Enhancement of hepatoprotective activity of limonin from citrus seeds against acetaminophen-induced liver injury by HSCCC purification and liposomal encapsulation

Yang, Wanling; Liang, Yiyao; Liu, Yujie; Yao, Yunan; Yu, Zhiqian; Chen, Baizhong; Cai, Yi; Wei, Minyan; Zheng, Guodong

doi:10.1016/j.fitote.2024.105899

Cited by 1 publication

(1 citation statement)

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“…Among these extraction technologies, ultrasonic-assisted extraction is widely used for the extraction of triterpenoids due to its simplicity, rapidity, and high efficiency [23]. The separation and purification techniques for triterpenoids mainly include column chromatography on silica gel [24], thin-layer chromatography [25], high-speed countercurrent chromatography [26], macroporous resin adsorber chromatography [27], and recrystallization [28]. Macroporous resin adsorber chromatography is often used for the separation and purification of triterpenoids and has the advantages of reusability, low price, good adsorption efficiency, and fast exchange rate [29,30].…”

Section: Introductionmentioning

confidence: 99%

Optimization of the Extraction Process and Biological Activities of Triterpenoids of Schisandra sphenanthera from Different Medicinal Parts and Growth Stages

Zhao,

Li,

Shang

et al. 2024

Molecules

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Schisandra sphenanthera Rehd. et Wils., as a traditional Chinese medicine, has important medicinal value. In the market, the availability of the fruit of S. sphenanthera mainly relies on wild picking, but many canes and leaves are discarded during wild collection, resulting in a waste of resources. The canes and leaves of S. sphenanthera contain various bioactive ingredients and can be used as spice, tea, and medicine and so present great utilization opportunities. Therefore, it is helpful to explore the effective components and biological activities of the canes and leaves to utilize S. sphenanthera fully. In this study, the response surface method with ultrasound was used to extract the total triterpenoids from the canes and leaves of S. sphenanthera at different stages. The content of total triterpenoids in the leaves at different stages was higher than that in the canes. The total triterpenoids in the canes and leaves had strong antioxidant and antibacterial abilities. At the same time, the antibacterial activity of the total triterpenoids against Bacillus subtilis and Pseudomonas aeruginosa was stronger than that against Staphylococcus aureus and Escherichia coli. This study provides the foundation for the development and utilization of the canes and leaves that would relieve the shortage of fruit resources of S. sphenanthera.

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