Enhancement of host resistance against<i>Salmonella typhimurium</i>infection by a diet supplemented with yogurt

Simone, Claudio De; Tzantzoglou, Sonia; Baldinelli, L.; Fabio, Simonetta Di; Bianchi-Salvadori, B.; Jirillo, Emilio; Veselý, Radek

doi:10.3109/08923978809041429

Cited by 45 publications

(17 citation statements)

References 18 publications

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“…These results suggest that continuous ingestion of PFH can stimulate activation or antigen presentation in a phagocyte, thus enhancing the immune function of the body. This is consistent with a previous report demonstrating that dietary administration of Ulgum can increase the phagocytic activity of macrophages in mice [2] and supports previous reports that Maesil [29,34], Bokbunja [20] and some probiotics [8,25,30] have potential antimicrobial effects against a number of pathogens.…”

Section: Discussionsupporting

confidence: 93%

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Dietary Supplementation with a Probiotic Fermented Four-Herb Combination Enhances Immune Activity in Broiler Chicks and Increases Survivability against Salmonella Gallinarum in Experimentally Infected Broiler Chicks

Jung

Lee

2010

The Journal of Veterinary Medical Science

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ABSTRACT. Herbs including Curcuma longa, Houttuynia cordata, Prunus mume and Rubus coreanus have potential immune enhancing and antimicrobial effects. Probiotics also have antibacterial effects, and some are important in regulating the immune system. The aims of the present study were to evaluate the immune enhancing effects of a probiotic fermented four-herb combination (PFH) in broiler chicks and to demonstrate the prophylactic effect of PFH against Salmonella Gallinarum in experimentally infected broiler chicks as an initial step towards the development of feed supplements for promotion of immune activity and disease prevention. Continuous ingestion of PFH markedly increased lysozyme activity in serum and the spleen, peripheral blood mononuclear cell (PBMC) proliferation, the CD4 + :CD8 + T lymphocyte ratio in the spleen and antibody production level in broiler chicks. Conversely, prostaglandin E 2 synthesis in serum and PBMC culture medium was significantly decreased in the PFH-fed chicks compared with the control group in a dose-dependent manner. In the chicks experimentally infected with S. Gallinarum, mortality was delayed in the 2% PFH-fed chicks. Moreover, the survival rates in the 2% PFH-fed group remained the highest among all the trial groups throughout the experimental period. Taken together, these findings suggest that PFH enhances immune activity in broiler chicks and increases survivability against Salmonella Gallinarum in experimentally infected broiler chicks, likely because of potent stimulation of nonspecific immune responses.

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Section: Discussionsupporting

confidence: 93%

“…Probiotics such as Lactobacillus and Streptococci activate the NF-kappa B and STAT signaling pathways in human macrophages [27]. Moreover, they have potential antimicrobial effects against several pathogens including Listeria monocytogenes [30], Salmonella Typhimurium [8] and Escherichia coli [25].…”

mentioning

confidence: 99%

Dietary Supplementation with a Probiotic Fermented Four-Herb Combination Enhances Immune Activity in Broiler Chicks and Increases Survivability against Salmonella Gallinarum in Experimentally Infected Broiler Chicks

Jung

Lee

2010

The Journal of Veterinary Medical Science

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“…bulgaricus, and S. thermophilus all suppressed the proliferation of human PBMC induced with a very high concentration (125 µg/mL) of PHA (66). This effect was significantly reduced, but not completely eliminated, by heat inactivation.…”

Section: Other Effects Of Lab On Immune Functionsmentioning

confidence: 79%

The influence of yogurt/lactobacillus on the innate and acquired immune response

Borchers

Keen

Gershwin

2002

Clinic Rev Allerg Immunol

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“…Lactic acid bacteria have all these characteristics, are not enteropathogenic or enterotoxigenic and are known for their ability to suppress the growth of species of enteric bacteria in vitro (4)(5)(6). Although physiological conditions in vivo are vastly different from in vitro model systems used for most studies, the presence of lactic acid bacteria in the intestine is postulated to limit the growth, metabolism or survival of other enteric bacteria, which may in turn limit pathogenic or toxigenic effects (7)(8)(9). Many other biological effects have been attributed to lactic acid bacteria, such as bile salt deconjugation (10), induction of higher tolerance to lactose when given to lactoseintolerant subjects (11,12), anticholesterolemic effects (13)(14)(15) and anticarcinogenic properties (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Monoassociation with Lactobacillus acidophilus UFV-H2b20 stimulates the immune defense mechanisms of germfree mice

Neumann¹,

Oliveira²,

Cabral³

et al. 1998

Braz J Med Biol Res

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Probiotics are formulations containing live microorganisms or microbial stimulants that have some beneficial influence on the maintenance of a balanced intestinal microbiota and on the resistance to infections. The search for probiotics to be used in prevention or treatment of enteric infections, as an alternative to antibiotic therapy, has gained significant impulse in the last few years. Several studies have demonstrated the beneficial effects of lactic acid bacteria in controlling infection by intestinal pathogens and in boosting the hosts nonspecific immune response. Here, we studied the use of Lactobacillus acidophilus UFV-H2b20, a lactic acid bacterium isolated from a human newborn from Viçosa, Minas Gerais, Brazil, as a probiotic. A suspension containing 10 8 cells of Lactobacillus acidophilus UFV-H2b20 was inoculated into groups of at least five conventional and germfree Swiss mice to determine its capacity to stimulate the host mononuclear phagocytic activity. We demonstrate that this strain can survive the stressing conditions of the intestinal tract in vivo. Moreover, the monoassociation of germfree mice with this strain for seven days improved the hosts macrophage phagocytic capacity, as demonstrated by the clearance of a Gram-negative bacterium inoculated intravenously. Monoassociated mice showed an undetectable number of circulating E. coli, while 0.1% of the original inoculum was still present in germfree animals. Mice treated with viable or heat-killed Lactobacillus acidophilus UFV-H2b20 presented similarly improved clearance capacity when compared with germfree controls. In addition, monoassociated mice had twice the amount of Kupffer cells, which are responsible for the clearance of circulating bacteria, compared to germfree controls. These results suggest that the L. acidophilus strain used here stimulates a nonspecific immune response and is a strong candidate to be used as a probiotic.

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Enhancement of host resistance againstSalmonella typhimuriuminfection by a diet supplemented with yogurt

Cited by 45 publications

References 18 publications

Dietary Supplementation with a Probiotic Fermented Four-Herb Combination Enhances Immune Activity in Broiler Chicks and Increases Survivability against Salmonella Gallinarum in Experimentally Infected Broiler Chicks

Dietary Supplementation with a Probiotic Fermented Four-Herb Combination Enhances Immune Activity in Broiler Chicks and Increases Survivability against Salmonella Gallinarum in Experimentally Infected Broiler Chicks

The influence of yogurt/lactobacillus on the innate and acquired immune response

Monoassociation with Lactobacillus acidophilus UFV-H2b20 stimulates the immune defense mechanisms of germfree mice

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