Enhancement of complement-dependent cytotoxicity by linking factor-H derived SCRs 19-20 to CD20 antibodies
Heribert Stoiber,
Lena Prantl,
Philipp Heider
et al.
Abstract:Antibody-mediated complement-dependent cytotoxicity (CDC) on malignant cells is regulated by several complement regulating proteins (CRP), including the inhibitory complement factor H (fH). FH consists of 20 short consensus repeat elements (SCRs) with specific functional domains. Previous research revealed that the fH-derived SCRs 19–20 (SCR1920) can displace full-length fH on the surface of chronic lymphocytic leukemia (CLL) cells, which sensitizes CLL cells for e.g. CD20-targeting therapeutic monoclonal anti… Show more
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