Enhancement of Immune Response of Murine Peyer's Patches by a Diet Supplemented With Yogurt

Simone, Claudio De; Veselý, Radek; Negri, Rossella; Salvadori, B. Bianchi; Zanzoglu, S.; Cilli, Audrey; Lucci, L.

doi:10.3109/08923978709035203

Cited by 52 publications

(23 citation statements)

References 6 publications

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“…It is possible that when present in large numbers, LAB or their products are able to gain access to the gut-associated lymphoid tissue, especially Peyer's patches and/or to the systemic immune system. The ability of Peyer's patches cells to produce specific antibodies to LAB (Yasui et al 1989) and to exhibit increased proliferative responses to T-and B-cell mitogens (De Simone et al 1987), and the translocation of LAB to mesenteric lymph nodes and Peyer's patches of mice orally administered with LAB (Claassen et al 1995) support this possibility. Furthermore, the intestinal epithelium contains a variety of immunoregulatory cells (Lefrancois, 1994) and thus the possibility that LAB and their products may exert their influence through these cells also exists.…”

mentioning

confidence: 64%

Enhancement of natural and acquired immunity byLactobacillus rhamnosus(HN001),Lactobacillus acidophilus(HN017) andBifidobacterium lactis(HN019)

Gill

Rutherfurd

Prasad³

et al. 2000

Br J Nutr

324

226

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Consumption of lactic acid bacteria (LAB) has been suggested to confer a range of health benefits including stimulation of the immune system and increased resistance to malignancy and infectious illness. In the present study, the effects of feeding Lactobacillus rhamnosus (HN001, DR20 TM ), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019, DR10 TM ) on in vivo and in vitro indices of natural and acquired immunity in healthy mice were examined. Mice were fed daily with L. rhamnosus, L. acidophilus or B. lactis (10 9 colony forming units) and their immune function was assessed on day 10 or day 28. Supplementation with L. rhamnosus, L. acidophilus or B. lactis resulted in a significant increase in the phagocytic activity of peripheral blood leucocytes and peritoneal macrophages compared with the control mice. The proliferative responses of spleen cells to concanavalin A (a T-cell mitogen) and lipopolysaccharide (a B-cell mitogen) were also significantly enhanced in mice given different LAB. Spleen cells from mice given L. rhamnosus, L. acidophilus or B. lactis also produced significantly higher amounts of interferon-g in response to stimulation with concanavalin A than cells from the control mice. LAB feeding had no significant effect on interleukin-4 production by spleen cells or on the percentages of CD4 + , CD8 + and CD40 + cells in the blood. The serum antibody responses to orally and systemically administered antigens were also significantly enhanced by supplementation with L. rhamnosus, L. acidophilus or B. lactis. Together, these results suggest that supplementation of the diet with L. rhamnosus (HN001), L. acidophilus (HN017) or B. lactis (HN019) is able to enhance several indices of natural and acquired immunity in healthy mice.

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mentioning

confidence: 64%

Enhancement of natural and acquired immunity byLactobacillus rhamnosus(HN001),Lactobacillus acidophilus(HN017) andBifidobacterium lactis(HN019)

Gill

Rutherfurd

Prasad³

et al. 2000

Br J Nutr

324

226

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“…Beneficial members of the gut microbiota bacteria may also cross the intestinal barrier into the Peyer's patches (PP), and activate immune cells there (29) . Others suggest that it is not the beneficial bacteria themselves that cross the barrier, but microbial substances such as cell wall components and cytoplasmic antigens (30) . Bifidobacterium species and Lactobacillius species are able to produce antibacterial substances that can inhibit the growth and survival of pathogens (31) .…”

Section: Dietary Sources Of Prebioticsmentioning

confidence: 99%

Prebiotics, immune function, infection and inflammation: a review of the evidence

