Enhancement of electro-chemical properties of TiO2 nanotubes for biological interfacing

Khudhair, Dhurgham; Hamedani, Hoda Amani; Gaburro, Julie; Shafei, Sajjad; Nahavandi, Saeid; Garmestani, Hamid; Bhatti, Asim

doi:10.1016/j.msec.2017.03.112

Cited by 22 publications

(14 citation statements)

References 38 publications

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“…6 showed that the nanostructured film (as-prepared and after annealing) was formed by mixtures of oxides of elements that compound the alloy [8,48]. Titanium and niobium oxides show bioactivity in vitro and in vivo tests [61,62], whereas it was demonstrated that amorphous nanotubes are adequate surfaces for cell adhesion [63,64]. Being that the anatase phase may to enhance the growth process of hydroxyapatite [56].…”

Section: Resultsmentioning

confidence: 99%

Characterization of the morphology, structure and wettability of phase dependent lamellar and nanotube oxides on anodized Ti-10Nb alloy

Luz

Santos

Lepienski

et al. 2018

Applied Surface Science

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Nanotubes grown on Ti and its alloys have been extensively investigated for the biomaterials applications, since these structures improve the surface biocompatibility and the corrosion resistance due to oxide formation. Some researchers showed that the microstructure of the pure Ti affect the morphology of nanotubes grown by anodic process. However, this subject is rarely investigated for nanotubes grown on Ti alloys. In the same way, nanostructured films formed by concomitant regions of tubes and lamellar structures hardly ever were reported. Investigations concerning these topics are required once beta titanium alloys are suitable candidates to replace the pure Ti and Ti-Al-V alloys for biomedical applications. Beta alloys composed of non-toxic elements (Nb, Ta, Mo) are biocompatible and have an excellent mechanical properties and corrosion resistance. The present work investigated questions regarding to the effect of microstructure of Ti-10Nb alloy on morphology of nanostructured film growth by anodization. The morphology, thickness, composition and atomic arrangement (amorphous/crystalline) of formed oxides, and the contact angle of anodic film were investigated. The X-ray diffraction patterns and SEM image show that the Ti-10Nb alloy is composed by alpha (hcp) and beta (bcc) phases. SEM and TEM techniques revel that self-organized nanotubes grew on alpha phase, whereas a lamellar structure with transversal holes grew on b-phase. Crystalline oxides are formed at oxide-metal interface, as indicated by X-ray diffraction patterns. However, the tubes and lamellas grown over the compact oxide are amorphous, as-prepared and annealed at 230°C for 3 h, as showed by SAED patterns. The nanostructured films annealed at 430°C and at 530°C were damaged. A few changes were observed in XRD patterns of film annealed at 230°C while the morphology held similar as the unannealed film. Finally, the presence of phosphorus ions incorporated into the anodic layer makes the surface hydrophilic, since a similar nanostructured film without phosphorous incorporation results hydrophobic.

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Section: Resultsmentioning

confidence: 99%

Characterization of the morphology, structure and wettability of phase dependent lamellar and nanotube oxides on anodized Ti-10Nb alloy

Luz

Santos

Lepienski

et al. 2018

Applied Surface Science

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“…27 As previous studies have reported, anodic oxidation is a controlled and cost-effective technology to form TiO 2 nanoscale structures with tunable morphology that is achieved by adjusting voltage and electrolyte concentrations relating to the procedure. 28,29 Figure 1B shows the SEM images of two layers of the cellular TiO 2 nanotube array. From the superior aspect, the sample was divided into a large amount of homogeneous hexagonal nanoscale cells that each had a diameter of approximately 160 nm, and there were approximately 50 nanopores with a diameter approximately 15 nm in each hexagonal cell.…”

Section: Resultsmentioning

confidence: 99%

Decreased <em>Porphyromonas gingivalis</em> adhesion and improved biocompatibility on tetracycline-loaded TiO<sub>2</sub> nanotubes: an in vitro study

