Enhancement of gastrointestinal absorption of isoliquiritigenin by nanostructured lipid carrier

Zhang, Xiaoyun; Qiao, Hui; Zhang, Taifeng; Shi, Yanbin; Ni, Jingman

doi:10.1016/j.apt.2014.02.012

Cited by 28 publications

(16 citation statements)

References 50 publications

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“…NLCs have gained high recognition as suggested by various research reports published so far for drugs, such as isoliquiritigenin, fenofibrate, baicalin, etc. [23,43,47]. Various mechanisms are proposed in this regard and improved bioavailability can be attributed to the suppressed degradation of drugs in GIT; direct uptake of NLCs in GIT; permeation enhancement effect of surfactants employed in formulating of NLCs or avoidance of first pass metabolism [74].…”

Section: Oral Bioavailability Enhancement By Nlcsmentioning

confidence: 99%

“…Higher diffusion of NLCs across the unstirred water layer of intestine epithelial cells facilitated by the presence of hydrophilic surfactant led to augmented values of AUC in comparison to drug solution. Moreover, the small size of NLCs facilitated bioadhesion to intestine membrane, which lead to higher absorption of NLCs [43]. Also etoposide, a cytotoxic agent whose absorption is poor due to its hydrophilic nature and is also a substrate for P-gp was encapsulated in NLCs to surmount its delivery issues [26].…”

Section: Oral Bioavailability Enhancement By Nlcsmentioning

confidence: 99%

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Nanostructured Lipid Carriers: Versatile Oral Delivery Vehicle

Poonia¹,

Kharb

Lather³

et al. 2016

Future Sci. OA

146

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Oral delivery is the most accepted and economical route for drug administration and leads to substantial reduction in dosing frequency. However, this route still remains a challenge for the pharmaceutical industry due to poorly soluble and permeable drugs leading to poor oral bioavailability. Incorporating bioactives into nanostructured lipid carriers (NLCs) has helped in boosting their therapeutic functionality and prolonged release from these carrier systems thus providing improved pharmacokinetic parameters. The present review provides an overview of noteworthy studies reporting impending benefits of NLCs in oral delivery and highlights recent advancements for developing engineered NLCs either by conjugating polymers over their surface or modifying their charge to overcome the mucosal barrier of GI tract for active transport across intestinal membrane.

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Section: Oral Bioavailability Enhancement By Nlcsmentioning

confidence: 99%

Section: Oral Bioavailability Enhancement By Nlcsmentioning

confidence: 99%

Nanostructured Lipid Carriers: Versatile Oral Delivery Vehicle

Poonia¹,

Kharb

Lather³

et al. 2016

Future Sci. OA

146

View full text Add to dashboard Cite

show abstract

“…92,[99][100][101][102][103][104] Approximately 70% of the bioactive molecules incorporated into the mixture are well encapsulated into the carrier system and effectively reach the target site without much drop in bioactivity. 99,104,105 Solid phase lipids generally used to prepare nanostructured lipid carriers include acetyl alcohol, glycerol monosterate, and stearic acid and the liquid phase lipid includes caprylic …”

Section: 93mentioning

confidence: 99%

“…The liquid lipid concentrations determine the size of the nanolipid particles. 92,104,107 Higher concentrations of the liquid lipid particles make a smaller sized nanolipid particle but a higher release rate of the bioactive particles. 107 Based on the structure of the matrix lipids, nanolipid carrier particles are subdivided into three types, such as the imperfect type, which contains less oil, leading to lower stability of the bioactive molecules.…”

