Enhancement of Central Noradrenaline Release during Development Alters the Packing Density of Neurons in the Rat Occipital Cortex

Ruíz, Samuel; Fernández, Vı́ctor; Belmar, Jorge; Hernández, Alejandro; Pérez, Hernán; Sanhueza-Tsutsumi, Miguel; Alarcón, Sandy Escobar; Soto-Moyano, Rubén

doi:10.1159/000244405

Cited by 5 publications

(1 citation statement)

References 23 publications

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“…The morphogenetic changes that are observed most consistently with neonatal NE depletions are reductions in dendritic branching and spine densities, as well as overall reductions in brain size (Brenner et al, 1985;Felten et al, 1982;Kolb & Sutherland, 1992;Loeb et al, 1987;Onteniente et al, 1980;Osterheld-Haas & Homung, 1996). On the other hand, enhancement of central noradrenergic transmission neonatally appears to increase the cortical neuropil (Ruiz et al, 1997).…”

Section: Introductionmentioning

confidence: 98%

Neonatal 5,7‐DHT Lesions Cause Sex‐Specific Changes in Mouse Cortical Morphogenesis

et al. 2000

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Both monoaminergic and cholinergic afferent projections to the neocortex putatively modulate cortical morphogenesis and plasticity. Previously we showed that neonatal,electrolytic lesions: the cholinergic nucleus basalis magnocel!ularis (nBM) projections to the neocortex result in significant decreases-of cortical layer width that correlate with cognitive alterations. Such electrolytic lesions, performed for lack of a selective neurotoxin in mice, may affect mono- aminergic fibers of passage. Here, we investigate the effects of neonatal 5,7 dihydroxytryptamine (5,7-DHT) focal injections into the nBM region on cortical laminar morphology in adult male and female mice. 5,7-DHT lesions on the first postnatal day resulted in significant cortical depletion of both serotonin and norepinephrine that attenuated with age. Generally, cortical layer widths increased in response to the lesion; the effects were layer, region, and sex specific. Previous reports from our laboratories described longterm behavioral alterations after comparable focal, neonatal 5,7-DHT lesions. The studies described here provide an anatomical basis for such behavioral alterations. Our data suggest that monoaminergic and cholinergic projections to the cortex may have opposite effects on the developing cortical neuropil. Jointly, our morphological and behavioral findings may have important implications for a variety of developmental disorders in humans and provide some insights into sex differences in the penetrance of these disorders.

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