Enhancement of antimicrobial properties by metals doping in nano-crystalline hydroxyapatite for efficient biomedical applications

Habib, Md. Lawshan; Disha, Sanjana Afrin; Sahadat Hossain, Md.; Uddin, Md. Najem; Ahmed, Samina

doi:10.1016/j.heliyon.2023.e23845

Cited by 4 publications

(1 citation statement)

References 51 publications

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“…Since Sm 3+ has a smaller ionic radius, replacing Ca 2+ ions with Sm 3+ ions showed a preference for Ca1 sites. This fact is proven by the values of the lattice parameters and is in agreement with previous studies [ 53 ]. The lattice parameters, the volume of the unit cell, and the average crystallite size are presented in Table 1 .…”

Section: Resultssupporting

confidence: 93%

Biocompatibility and Osteogenic Activity of Samarium-Doped Hydroxyapatite—Biomimetic Nanoceramics for Bone Regeneration Applications

Balas,

Badea,

Ciobanu

et al. 2024

Biomimetics

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In this study, we report on the development of hydroxyapatite (HAp) and samarium-doped hydroxyapatite (SmHAp) nanoparticles using a cost-effective method and their biological effects on a bone-derived cell line MC3T3-E1. The physicochemical and biological features of HAp and SmHAp nanoparticles are explored. The X-ray diffraction (XRD) studies revealed that no additional peaks were observed after the integration of samarium (Sm) ions into the HAp structure. Valuable information regarding the molecular structure and morphological features of nanoparticles were obtained by using Fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS). The elemental composition obtained by using energy-dispersive X-ray spectroscopy (EDS) confirmed the presence of the HAp constituent elements, Ca, O, and P, as well as the presence and uniform distribution of Sm3+ ions. Both HAp and SmHAp nanoparticles demonstrated biocompatibility at concentrations below 25 μg/mL and 50 μg/mL, respectively, for up to 72 h of exposure. Cell membrane integrity was preserved following treatment with concentrations up to 100 μg/mL HAp and 400 μg/mL SmHAp, confirming the role of Sm3+ ions in enhancing the cytocompatibility of HAp. Furthermore, our findings reveal a positive, albeit limited, effect of SmHAp nanoparticles on the actin dynamics, osteogenesis, and cell migration compared to HAp nanoparticles. Importantly, the biological results highlight the potential role of Sm3+ ions in maintaining cellular balance by mitigating disruptions in Ca2+ homeostasis induced by HAp nanoparticles. Therefore, our study represents a significant contribution to the safety assessment of both HAp and SmHAp nanoparticles for biomedical applications focused on bone regeneration.

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Section: Resultssupporting

confidence: 93%

Biocompatibility and Osteogenic Activity of Samarium-Doped Hydroxyapatite—Biomimetic Nanoceramics for Bone Regeneration Applications

Balas,

Badea,

Ciobanu

et al. 2024

Biomimetics

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Thermal spray processes influencing surface chemistry and in-vitro hemocompatibility of hydroxyapatite-based orthopedic implants

Shankar,

Jayaganesh,

Gowda

et al. 2024

Biomaterials Advances

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Investigation of the effects of glycerol addition as a catalyst on the morphology and structural properties of Gd/Er co-doped hydroxyapatite

Mohammed,

Ateş,

Mahmood

et al. 2024

Journal of Physical Chemistry and Functional Materials

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This study investigates the effects of increasing amounts of glycerol, ranging from 0 to 16 mL, used in the synthesis on the structural properties of Gd and Er-based hydroxyapatite (HAp). The samples were prepared via a wet chemical route, and their characterizations were carried out using X-ray diffraction (XRD), Fourier transform infrared (FTIR), scanning electron microscopy (SEM), and energy dispersive X-ray (EDX) spectroscopy. The XRD and FTIR results confirmed the formation of the HAp phase in the samples. It was observed that the addition of glycerol at different amounts in the synthesis affected the crystallinity degree and crystallite size. The morphology was almost not affected by the glycerol content as used.

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Enhancement of antimicrobial properties by metals doping in nano-crystalline hydroxyapatite for efficient biomedical applications

Cited by 4 publications

References 51 publications

Biocompatibility and Osteogenic Activity of Samarium-Doped Hydroxyapatite—Biomimetic Nanoceramics for Bone Regeneration Applications

Biocompatibility and Osteogenic Activity of Samarium-Doped Hydroxyapatite—Biomimetic Nanoceramics for Bone Regeneration Applications

Thermal spray processes influencing surface chemistry and in-vitro hemocompatibility of hydroxyapatite-based orthopedic implants

Investigation of the effects of glycerol addition as a catalyst on the morphology and structural properties of Gd/Er co-doped hydroxyapatite

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