esteem and emotional well-being, as one’s appearance plays a role in the work place and interpersonal relationships. It is therefore not surprising that means to remedy hair loss are widely sought. Hair transplant surgery has become increasingly popular, and the results that we are able to create today are quite remarkable, providing a natural appearance when the procedure is performed well. In spite of this, hair transplant surgery is not perfect. It is not perfect because the hair transplant surgeon is still faced with challenges that prevent the achievement of optimal results. Some of these challenges include a limit to donor hair availability, hair survival, and ways to conceal any evidence of a surgical procedure having taken place. This article examines some of the most important challenges facing hair restoration surgery today and possible solutions to these challenges.

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“…Krugluger et al . [13] demonstrated a dramatic rise in cytoplasmic histone-associated DNA fragments (cHADF) after 36 h of culture in serum-containing DMEM culture media. In addition, cHADF was significantly reduced by storage in media containing antioxidants.…”

Section: Ischaemia–reperfusion Injurymentioning

confidence: 99%

“…Krugluger[18] found that grafts stored for 5 h in DMEM with AMG at 10 µg/mL resulted in a significant increase in HSE. AMG added to PBS showed no effect.…”

Section: Ischaemia–reperfusion Injurymentioning

confidence: 99%