Enhancement of hydrosolubility and in vitro antiproliferative properties of chalcones following encapsulation into β-cyclodextrin/cellulose-nanocrystal complexes

Rioux, Benjamin; Ndong-Ntoutoume, Gautier M.A.; Granet, Robert; Gamond, Aurélie; Laurent, Aurélie; Pinon, Aline; Champavier, Yves; Liagre, Bertrand; Fagnere, Catherine; Sol, Vincent

doi:10.1016/j.bmcl.2019.05.056

Cited by 13 publications

(5 citation statements)

References 21 publications

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“… Dispersion, Freeze-drying [ 175 ] (β-CD)-CNC Chalcones Enhanced in vitro antiproliferative activity against colorectal and prostatic cancer cells. Ultra-sonication [ 176 ] (AND)–CNC–MGO Curcumin Dual stimuli-responsive nanoparticle, synergistic therapy against colon cancer cells. Layer-by-layer assembly [ 177 ] CS-PEO-CQDs/CMC-PVA Temozolomide Cytotoxicity of TZM towards U251 cancer cell line Coaxial electrospinning technique [ 165 ] DGN-ALG-Q-NC Pickering emulsion Quinalizarin, diosgenin Excellent stability, high encapsulation, and sustained drug release.…”

Section: Delivery Of Active Molecules/therapeutic Agentsmentioning

confidence: 99%

Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications

Patil

Patel

Dutta

et al. 2022

Bioactive Materials

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Nanocellulose, a biopolymer, has received wide attention from researchers owing to its superior physicochemical properties, such as high mechanical strength, low density, biodegradability, and biocompatibility. Nanocellulose can be extracted from wide range of sources, including plants, bacteria, and algae. Depending on the extraction process and dimensions (diameter and length), they are categorized into three main types: cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial nanocellulose (BNC). CNCs are a highly crystalline and needle-like structure, whereas CNFs have both amorphous and crystalline regions in their network. BNC is the purest form of nanocellulose. The nanocellulose properties can be tuned by chemical functionalization, which increases its applicability in biomedical applications. This review highlights the fabrication of different surface-modified nanocellulose to deliver active molecules, such as drugs, proteins, and plasmids. Nanocellulose-mediated delivery of active molecules is profoundly affected by its topographical structure and the interaction between the loaded molecules and nanocellulose. The applications of nanocellulose and its composites in tissue engineering have been discussed. Finally, the review is concluded with further opportunities and challenges in nanocellulose-mediated delivery of active molecules.

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Section: Delivery Of Active Molecules/therapeutic Agentsmentioning

confidence: 99%

Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications

Patil

Patel

Dutta

et al. 2022

Bioactive Materials

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“…334 This approach was also used to deliver other drugs such as chalcones. 335 Encapsulation into β-CD enhanced the solubility of chalcones and subsequently led to increased drug activity.…”

Section: Host-guest Chemistrymentioning

confidence: 99%

Surface modified cellulose nanomaterials: a source of non-spherical nanoparticles for drug delivery

Khine

Stenzel

2020

Mater. Horiz.

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“…Their privileged structure also opens up possibilities for substitutions in aromatic rings [ 2 ], directly impacting its biological activity and development of formulations capable of improving its pharmacokinetic characteristics [ 3 ]. Due to their high biological value, the literature also reports on the anti-inflammatory [ 4 ], antiviral [ 5 ], antimicrobial [ 6 ], anticancer [ 7 ], antioxidant [ 8 ], and antifungal [ 9 ] properties of these compounds.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to presenting a difficult prognosis, it still has a very aggressive treatment and a high mortality rate, caused both by the disease and by the impacts of its treatment [11]. Natural products such as chalcones of the type (1,3-diaryl-2-propen-1ones) have been the focus of research for the treatment of this disease, as they have a conjugated carbonyl system that acts by inhibiting the polymerization of tubulin in tumor Their privileged structure also opens up possibilities for substitutions in aromatic rings [2], directly impacting its biological activity and development of formulations capable of improving its pharmacokinetic characteristics [3]. Due to their high biological value, the literature also reports on the anti-inflammatory [4], antiviral [5], antimicrobial [6], anticancer [7], antioxidant [8], and antifungal [9] properties of these compounds.…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies

et al. 2023

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Chalcones are direct precursors in the biosynthesis of flavonoids. They have an α,β-unsaturated carbonyl system which gives them broad biological properties. Among the biological properties exerted by chalcones, their ability to suppress tumors stands out, in addition to their low toxicity. In this perspective, the present work explores the role of natural and synthetic chalcones and their anticancer activity in vitro reported in the last four years from 2019 to 2023. Moreover, we carried out a partial least square (PLS) analysis of the biologic data reported for colon adenocarcinoma lineage HCT-116. Information was obtained from the Web of Science database. Our in silico analysis identified that the presence of polar radicals such as hydroxyl and methoxyl contributed to the anticancer activity of chalcones derivatives. We hope that the data presented in this work will help researchers to develop effective drugs to inhibit colon adenocarcinoma in future works.

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Enhancement of hydrosolubility and in vitro antiproliferative properties of chalcones following encapsulation into β-cyclodextrin/cellulose-nanocrystal complexes

Cited by 13 publications

References 21 publications

Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications

Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications

Surface modified cellulose nanomaterials: a source of non-spherical nanoparticles for drug delivery

Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies

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