1997
DOI: 10.1093/jac/40.3.345
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Enhancement of Burkholderia cepacia antimicrobial susceptibility by cationic compounds

Abstract: Infections in cystic fibrosis (CF) due to Burkholderia cepacia are challenging due to their resistance to antibiotics. We explored a new strategy for increasing the permeability of B. cepacia using cationic agents, including amino compounds, to reduce the MICs of standard antibiotics. Twenty-eight B. cepacia isolates from four CF centres in North America and four non-CF B. cepacia were examined by standard microtitre broth dilution methods for susceptibility to a variety of antibiotics in the presence of non-i… Show more

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Cited by 20 publications
(13 citation statements)
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“…2 Pulmonary colonization with B. cepacia in CF patients is associated with high morbidity and mortality, 3,4 as this complex is inherently resistant to several antimicrobial agents, including aminoglycosides. 5 Liposomes are spherical phospholipid bilayers that can be loaded with mediators such as vaccines and antibiotics for safe delivery to the action site. For instance, antifungal antibiotics are able to overcome fungus resistance when they are carried by liposomes.…”
Section: Introductionmentioning
confidence: 99%
“…2 Pulmonary colonization with B. cepacia in CF patients is associated with high morbidity and mortality, 3,4 as this complex is inherently resistant to several antimicrobial agents, including aminoglycosides. 5 Liposomes are spherical phospholipid bilayers that can be loaded with mediators such as vaccines and antibiotics for safe delivery to the action site. For instance, antifungal antibiotics are able to overcome fungus resistance when they are carried by liposomes.…”
Section: Introductionmentioning
confidence: 99%
“…Although cationic peptides and antibiotics appear to be unable to kill Bcc organisms, they may enhance the antimicrobial activity of other antibiotics (37,38), providing physicians with a broader spectrum of therapeutic options for Bcc infections.…”
mentioning
confidence: 99%
“…In particular, clinical isolates of P. aeruginosa and strains of E. coli, S. Typhimurium, and the Gram-positive Staphylococcus aureus are sensitized to some antibiotics by spermine (23). Enhancement of antimicrobial susceptibility by chemical cationic compounds was reported for strains of B. cepacia while spermidine and cadaverine had no effect (spermine was not tested) (36). We have tested the effects of spermine on the growth and antibiotic sensitivity of J2315.…”
Section: Resultsmentioning
confidence: 99%