Enhancement of DNA damage repair potential in germ cells of Caenorhabditis elegans by a volatile signal from their irradiated partners

Tang, Honggang; Chen, Liangwen; Dai, Zhangyu; Zhang, Wenjing; Wang, Ting; Wu, Lijun; Wang, Gaohong; Bian, Po

doi:10.1016/j.dnarep.2019.102755

Cited by 5 publications

(11 citation statements)

References 48 publications

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“…Recently our group has demonstrated the production of radiation-induced volatile signal depends on ascarosides secreted by C. elegans 31 . In this study, we found that the production of volatile signals induced by heat stress is not related to ascarosides (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…1A. Our group has recently demonstrated that C. elegans irradiated with gamma-irradiation at 25Gy released volatile stress signal to induce radio-adaptive responses (RAR) in naive (unirradiated) C. elegans 31 . We then hypothesized that the heat-stress-induced volatile signal might induce RAR in the top worms.…”

Section: Heat-stress-induced Production Of the Volatile Stress Signal...mentioning

confidence: 99%

“…The plates with worms were transferred to the incubator at 20 °C immediately following heat stress treatment until the plates were returned to 20 ℃ . The heat stressed worms were placed at the bottom of the co-culture system, and other operating methods were described in Tang et al 31 , as shown in Fig. 7.…”

Section: Protocols For Co-culture Of Wormsmentioning

confidence: 99%

“…Recently our group has demonstrated that C. elegans at 25Gy irradiated with gamma-irradiation released volatile stress signal to induce radio-adaptive responses (RAR) in naive (unirradiated) C. elegans 31 . However, so far there have been few reports about volatile signal between C. elegans under natural stress.…”

Section: Introductionmentioning

confidence: 99%

“…However, so far there have been few reports about volatile signal between C. elegans under natural stress. In order to determine whether C. elegans produce and response to such a type of volatile stress signal, we used previous co-cultivation system 31 , in which radio-adaptive responses (RAR) of embryonic lethality was used as a physiological/developmental endpoint to evaluate the presence of volatile stress signal.…”

Section: Introductionmentioning

confidence: 99%

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Evidence of communication between heat-stressed and unheat-stressed Caenorhabditis elegans via volatile stress signal

chen

Wang

Zhou

et al. 2022

Preprint

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Our research group has recently described that radiation-induced airborne stress signals can be communicated between Caenorhabditis elegans (C. elegans). This paper addresses the question of whether heat stress can also induce emission of airborne stress signal to alert neighboring C. elegans and elicit their subsequent stress response. Here, we report that heat-stressed C. elegans produces volatile stress signal(s) that trigger an increase in radiation resistance in neighboring unheat-stressed C. elegans. When several loss-of-function mutations affecting the thermosensory neuron (AFD), heat shock factor-1 (HSF-1), and small heat-shock proteins (HSPs) were used as the heat-stressed C. elegans, we found that the production of the volatile stress signal(s) were blocked, demonstrating the heat shock response as a role in controlling the production of the volatile stress signal(s). It can be found that the mutations affecting DNA damage response (DDR) could inhibit the increasing of radiation resistance in neighboring unheat-stressed C. elegans having received the volatile stress signal(s), which indicate that the DDR might contribute to RAR induction by the volatile stress signal(s). Together, this study demonstrates that heat-stressed nematodes could communicate with unheat-stressed nematodes via volatile stress signal. In addition, the regulating pattern of signal production and action are preliminarily clarified.

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Section: Discussionmentioning

confidence: 99%

Section: Heat-stress-induced Production Of the Volatile Stress Signal...mentioning

confidence: 99%

Section: Protocols For Co-culture Of Wormsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evidence of communication between heat-stressed and unheat-stressed Caenorhabditis elegans via volatile stress signal

chen

Wang

Zhou

et al. 2022

Preprint

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Radiation and chemical induced genomic instability as a driver for environmental evolution

Mothersill

Rusin

Elliott³

et al. 2021

Genome Stability

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Investigation into the communication between unheated and heat-stressed Caenorhabditis elegans via volatile stress signals

Chen

Wang

Zhou

et al. 2023

Sci Rep

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Our research group has recently found that radiation-induced airborne stress signals can be used for communication among Caenorhabditis elegans (C. elegans). This paper addresses the question of whether heat stress can also induce the emission of airborne stress signals to alert neighboring C. elegans and elicit their subsequent stress response. Here, we report that heat-stressed C. elegans produces volatile stress signals that trigger an increase in radiation resistance in neighboring unheated C. elegans. When several loss-of-function mutations affecting thermosensory neuron (AFD), heat shock factor-1, HSP-4, and small heat-shock proteins were used to test heat-stressed C. elegans, we found that the production of volatile stress signals was blocked, demonstrating that the heat shock response and ER pathway are involved in controlling the production of volatile stress signals. Our data further indicated that mutations affecting the DNA damage response (DDR) also inhibited the increase in radiation resistance in neighboring unheated C. elegans that might have received volatile stress signals, indicating that the DDR might contribute to radioadaptive responses induction by volatile stress signals. In addition, the regulatory pattern of signal production and action was preliminarily clarified. Together, the results of this study demonstrated that heat-stressed nematodes communicate with unheated nematodes via volatile stress signals.

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Enhancement of DNA damage repair potential in germ cells of Caenorhabditis elegans by a volatile signal from their irradiated partners

Cited by 5 publications

References 48 publications

Evidence of communication between heat-stressed and unheat-stressed Caenorhabditis elegans via volatile stress signal

Evidence of communication between heat-stressed and unheat-stressed Caenorhabditis elegans via volatile stress signal

Radiation and chemical induced genomic instability as a driver for environmental evolution

Investigation into the communication between unheated and heat-stressed Caenorhabditis elegans via volatile stress signals

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