Enhancement of fluorescence-based sensing using microstructured optical fibres

Afshar, V Shahraam; Warren‐Smith, Stephen C.; Monro, Tanya M.

doi:10.1364/oe.15.017891

Cited by 95 publications

(63 citation statements)

References 36 publications

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“…A full vectorial model to simulate the captured fluorescence was used, based on a model previously presented in [25,30]. This model is based on a step-index glass-ethanol geometry, which is a close approximation to the suspended-core fiber geometry.…”

Section: Suspended Core Fiber Sensorsmentioning

confidence: 99%

Quantification of the fluorescence sensing performance of microstructured optical fibers compared to multi-mode fiber tips

et al. 2016

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Rights url: https://www.osapublishing.org/submit/review/copyright_permissions.cfm# Creative Commons LicensingOSA is aware that some authors, as a condition of their funding, must publish their work under a Creative Commons license. We therefore offer a CC BY license for authors who indicate that their work is funded by agencies that we have confirmed have this requirement. Authors must enter their funder(s) during the manuscript submission process. At that point, if appropriate, the CC BY license option will be available to select for an additional fee.Any subsequent reuse or distribution of content licensed under CC BY must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Abstract: Microstructured optical fibers, particularly those with a suspended-core geometry, have frequently been argued as efficient evanescent-field fluorescence-based sensors. However, to date there has not been a systematic comparison between such fibers and the more common geometry of a multi-mode fiber tip sensor. In this paper we make a direct comparison between these two fiber sensor geometries both theoretically and experimentally.Our results confirm that suspended-core fibers provide a significant advantage in terms of total collected fluorescence signal compared to multi-mode fibers using an equivalent experimental configuration. Noordegraaf, K. Nielsen, A. Carlsen, and A. Bjarklev, "Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions," Opt. Lett. 29(17), 1974-1976 (2004). 12. E. Coscelli, M. Sozzi, F. Poli, D. Passaro, A. Cucinotta, S. Selleri, R. Corradini, and R. Marchelli, "Toward a highly specific DNA biosensor: Pna-modified suspended-core photonic crystal fibers," IEEE J. Sel. Top. Quantum Electron. 16(4), 967-972 (2010). 13. S. C. Warren-Smith, G. Nie, E. P. Schartner, L. A. Salamonsen, and T. M. Monro, "Enzyme activity assays within microstructured optical fibers enabled by automated alignment," Biomed. Opt. Express 3(12), 3304-3313 (2012). Opt. Quantum Electron. 26(3), S261-S272 (1994). 17. C. Bariain, I. R. Matías, F. J. Arregui, and M. Lopez-Amo, "Optical fiber humidity sensor based on a tapered fiber coated with agarose gel," Sensor. Actuat. Biol. Chem. 69, 127-131 (2000). 18. L. C. Shriver-Lake, K. A. Breslin, P. T. Charles, D. W. Conrad, J. P. Golden, and F. S. Ligler, "Detection of tnt in water using an evanescent wave fiber-optic biosensor," Anal. Chem. 67(14), 2431-2435 (1995)

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Section: Suspended Core Fiber Sensorsmentioning

confidence: 99%

Quantification of the fluorescence sensing performance of microstructured optical fibers compared to multi-mode fiber tips

et al. 2016

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“…One important parameter for fiber sensing is the fraction of optical power that propagates externally to the fiber substrate and can thus be used to interact with an analyte. Several types of MOF allow for high power fractions such as band-gap fibers [2,3], liquid-core fibers [4,5], and small-core fibers [6][7][8][9][10][11][12][13][14][15][16][17]. In addition, small-core high-index fibers have been predicted to offer increased sensitivity due to the presence of high intensity evanescent fields adjacent to the core-cladding interface [7].…”

Section: Introductionmentioning

confidence: 99%

“…However, these results did not consider the case of a core pumped fiber and did not include effects due to fiber loss or Beer's law absorption. These factors have subsequently been included for the case of a suspended-core geometry (sometimes described as a wagon wheel or steering wheel), which have similar characteristics to conventional step-index fibers [7][8][9]. It was found that the existence of localized high-intensity electric and magnetic field layers of the fundamental mode at the boundary interface of small-core fibers leads to an increase in fluorescence capture when high index glasses are used.…”

