Enhancement of Human Monocyte and Peritoneal Macrophage Chemiluminescence Activities in Women With Endometriosis

Jm, Zeller; Henig, Israel; Radwańska, Ewa; Dmowski, W. Paul

doi:10.1111/j.1600-0897.1987.tb00097.x

Cited by 142 publications

(67 citation statements)

References 18 publications

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“…IL-1 is a prototypic example of an activated peritoneal macrophage secretory product in endometriosis. Macrophages from women with endometriosis were found to secrete elevated levels of IL-1 (Zeller et al 1987). Elevated concentrations of IL-1 were found in the peritoneal fluid of women suffering from endometriosis (Fakih et al 1987, Mori et al 1992, Taketani et al 1992.…”

Section: Il-1ri Expression In Ectopic Endometrial Tissuementioning

confidence: 96%

Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions

Lawson

Al-Akoum

Maheux³

et al. 2007

Reproduction

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The establishment and progression of ectopic endometrial implants are dependent upon their interaction with and responsiveness to the stimuli present in their new environment. According to our and other previous studies, immune cells-derived cytokines, such as IL-1, may alone or in concert with estrogens, enhance the capability of ectopic endometrial cells to implant and develop into the host tissue. In the present study, immunohistochemical and dual immunofluorescence analyses showed that the functional signaling interleukin-1 receptor type 1 (IL-1RI) is expressed in endometriotic tissue, particularly in the glands, and identified endothelial cells, macrophages, and T-lymphocytes as cells having marked expression of IL-1RI. The highest concentrations of IL-1RI protein in endometriotic tissue, as evaluated using histological score (HSCORE) and measured by ELISA, were found in red endometriotic lesions as compared with typical black-blue or white lesions. Western blotting showed a significant increase in the levels of the 50 kDa band, whose apparent molecular weight corresponds to the soluble form of IL-1RI. RT-PCR analysis of IL-1 mRNA levels showed a pattern of expression comparable to that of the protein. Interestingly, IL-1RI expression was more significant in the proliferative than in the secretory phase of the menstrual cycle. Marked expression of IL-1RI, the functional signaling receptor that mediates cell activation by IL-1, in red endometriotic implants, which are highly vascularized and represent the earliest and most active forms of the disease, point to a higher cell receptivity for IL-1 in these lesions, a relationship with the activity of the disease and a possible involvement in the early steps of endometriotic tissue growth and development. Reproduction (2007) 133 265-274

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Section: Il-1ri Expression In Ectopic Endometrial Tissuementioning

confidence: 96%

Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions

Lawson

Al-Akoum

Maheux³

et al. 2007

Reproduction

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“…Numerous studies in the past several years have shown that the biochemical signature of peritoneal fluid in patients with endometriosis is more pro-inflammatory compared to healthy women [78]. In women affected with endometriosis, activated macrophages in the peritoneal cavity are more abundant compared to their healthy counterparts [79][80][81]. Peritoneal fluid of women with this condition imposes a significant inhibitory effect on ciliary beat frequency [82].…”

Section: Endometriosismentioning

confidence: 99%

Tubal transport of gametes and embryos: a review of physiology and pathophysiology

Ezzati

Djahanbakhch

Arian³

et al. 2014

J Assist Reprod Genet

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With the advent of assisted reproductive technology in the past three decades, the clinical importance of fallopian tubes has been relatively overlooked. However, successful spontaneous conception requires normal function of the tube to provide not only a conduit for the gametes to convene and embryo to reach the uterine cavity, but also a physiologically optimized environment for fertilization and early embryonic development. In this review, after a brief description of normal human tubal anatomy and histology, we will discuss tubal transport and its principal effectors, including ciliary motion, muscular contractility and tubal fluid. Furthermore, we will discuss the ciliary ultrastructure and regulation of ciliary beat frequency by ovarian steroids, follicular fluid, angiotensin system, autonomic nervous system and other factors such as adrenomedullin and prostaglandins. In the last section, we describe the adverse impact of various pathological conditions, such as endometriosis, infection and smoking on tubal function and ciliary motility.

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“…IL-1 may also play an important role in the pathophysiology of endometriosis, a gynecological disease that is associated with a chronic immunoinflammatory process (30 -32). In women with endometriosis, peripheral blood monocytes (33), as well as peritoneal macrophages (34), were found to be more activated than in normal women and to secrete elevated levels of IL-1. Increased concentrations of IL-1 were detected in the peritoneal fluid of women suffering from endometriosis (33)(34)(35).…”

Section: Il-1␤-mediated Proinflammatory Responsesmentioning

confidence: 99%

IL-1β-Mediated Proinflammatory Responses Are Inhibited by Estradiol via Down-Regulation of IL-1 Receptor Type I in Uterine Epithelial Cells

Schaefer

Wright

Pioli

et al. 2005

The Journal of Immunology

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The objective of this study was to examine the effects of sex hormones on IL-1β-mediated responses by uterine epithelial cells. The mRNA expression and secretion of human β-defensin-2 and CXCL8 by uterine epithelial cells was examined following stimulation with IL-1β in the presence of estradiol or progesterone. Estradiol inhibited the IL-1β-mediated mRNA expression and secretion of human β-defensin-2 and CXCL8 by uterine epithelial cells while progesterone had no effect. Inhibition of the IL-1β-mediated response by estradiol was dose dependent, with maximal inhibition observed using 10−7 to 10−10 M, and was shown to be mediated through the estrogen receptor because addition of a pure estrogen receptor antagonist abrogated this effect. The mechanism by which estradiol inhibits IL-1β-mediated responses by uterine epithelial cells appears to be the down-modulation of the IL-1R type I, thereby reducing the uterine epithelial cell’s ability to respond to IL-1β. These results suggest that the inhibitory effect of estradiol on IL-1β-mediated inflammatory responses by uterine epithelial cells indicates a link between the endocrine and immune systems and may be crucial for dampening proinflammatory responses during the time of ovulation or pregnancy.

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Enhancement of Human Monocyte and Peritoneal Macrophage Chemiluminescence Activities in Women With Endometriosis

Cited by 142 publications

References 18 publications

Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions

Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions

Tubal transport of gametes and embryos: a review of physiology and pathophysiology

IL-1β-Mediated Proinflammatory Responses Are Inhibited by Estradiol via Down-Regulation of IL-1 Receptor Type I in Uterine Epithelial Cells

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