Sun¹,

Xu²,

Sun³

et al. 2018

IJN

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BackgroundTitanium dioxide (TiO2) nanotubes are often used as carriers for loading materials such as drugs, proteins, and growth factors.Materials and methodsIn this study, we loaded tetracycline onto TiO2 nanotubes to demonstrate its antibacterial properties and biocompatibility. The two-layered anodic TiO2 nanotubes with a honeycomb-like porous structure were fabricated by using a two-step anodization, and they were loaded with tetracycline by using a simplified lyophilization method and vacuum drying. Their physical properties, such as chemical compositions, wettability, and surface morphologies of the different samples, were observed and measured by X-ray photoelectron spectroscopy (XPS), contact angle measurement, and scanning electron microscopy (SEM). The in vitro growth behaviors of mouse bone marrow stromal cells (BMSCs) on these substrates were investigated.ResultsThe TiO2 nanotube (NT) substrates and the tetracycline-loaded TiO2 nanotube (NT-T) substrates revealed a crucial potential for promoting the adhesion, proliferation, and differentiation of BMSCs. Similarly, the NT-T substrates displayed a sudden release of tetracycline in the first 15 minutes of their administration, and the release tended to be stable 90 minutes later. The antibacterial performances of the prepared substrates were assessed with Porphyromonas gingivalis. The result showed that NT and NT-T substrates had antibacterial capacities.ConclusionOverall, this research provides a promising method with potential for clinical translation by allowing local slow release of antimicrobial compounds by loading them onto constructed nanotubes.

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“…Among different materials of similar morphology, nanotubes of a narrow range of materials limited to iridium oxide and carbon have been employed for the application of neural interfacing [10,12,2]. High electrochemical impedance, toxicity and fabrication complexity are the main limitations of metal oxide nanotubes hindering their use in neural interface application [13]. Vertically oriented TiO2 nanotube arrays have been widely studied as a promising biocompatible material for a broad range of biomedical applications [14,15,16].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Copper, Zinc and Strontium Doping on Electrochemical Properties of Titanium Dioxide Nanotubes for In Vitro Neural Recording

Khudhair¹,

Gaburro²,

Hamedani³

et al. 2021

Preprint

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Direct interaction with the neuronal cells is a prerequisite to deciphering useful information in understanding the underlying causes of diseases and functional abnormalities in the brain. Precisely fabricated nanoelectrodes provide the capability to interact with the brain in its natural habitat without compromising its functional integrity. Considerable research has been focused on the employment of vertical nanotubes as nanoelectrodes due to large-scale intracellular recording capability and longer-term intracellular access that arise from their unique geometry. Despite many types of nanotube structures reported in the literature, a limited subset of the nanotubes has been investigated for neural interfacing. This work reports on the fabrication and optimisation of vertically oriented titania nanotube arrays as a scalable electrode platform for neural interface application. To this end, the doping was performed by incorporating a selected group of biologically active metallic ions, including zinc, strontium, and copper, into TiO2 lattice and its effect was studied with respect to the structural, electrochemical and biological properties of the nanotube arrays. It was found that doping can change the length, diameter and wall thickness of the nanotubes. Among pure and doped samples, the copper-doped TiO2 nanotubes demonstrated the highest electrochemical and biological performance. Our results suggest that the doping can be used as a promising method to optimise the properties of nanotube arrays for the development of high-performance neural electrodes.

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Enhancement of electro-chemical properties of TiO2 nanotubes for biological interfacing

Cited by 22 publications

References 38 publications

Characterization of the morphology, structure and wettability of phase dependent lamellar and nanotube oxides on anodized Ti-10Nb alloy

Characterization of the morphology, structure and wettability of phase dependent lamellar and nanotube oxides on anodized Ti-10Nb alloy

Decreased <em>Porphyromonas gingivalis</em> adhesion and improved biocompatibility on tetracycline-loaded TiO<sub>2</sub> nanotubes: an in vitro study

Investigation of Copper, Zinc and Strontium Doping on Electrochemical Properties of Titanium Dioxide Nanotubes for In Vitro Neural Recording

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Enhancement of electro-chemical properties of TiO2 nanotubes for biological interfacing

Cited by 22 publications

References 38 publications

Characterization of the morphology, structure and wettability of phase dependent lamellar and nanotube oxides on anodized Ti-10Nb alloy

Characterization of the morphology, structure and wettability of phase dependent lamellar and nanotube oxides on anodized Ti-10Nb alloy

Decreased <em>Porphyromonas gingivalis</em> adhesion and improved biocompatibility on tetracycline-loaded TiO<sub>2</sub>&nbsp;nanotubes: an in vitro study

Investigation of Copper, Zinc and Strontium Doping on Electrochemical Properties of Titanium Dioxide Nanotubes for In Vitro Neural Recording

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Decreased <em>Porphyromonas gingivalis</em> adhesion and improved biocompatibility on tetracycline-loaded TiO<sub>2</sub> nanotubes: an in vitro study