mentioning

confidence: 99%

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Ganesan¹,

Ko²,

Kim³

et al. 2015

IJN

102

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Oxidative stress plays a very critical role in neurodegenerative diseases, such as Parkinson’s disease (PD), which is the second most common neurodegenerative disease among elderly people worldwide. Increasing evidence has suggested that phytobioactive compounds show enhanced benefits in cell and animal models of PD. Curcumin, resveratrol, ginsenosides, quercetin, and catechin are phyto-derived bioactive compounds with important roles in the prevention and treatment of PD. However, in vivo studies suggest that their concentrations are very low to cross blood–brain barrier thereby it limits bioavailability, stability, and dissolution at target sites in the brain. To overcome these problems, nanophytomedicine with the controlled size of 1–100 nm is used to maximize efficiency in the treatment of PD. Nanosizing of phytobioactive compounds enhances the permeability into the brain with maximized efficiency and stability. Several nanodelivery techniques, including solid lipid nanoparticles, nanostructured lipid carriers, nanoliposomes, and nanoniosomes can be used for controlled delivery of nanobioactive compounds to brain. Nanocompounds, such as ginsenosides (19.9 nm) synthesized using a nanoemulsion technique, showed enhanced bioavailability in the rat brain. Here, we discuss the most recent trends and applications in PD, including 1) the role of phytobioactive compounds in reducing oxidative stress and their bioavailability; 2) the role of nanotechnology in reducing oxidative stress during PD; 3) nanodelivery systems; and 4) various nanophytobioactive compounds and their role in PD.

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“…The five model drugs with different solubility, Cypate (poorly soluble), fluorescein (slightly soluble), paclitaxel (slightly soluble), DOX hydrochloride (soluble), and fluorescein sodium (highly soluble), were encapsulated into macrophages to compare the achievable DL and encapsulation efficiencies. N-succinyl-N′-octyl Chitosan (SOC) and nanostructured lipid carriers (NLCs), [20][21][22][23] consisting of polysaccharide and partial crystallized lipid particles are useful delivery systems with high DL efficiency, encapsulation efficiency (EE), and stability. By possessing high cell permeability, these nanoparticles can effectively improve the bioavailability of drugs with poor water solubility.…”

mentioning

confidence: 99%

Nanomedicine engulfed by macrophages for targeted tumor therapy

Li¹,

Feng²,

Ding³

et al. 2016

IJN

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Macrophages, exhibiting high intrinsic accumulation and infiltration into tumor tissues, are a novel drug vehicle for directional drug delivery. However, the low drug-loading (DL) capacity and the drug cytotoxicity to the cell vehicle have limited the application of macrophages in tumor therapy. In this study, different drugs involving small molecular and nanoparticle drugs were loaded into intrinsic macrophages to find a better way to overcome these limitations. Their DL capacity and cytotoxicity to the macrophages were first compared. Furthermore, their phagocytic ratio, dynamic distributions, and tumoricidal effects were also investigated. Results indicated that more lipid-soluble molecules and DL particles can be phagocytized by macrophages than hydrophilic ones. In addition, the N -succinyl- N ′-octyl chitosan (SOC) DL particles showed low cytotoxicity to the macrophage itself, while the dynamic biodistribution of macrophages engulfed with different particles/small molecules showed similar profiles, mainly excreted from liver to intestine pathway. Furthermore, macrophages loaded with SOC–paclitaxel (PTX) particles exhibited greater therapeutic efficacies than those of macrophages directly carrying small molecular drugs such as doxorubicin and PTX. Interestingly, macrophages displayed stronger targeting ability to the tumor site hypersecreting chemokine in immunocompetent mice in comparison to the tumor site secreting low levels of chemokine in immunodeficiency mice. Finally, results demonstrated that macrophages carrying SOC–PTX are a promising pharmaceutical preparation for tumor-targeted therapy.

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Enhancement of gastrointestinal absorption of isoliquiritigenin by nanostructured lipid carrier

Cited by 28 publications

References 50 publications

Nanostructured Lipid Carriers: Versatile Oral Delivery Vehicle

Nanostructured Lipid Carriers: Versatile Oral Delivery Vehicle

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Nanomedicine engulfed by macrophages for targeted tumor therapy

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Enhancement of gastrointestinal absorption of isoliquiritigenin by nanostructured lipid carrier

Cited by 28 publications

References 50 publications

Nanostructured Lipid Carriers: Versatile Oral Delivery Vehicle

Nanostructured Lipid Carriers: Versatile Oral Delivery Vehicle

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson&rsquo;s disease models

Nanomedicine engulfed by macrophages for targeted tumor therapy

Contact Info

Product

Resources

About

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models