Section: Introductionmentioning

confidence: 99%

“…In this paper the previous theoretical results [7][8][9] are extended to include the capture by higher order modes and to include additional loss mechanisms (confinement loss and smallcore loss), which have not previously been incorporated into the theory. Combining these factors provides a rigorous model of the fluorescence sensing properties of optical nanowires, which we demonstrate is in quantitative agreement with experiment.…”

Section: Introductionmentioning

confidence: 99%

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Fluorescence-based sensing with optical nanowires: a generalized model and experimental validation

Warren‐Smith¹,

Afshar²,

Monro³

2010

Opt. Express

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OSA grants to the Author(s) (or their employers, in the case of works made for hire) the following rights:(b)The right to post and update his or her Work on any internet site (other than the Author(s') personal web home page) provided that the following conditions are met: (i) access to the server does not depend on payment for access, subscription or membership fees; and (ii) any such posting made or updated after acceptance of the Work for publication includes and prominently displays the correct bibliographic data and an OSA copyright notice (e.g. "© 2009 The Optical Society"). Abstract:A model for the fluorescence sensing properties of small-core high-refractive-index fibers (optical nanowires) is developed and compared quantitatively with experiment. For the first time, higher-order modes and loss factors relevant to optical nanowires are included, which allows the model to be compared effectively with experiment via the use of fluorophore filled suspended optical nanowires. Numerical results show that high-index materials are beneficial for fluorescence-based sensing. However, both numerical and experimental results show that the fluorescence signal is relatively insensitive to core size, except for low concentration sensing where nanoscale fiber cores are advantageous due to the increased evanescent field power.

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“…As such the organic sensing molecule needs to be photostable, especially if required over extended periods and repeated use, and particularly if fixed to the photon rich waveguide surface. [20,21] The use of a fluorescent photoswitch in these systems offers some advantage over simply detecting absorbance changes. Fluorescence spectroscopy is more versatile for signal acquisition as the instrumentation for analyte excitation and detection needs only to be on one 'side' of the sample, since the fluorescent signal can travel back along the fibre, which allows a wider range of applications; such as, fibre optic tip based sensing.…”

mentioning

confidence: 99%

A comparative study of the fluorescence and photostability of common photoswitches in microstructured optical fibre

Stubing

Heng

Monro

et al. 2017

Sensors and Actuators B: Chemical

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 If accepted for publication, we encourage authors to link from the preprint to their formal publication via its Digital Object Identifier (DOI). Millions of researchers have access to the formal publications on ScienceDirect, and so links will help your users to find, access, cite, and use the best available version. Authors can update their preprints on arXiv or RePEc with their accepted manuscript. Please note: Cell Press, The Lancet, and some society-owned titles have different preprint policies. Information on these is available on the journal homepage. Preprints should not be added to or enhanced in any way in order to appear more like, or to substitute for, the final versions of articles. December 2016Fluorescence Abstract:The fluorescence spectra and photostability under 532 nm laser excitation of four different common photoswitches (an azobenzene, spiropyran, indolylfulgide, and a diarylperfluorocyclopentene) was investigated in a silica microstructured optical fibre. An example of each photoswitch was examined both in solution as well as physically adsorbed to the silica fibre surface. This comparison was made to determine any fluorescence behavioral differences as a result of each solution and the optical fibre fluorescence sensing platform, and to determine which photoswitch has the best performance in this light intense microenvironment. It was found that the azobenzene and the spiropyran showed the most favorable behavior; showing a stronger fluorescence response and the least degradation of the fluorescence signal.

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Enhancement of fluorescence-based sensing using microstructured optical fibres

Cited by 95 publications

References 36 publications

Quantification of the fluorescence sensing performance of microstructured optical fibers compared to multi-mode fiber tips

Quantification of the fluorescence sensing performance of microstructured optical fibers compared to multi-mode fiber tips

Fluorescence-based sensing with optical nanowires: a generalized model and experimental validation

A comparative study of the fluorescence and photostability of common photoswitches in microstructured optical fibre

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