2012
DOI: 10.1371/journal.pone.0035199
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Enhancement of Cell-Based Therapeutic Angiogenesis Using a Novel Type of Injectable Scaffolds of Hydroxyapatite-Polymer Nanocomposite Microspheres

Abstract: BackgroundClinical trials demonstrate the effectiveness of cell-based therapeutic angiogenesis in patients with severe ischemic diseases; however, their success remains limited. Maintaining transplanted cells in place are expected to augment the cell-based therapeutic angiogenesis. We have reported that nano-hydroxyapatite (HAp) coating on medical devices shows marked cell adhesiveness. Using this nanotechnology, HAp-coated poly(l-lactic acid) (PLLA) microspheres, named nano-scaffold (NS), were generated as a … Show more

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Cited by 62 publications
(54 citation statements)
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References 51 publications
(86 reference statements)
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“…In particular, previous studies revealed the efficacy of cell therapy for CLI is dosage dependent, which usually required at least 1 × 10 6 ∼ 1 × 10 7 cells to exert significant therapeutic functions, and 1 × 10 5 cells could not effectively induce therapeutic angiogenesis in mouse models (11,20). To improve the efficacy of cell therapy for CLI, we developed a cell delivery strategy based on primed 3D injectable microniches to achieve superior therapeutic effects for CLI with cell dosage (1 × 10 5 cells) 10 times less than the lowest dosage (1 × 10 6 cells) used in all previously reported CLI therapy.…”
Section: Discussionmentioning
confidence: 99%
“…In particular, previous studies revealed the efficacy of cell therapy for CLI is dosage dependent, which usually required at least 1 × 10 6 ∼ 1 × 10 7 cells to exert significant therapeutic functions, and 1 × 10 5 cells could not effectively induce therapeutic angiogenesis in mouse models (11,20). To improve the efficacy of cell therapy for CLI, we developed a cell delivery strategy based on primed 3D injectable microniches to achieve superior therapeutic effects for CLI with cell dosage (1 × 10 5 cells) 10 times less than the lowest dosage (1 × 10 6 cells) used in all previously reported CLI therapy.…”
Section: Discussionmentioning
confidence: 99%
“…The HAp-nanoparticle-coated microspheres showed improved cell adhesion and spreading compared with bare biodegradable microspheres [285]. Recently, Mima et al [368] showed the effectiveness of HAp-coated biodegradable polymer microspheres as an injectable cell scaffold for cell-based therapeutic angiogenesis. a challenging task.…”
Section: Nanoparticle Coating Via Pickering Emulsion Routementioning
confidence: 99%
“…Moreover, MP possess many features that make them suitable for use as cardiac scaffolds. In particular, they are biodegradable, biocompatible, non-toxic and, importantly, they can provide structural support for cell survival and differentiation [18][19][20][21][22][23][24].…”
Section: Introductionmentioning
confidence: 99%