2008

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b2-1 Fructans are carbohydrate molecules with prebiotic properties. Through resistance to digestion in the upper gastrointestinal tract, they reach the colon intact, where they selectively stimulate the growth and/or activity of beneficial members of the gut microbiota. Through this modification of the intestinal microbiota, and by additional mechanisms, b2-1 fructans may have beneficial effects upon immune function, ability to combat infection, and inflammatory processes and conditions. In this paper, we have collated, summarised and evaluated studies investigating these areas. Twenty-one studies in laboratory animals suggest that some aspects of innate and adaptive immunity of the gut and the systemic immune systems are modified by b2-1 fructans. In man, two studies in children and nine studies in adults indicate that the adaptive immune system may be modified by b2-1 fructans. Thirteen studies in animal models of intestinal infections conclude a beneficial effect of b2-1 fructans. Ten trials involving infants and children have mostly reported benefits on infectious outcomes; in fifteen adult trials, little effect was generally seen, although in specific situations, certain b2-1 fructans may be beneficial. Ten studies in animal models show benefit of b2-1 fructans with regard to intestinal inflammation. Human studies report some benefits regarding inflammatory bowel disease (four positive studies) and atopic dermatitis (one positive study), but findings in irritable bowel syndrome are inconsistent. Therefore, overall the results indicate that b2-1 fructans are able to modulate some aspects of immune function, to improve the host's ability to respond successfully to certain intestinal infections, and to modify some inflammatory conditions. b2-1 Fructans: Inulin: Oligofructose: Fructo-oligosaccharides: Cytokines Prebiotics have been defined as 'non-digestible food ingredients that beneficially affect the host by selectively stimulating the growth, and/or activity, of one or a limited number of beneficial bacteria in the colon and thus improve host health' (1) . Research on the potential health benefits of prebiotics has occurred over the last 15 years or so, with a recent interest in the effects on the immune system, the host's ability to fight infection, and inflammatory processes and conditions. These effects have been reviewed several times (2 -7) but to our knowledge there are no reviews that bring together all of the available studies in all of the these areas. Thus, the aim of the present article is to describe the structure and dietary sources of prebiotics, and to summarise and evaluate studies investigating the influence of prebiotics on immunity, host defence, and inflammatory processes and conditions.Structure of prebiotics b2-1 Fructans, which include inulin (IN) and fructo-oligosaccharides (FOS), fulfil the criteria for prebiotics (8) . Other carbohydrates including galacto-oligosaccharides (GOS), gluco-oligosaccharides, isomalto-oligosaccharides, lactulose, mannanoligosaccharides (MOS), nigero-oli...

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“…Oral administration to mice of milk containing L. bulgaricus or L. casei has been shown to activate the lymphocytes and macrophages (Perdigon et al, 1999). Addition of yoghurt to cultures of human blood lymphocytes stimulated by a mutagen leads to increased production of gamma-interferon, a cytokine with anti-proliferative properties that is able to activate natural killer (NK) cells (De Simone et al, 1987). The mechanism of intestinal colonisation by lactic acid bacteria has not yet been established, and it is likely that their consumption would have to be very frequent in order to have a significant effect on the intestine.…”

Section: Lactic Acid Bacteriamentioning

confidence: 99%

Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence

2003

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Objectives: This review provides an overview of the principal hypotheses and epidemiological evidence of the possible links between colorectal cancer and intake of milk and=or dairy products. Methods: The first section outlines the main hypotheses about the possible effect of calcium, vitamin D, fats and other milk components. The possible role of acid lactic bateria in fermented products is also discussed. The second section is a summary of the published epidemiological evidence. The results on milk, cheese and yoghurt are summarized using a meta-analytical approach. The results of studies on calcium and vitamin D are briefly described. Results: Case -control studies are heterogeneous and, on average, do not provide evidence of association between total intake of total dairy products, milk, cheese or yoghurt and colorectal cancer risk. The average result from cohort studies support the hypothesis of a protective effect of total dairy products (odds ratio (OR): 0.62; 95% confidence interval (CI): 0.52 -0.74; P heterogeneity test: 0.93) and for milk (OR: 0.80; 95% CI: 0.68 -0.95; P heterogeneity: 0.77). No association was found between cheese (OR: 1.10; 95% CI: 0.88 -1.36; P heterogeneity: 0.55) or yoghurt (OR: 1.03; 95% CI: 0.83 -1.28; P heterogeneity: 0.69) in cohort studies. Conclusions: Cohort studies consistently found a protective effect of total dairy products and milk intake, but the evidence is not supported by case -control studies. No relationship was found with cheese or yoghurt intake. As the number of cohort studies is still limited, their results need to be confirmed by other prospective studies.

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Enhancement of Immune Response of Murine Peyer's Patches by a Diet Supplemented With Yogurt

Cited by 52 publications

References 6 publications

Enhancement of natural and acquired immunity byLactobacillus rhamnosus(HN001),Lactobacillus acidophilus(HN017) andBifidobacterium lactis(HN019)

Enhancement of natural and acquired immunity byLactobacillus rhamnosus(HN001),Lactobacillus acidophilus(HN017) andBifidobacterium lactis(HN019)

Prebiotics, immune function, infection and inflammation: a review of the evidence

Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence

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