Abstract:Background: Clavulanic acid (CA) is a potent β-lactamase inhibitor used to combat resistance to penicillin and cephalosporin antibiotics. There are several pathogenic microorganisms that are capable of secreting β-Lactamases. These enzymes catalyze the hydrolysis of the β-lactam ring of penicillins and cephalosporins, and their hydrolysis products have no antibiotic activity. Since the first clinical applications, the efficiency of the β-lactam antibiotics has been declining, due to the astonishing increasing … Show more
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