Enhancement of gastric mucosal integrity by Lactobacillus rhamnosus GG

Lam, Emily Kai Yee; Tai, Emily Kin Ki; Koo, Marcel W.L.; Wong, Hai Ming; Wu, William Ka Kei; Lin, Yongcheng; So, Wallace H.L.; Woo, Patrick C. Y.; Cho, C.H.

doi:10.1016/j.lfs.2007.03.018

Cited by 94 publications

(79 citation statements)

References 36 publications

(39 reference statements)

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“…Numerous studies have shown that apoptotic cell death of gastric mucosal cells has an important role in GML (18)(19)(20). In line with this, the present study found that the expression of Bax, caspase-3 and caspase-7 was higher in the stomach tissues of HAPC-induced GML patients than that in the healthy controls, suggesting that cell apoptosis also takes an active part in HAPC-induced GML.…”

Section: Discussionsupporting

confidence: 90%

Mechanism of apoptosis involved in gastric mucosal lesions in Tibetans with high-altitude polycythemia

Li¹,

Gesang²,

Cai³

2017

Experimental and Therapeutic Medicine

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Section: Discussionsupporting

confidence: 90%

Mechanism of apoptosis involved in gastric mucosal lesions in Tibetans with high-altitude polycythemia

Li¹,

Gesang²,

Cai³

2017

Experimental and Therapeutic Medicine

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“…Pre-treatment with Lactococcus rhamnosus also significantly increases the basal mucosal prostaglandin E2 (PGE2) level, also attenuates the suppressive actions of ethanol on mucus secreting layer and transmucosal resistance and reduces cellular apoptosis in the gastric mucosa. Hence we can say Lactococcus rhamnosus is an antiulcerative in many ways as reported by researchers (Lam et al, 2007).…”

Section: Lab In Diseases Managementmentioning

confidence: 53%

Overview of Anticancer activity of Lactic Acid bacteria

Delesa¹

2017

Int. J. Adv. Res. Biol. Sci.

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Cancer vestiges one of the leading causes of deaths worldwide despite its advances treatment and detection and the conventional chemotherapeutic agents used for the treatment of cancer have non-specific toxicity toward normal body cells that cause various side effects. In addition, cancer cells are known to develop chemotherapy resistance in due course of treatment, so, it's difficult and not easy to treat cancer using normal antiviral drugs. Thus, the demand for novel anti-cancer agents is increasing important to develop novel biological control approach. Some research reports have shown the therapeutic potential of LAB against various types of cancer cell lines. This makes them promising candidates for further investigation and clinical treatments. While a myriad of healthful effects have been attributed to lactic acid bacteria (LAB), perhaps the most controversial remains that of anticancer activity. The precise mechanisms by which LAB may inhibit any cancer are currently unknown. However, such mechanisms might include: alteration of the metabolic activities of intestinal microflora; alteration of physico-chemical conditions in the colon and gut; binding and degrading potential carcinogens; quantitative and/or qualitative alterations in the intestinal microflora incriminated in producing putative carcinogen(s) and promoters; production of antitumourigenic or antimutagenic compounds; enhancing the host's immune response; and effects on physiology of the host. In this review article, we present the overview of anticancer activity of the lactic acid bacteria.

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“…LGG increases the production of Muc6 and basal mucosal PGE2, resulting in an increased thickness of the mucosal mucus layer of the stomach (Lam et al, 2007). In addition to bacteria, Garcia Vilela et al (2008) reported that yeast Saccharomyces boulardii induces the improvement but not normalization in leaky gut of CD patients.…”

Section: Reinforcement Of Barrier Functionmentioning

confidence: 99%