Enhancement of graphene quantum dots based applications via optimum physical chemistry: A review

Jegannathan, Pushpa; Yousefi, Amin; Karim, Mohd Sayuti Abd; Kadri, Nahrizul Adib

doi:10.1016/j.bbe.2018.03.006

Cited by 29 publications

(16 citation statements)

References 92 publications

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“…Graphene or graphene-based nanomaterials [ 145 , 172 ] have been reported for drug delivery and release in order to improve delivery efficiency and enhance therapeutic effects [ 143 , 171 – 174 ]. Compared with graphene, GQDs have better water solubility, lower cytotoxicity [ 61 , 150 , 175 , 176 ], and larger specific surface area, which makes them more effective drug molecular loading cores [ 12 , 177 , 178 ].…”

Section: Applications Of Gqds In Drug Deliverymentioning

confidence: 99%

Synthesis of graphene quantum dots and their applications in drug delivery

et al. 2020

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This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.

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Section: Applications Of Gqds In Drug Deliverymentioning

confidence: 99%

Synthesis of graphene quantum dots and their applications in drug delivery

et al. 2020

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“…16 Recently, GQDs have attracted significant attention owing to their exceptional properties, including excellent solubility, improved electrical and optical properties related to the quantum confinement, and edge effects. 17 The surface of GQDs can be substantially modified by heteroatom doping (N, O, S, etc.) of different functional groups such as amine, hydroxyl, thiol, and carboxylic groups, etc., which enhance the number of active sites.…”

Section: ■ Introductionmentioning

confidence: 99%

Fluorescent N-Doped Graphene Quantum Dots Embedded in Transparent Polymer Films for Photon-Downconversion Applications

Nazim

Kim

2020

ACS Appl. Nano Mater.

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In this work, we demonstrate a simple, facile, and efficient onepot synthesis of polymer−quantum dot nanocomposite films where nitrogendoped graphene quantum dots (N-GQDs) were homogeneously dispersed in UV-curable, transparent polymer host matrix via the thiol−ene "click" reaction pathway. The highly fluorescent NOA−NGQD nanocomposite films exhibited strong hydrophobicity with water contact angle (>69°) owing to restructuring of the polymer chain networks. The various functional groups of the N-GQD surface, as carbonyl, amine, and hydroxyl groups, provided more interactive sites and low agglomeration to develop the strong electrostatic interactions between the NOA and N-GQDs, resulting in flexible NOA−NGQDs nanocomposites. Thus, obtained NOA−NGQD nanocomposites exhibited high transparency (>90%), low band-gap, and strong fluorescence spectral peak (>500 nm) after the homogeneous inclusion of N-GQDs in the NOA polymer matrix. This study paves the way to diverse applications of functionalized GQDs as well as transparent polymers for the development of hydrophobic polymer−QD nanocomposites by using UV catalyzed thiol−ene chemistry. Hence, as synthesized nanocomposite films would be widely applicable in flexible electronic display devices, light emitting diodes (LEDs), and optoelectronic applications.

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“…Graphene quantum dots (GQDs) are a promising new carbon nanomaterial formed by graphene fragments of reduced size which exhibit new characteristics due to quantum confinement phenomena and edge effects. Typically, the GQDs have a diameter below 20 nm with high surface area and presence of a π‐π network conjugated bonds mixed with surface oxygenated groups, inherited from 2D graphene . Biological properties of GQDs such as low toxicity and good biocompatibility increase the applicability of this material in the fields of bioimaging and drug delivery .…”

Section: Introductionmentioning

confidence: 99%

Graphene Quantum Dots Modified Screen‐printed Electrodes as Electroanalytical Sensing Platform for Diethylstilbestrol

et al. 2019

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In present work a simple methodology for electroanalytical sensing of diethylstilbestrol (DES) using graphene quantum dots (GQD) surface modified screen‐printed electrodes (SPE) is reported. GQD was synthesized by simple bottom‐up method based on citric acid pyrolysis at 200 °C and electrodeposited directly at electrode surface under cyclic voltammetric conditions. The obtained GQD presented an average diameter of 7 nm and was characterized by techniques such as transmission and scanning electron microscopy, and electrochemical impedance spectroscopy. The proposed sensor exhibits a linear response from 0.05 to 7.5 μmol L−1, with limit of detection and quantification of 8.8 nmol L−1 and 29.0 nmol L−1, respectively. The repeatability study presented RSD=3.6 % for 6 consecutive measurements using the same electrode surface and the reproducibility study showed RSD=6.6 % for measurements with 6 different electrode surfaces. The proposed sensor was successfully applied for DES determination in synthetic urine and tap water spiked samples and good recoveries were obtained without any sample pre‐treatment, showing its promising analytical performance.

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Enhancement of graphene quantum dots based applications via optimum physical chemistry: A review

Cited by 29 publications

References 92 publications

Synthesis of graphene quantum dots and their applications in drug delivery

Synthesis of graphene quantum dots and their applications in drug delivery

Fluorescent N-Doped Graphene Quantum Dots Embedded in Transparent Polymer Films for Photon-Downconversion Applications

Graphene Quantum Dots Modified Screen‐printed Electrodes as Electroanalytical Sensing Platform for Diethylstilbestrol

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