Enhancement of Hepatic Hemangiomas With Levovist on Coded Harmonic Angiographic Ultrasonography

Kim, Jung Hoon; Kim, Tae Kyoung; Kim, Bong Soo; Eun, Hyo Won; Kim, Pyo Nyun; Lee, Moon-Gyu; Ha, Hyun Kwon

doi:10.7863/jum.2002.21.2.141

Cited by 21 publications

(20 citation statements)

References 17 publications

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“…To overcome the shortcomings of conventional harmonic imaging, various gray-scale harmonic imaging techniques have recently been developed (5, 7, 8, 11-13). Among these, digitally encoded harmonic US is the one that encodes the unwanted fundamental frequency component when transmitting pulses and then, through a decoding process when receiving signals, removes the pre-tagged fundamental echo without the loss of overlapping harmonic signals (14). The B-flow technique, optimized for direct visualization of blood cells at gray-scale imaging, uses codes to enhance weak blood echoes and equalize a non-moving tissue signal (15), and is thus free of Doppler artifact.…”

Section: Discussionmentioning

confidence: 99%

Focal Hepatic Lesions: Evaluation with Contrast-Enhanced Gray-Scale Harmonic US

et al. 2003

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ObjectiveTo determine the findings of various focal hepatic lesions at contrast-enhanced gray-scale ultrasound (US) using a coded harmonic angio (CHA) technique and emphasizing lesion characterization.Materials and MethodsThe study involved 95 patients with 105 focal hepatic lesions, namely 51 hepatocellular carcinomas (HCCs), 22 metastases, 22 hemangiomas, four cases of focal nodular hyperplasia (FNH), and six nontumorous nodules. After the injection of a microbubble contrast agent (SH U 508A), gray-scale harmonic US studies using a CHA technique were performed with a combination of continuous scanning to assess the intratumoral vasculature (vascular imaging) and interval-delay scanning to determine the sequential enhancement pattern (acoustic emission imaging). Each imaging pattern was categorized and analyzed.ResultsAt vascular imaging, 69% of HCCs (35/51) showed irregular branching vessels, while in 91% of metastases (20/22) a peripherally stippled pattern was observed. Intratumoral vessels were absent in 95% of hemangiomas (21/22) and all nontumorous lesions (6/6), while in 75% of FNHs (3/4) a spoke-wheel pattern was evident. At acoustic emission imaging, 71% of HCCs (36/51) showed heterogeneous enhancement and 86% (19/22) of metastases showed rim- or flame-like peripheral enhancement during the early phase, with washout occurring in all HCCs and metastases (100%, 73/73) during the late phase. In hemangiomas, enhancement was either peripheral and nodular (19/22, 86%) or persistent and homogeneous (3/22, 14%), and 75% of FNHs (3/4) became isoechoic during the late phase.ConclusionAt contrast-enhanced gray-scale US using a CHA technique, a period of continuous scanning depicted the intratumoral vasculature, and interval-delay scanning demonstrated the sequential enhancement pattern. The characteristic findings of various focal hepatic lesions were thus determined.

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Section: Discussionmentioning

confidence: 99%

Focal Hepatic Lesions: Evaluation with Contrast-Enhanced Gray-Scale Harmonic US

et al. 2003

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“…It has been shown that lots of liver lesions show characteristic enhancement patterns on contrast-enhanced gray-scale ultrasonography. The most common enhancement pattern of hepatic hemangioma on contrast-enhanced harmonic US was peripheral globular enhancement with progressive centripetal fill-in (Kim et al, 2002;Ding et al, 2005). Centrifugal filling was the specific enhancement feature of focal nodular hyperplasia (Kim et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Hepatic Angiomyolipoma: Contrast Patterns with SonoVue-enhanced Real-time Gray-scale Ultrasonography

Wei

Wang²,

Ding³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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This study was conducted to retrospectively evaluate the pattern of contrast enhancement with SonoVue on gray-scale ultrasonography of hepatic angiomyolipoma (HAML). Imaging features of 33 pathologically proven HAML lesions in 33 patients who underwent baseline ultrasound and contrast-enhanced ultrasonography (CEUS) were assessed retrospectively. All lesions were enhanced in the arterial phase and showed whole-tumor filling in. Thirty-two of 33 (97%) lesions showed early positive enhancement in the arterial phase. Twenty-three of these exhibited isoechoic or hyperechoic features in the portal phase. HAML demonstrate characteristic manifestations with SonoVue-enhanced real-time gray-scale ultrasonography.

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“…CHA uses the B-flow technique, as well as digitally coded harmonic imaging. The B-flow technique, which is optimized for the direct visualization of blood cells on gray-scale images, uses codes to enhance weak blood echoes and equalize the non-moving tissue signal (19) Thus, the B-flow technique is free of Doppler-related artifacts. By combining the benefits of these two techniques, CHA allows the harmonic signals resulting from tissue to be separated from those arising from contrast agents, and boosts the harmonic return from the contrast agents, while suppressing not only the fundamental, but also the harmonic signals from the background tissue (18-20).…”

Section: Contrast-enhanced Usmentioning

confidence: 99%

Radiofrequency Ablation of Liver Cancer: Early Evaluation of Therapeutic Response with Contrast-Enhanced Ultrasonography

et al. 2004

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The early assessment of the therapeutic response after percutaneous radiofrequency (RF) ablation is important, in order to correctly decide whether further treatment is necessary. The residual unablated tumor is usually depicted on contrast-enhanced multiphase helical computed tomography (CT) as a focal enhancing structure during the arterial and portal venous phases. Contrast-enhanced color Doppler and power Doppler ultrasonography (US) have also been used to detect residual tumors. Contrast-enhanced gray-scale US, using a harmonic technology which has recently been introduced, allows for the detection of residual tumors after ablation, without any of the blooming or motion artifacts usually seen on contrast-enhanced color or power Doppler US. Based on our experience and reports in the literature, we consider that contrast-enhanced gray-scale harmonic US constitutes a reliable alternative to contrast-enhanced multiphase CT for the early evaluation of the therapeutic response to RF ablation for liver cancer. This technique was also useful in targeting any residual unablated tumors encountered during additional ablation.

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Enhancement of Hepatic Hemangiomas With Levovist on Coded Harmonic Angiographic Ultrasonography

Abstract: Coded harmonic angiographic ultrasonography with a microbubble contrast agent can depict the typical enhancement pattern in most hepatic hemangiomas.

Cited by 21 publications

References 17 publications

Focal Hepatic Lesions: Evaluation with Contrast-Enhanced Gray-Scale Harmonic US

Focal Hepatic Lesions: Evaluation with Contrast-Enhanced Gray-Scale Harmonic US

Hepatic Angiomyolipoma: Contrast Patterns with SonoVue-enhanced Real-time Gray-scale Ultrasonography

Radiofrequency Ablation of Liver Cancer: Early Evaluation of Therapeutic Response with Contrast-Enhanced Ultrasonography

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