Enhancement of focused ultrasound with microbubbles on the treatments of anticancer nanodrug in mouse tumors

Lin, Chung-Yin; Li, Jiarong; Tseng, Hsiao-Ching; Wu, Ming‐Fang; Lin, Win-Li

doi:10.1016/j.nano.2011.10.005

Cited by 51 publications

(28 citation statements)

References 24 publications

(28 reference statements)

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“…This effect was demonstrated by Lin et al (31) in a series of studies in tumor-bearing mice. Following the completion of sonication therapy, the authors administered doxorubicin (Dox).…”

mentioning

confidence: 64%

Ultrasound-mediated targeted drug delivery: recent success and remaining challenges

Castle

Butts

Healey

et al. 2013

American Journal of Physiology-Heart and Circulatory Physiology

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contrast-enhanced ultrasound; gene therapy; microbubble drug delivery PRESENTLY, CONTRAST-ENHANCED ultrasound (CEUS) imaging focuses on diagnostic clinical applications. In the future, however, therapeutic uses of CEUS will create a paradigm shift for patient care and the pharmaceutical industry. Ultrasound contrast agents (UCAs) are composed of shelled microbubbles that serve as superior diagnostic agents while traversing the smallest of blood vessels resulting in unparalleled, real-time spatial and temporal imaging of intact tissues and organs. These microscopic, gas-filled microspheres acting as intravascular indicators represent ideal carrier vehicles for local delivery of ultrasound-directed drug and gene therapies. The conceptually simple application of external acoustic energy in the transformation of these inert, microspheres into powerful therapeutic systems has seemingly unlimited potential.Brief history of CEUS. All diagnostic imaging modalities use and require contrast effects to increase signal-to-noise ratios, permitting enhanced discrimination of the targets. Examples include the use of radiopaque contrast agents to create discrete image patterns using X-ray methods (ionizing radiation), thus creating enhanced detection of objects within the image plane. Similar to X-ray, positron emission tomography and radionuclide imaging procedures rely on radioactive emitters to highlight anatomy and provide information on cellular metabolism and physiology.

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“…This effect was demonstrated by Lin et al (31) in a series of studies in tumor-bearing mice. Following the completion of sonication therapy, the authors administered doxorubicin (Dox).…”

mentioning

confidence: 64%

Ultrasound-mediated targeted drug delivery: recent success and remaining challenges

Castle

Butts

Healey

et al. 2013

American Journal of Physiology-Heart and Circulatory Physiology

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“…Zhoa et al 2012 insonated breast cancer cells in the presence of microbubbles and doxorubicin-loaded liposomes; they reported that ultrasound mediated cavitation lead to the observed reduction in cell viability in the treated cell cultures. In an in vivo study, Lin et al (2012[a]) used polyethylene glycol coated liposomes loaded with doxorubicin to treat a murine colorectal adenocarcinoma implanted subcutaneously in mice. Microbubbles were injected intravenously and the tumor was insonated at a higher pressure amplitude of 1.2 MPa, prior to the injection of the chemotherapeutic agent.…”

Section: Ultrasound Mediated Chemotherapymentioning

confidence: 99%

“…Utilizing a low intensity insonation in the presence of microbubbles similar to that used by Wood et al (2007; 2008), Lin et al (2012[a]) found in rabbits that the growth of colorectal adenocarcinoma was inhibited. They hypothesized, however, that during insonation oscillation of the microbubble and its collapse with violent cavitation may disrupt the walls of the tumor neovasculature and so delay tumor growth.…”

Section: Antivascular Ultrasoundmentioning

confidence: 99%

A Review of Low-Intensity Ultrasound for Cancer Therapy

Wood

Sehgal

2015

Ultrasound in Medicine & Biology

281

230

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The literature describing the use of low-intensity ultrasound in four major areas of cancer therapy was reviewed - sonodynamic therapy, ultrasound mediated chemotherapy, ultrasound mediated gene delivery and antivascular ultrasound therapy. Each technique consistently resulted in the death of cancer cells and the bioeffects of ultrasound were primarily attributed to thermal actions and inertial cavitation. In each therapeutic modality, theranostic contrast agents composed of microbubbles played a role in both therapy and vascular imaging. The development of these agents is important as it establishes a therapeutic-diagnostic platform which can monitor the success of anti-cancer therapy. Little attention, however, has been given to either the direct assessment of the underlying mechanisms of the observed bioeffects or to the viability of these therapies in naturally occurring cancers in larger mammals; if such investigations provided encouraging data there could be a prompt application of a therapy technique in treating cancer patients.

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“…Microbubbles can potentially be used as carriers for nanoscale US contrast agents and the incorporation of multimodal probes with potential therapeutic applications: sonodynamic therapy, ultrasound-induced apoptosis, sonoporation/sonotransfection, ultrasound-induced drug/gas delivery, and focused ultrasound-induced thermal ablation [32,33,280,[292][293][294][295][296][297][298][299].…”

Section: Ultrasound (Us)mentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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Enhancement of focused ultrasound with microbubbles on the treatments of anticancer nanodrug in mouse tumors

Cited by 51 publications

References 24 publications

Ultrasound-mediated targeted drug delivery: recent success and remaining challenges

Ultrasound-mediated targeted drug delivery: recent success and remaining challenges

A Review of Low-Intensity Ultrasound for Cancer Therapy

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

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