Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life

Ramírez-Santana, Carolina; Castellote, Cristina; Castell, Margarida; Moltó-Puigmartí, Carolina; Rivero, Montserrat; Pérez-Cano, Francisco J.; Franch, Àngels

doi:10.1016/j.jnutbio.2010.04.005

Cited by 13 publications

(14 citation statements)

References 49 publications

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“…Yamasaki et al (2003) found that the t10, c12 isomer is responsible for CLA effect on immunoglobulin production. In pigs CLA supplementation had little effect on their immune function and blood chemistry variables (Wiegand et al 2011). Ramirez-Santana et al (2011 observed enhancement of antibody synthesis and lowering the proliferative ability of splenocytes in rats by feeding cis-9, trans-11 CLA during early life.…”

Section: Cla and Immune Responsementioning

confidence: 98%

Biological effects of conjugated linoleic acids supplementation

Oleszczuk¹,

Oleszczuk²,

Siwicki³

et al. 2012

Polish Journal of Veterinary Sciences

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Conjugated linoleic acids (CLA) are a group of polyunsaturated fatty acids (PUFA) with a single pair of conjugated double bonds. The major natural CLA isomer is 18:2 cis-9, trans-11 (c9, t11) linoleic acid, or rumenic acid (RA). Chemically synthesized CLA is also available, mostly as a mixture of RA and 18:2 trans-10, cis-12 (t10, c12) isomers in equal amounts (50:50). Consumption of ruminant meat (beef and lamb) and dairy products (milk and cheese) is the main source of dietary exposure to CLA. Despite numerous studies on animal and human models (tumorigenesis, obesity, immune response) it has not been established whether additional supplementation of CLA is of benefit. Moreover, some studies, conducted both in animals and in humans, reveal that CLA isomers may induce insulin resistance. Presently, balanced diet rich in CLA from natural sources is recommended. The purpose of this review was to sum up the results available in the literature.

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Section: Cla and Immune Responsementioning

confidence: 98%

Biological effects of conjugated linoleic acids supplementation

Oleszczuk¹,

Oleszczuk²,

Siwicki³

et al. 2012

Polish Journal of Veterinary Sciences

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“…In this case, nutritional intervention in dams determines the experimental group. When the targeted interventional period for the immunonutrition study is the suckling period, the diet can start just after the delivery up to weaning [77–79]. In this case, it is possible to randomize animals into different experimental groups on the basis of pup criteria (i.e., birth body weight).…”

Section: Suckling Rat As a Model For Immunonutrition Studiesmentioning

confidence: 99%

“…For example, when the test nutrient is labile, it is crucial to protect the pelleted diet from light, temperature, humidity, oxygen by an appropriate packaging and changing the diet in the cage every day. It is important to bear in mind that suckling rats usually start eating the dam's pelleted diet around the second week of life (days 12–14), and therefore the intake of the test nutrient can be increased [10, 11, 79]. …”

Section: Suckling Rat As a Model For Immunonutrition Studiesmentioning

confidence: 99%

“…The delivery can be natural or induced. In this regard, some authors allow the rats to deliver at term [77, 79] and some others induce it by subcutaneous injection of oxytocin (1 IU per animal) on the 21st day of their pregnancy [85]. Variables such as litter size should be recorded in order to discard differences among groups before dietary intervention or to evidence the effects of a nutritional intervention during gestation.…”

Section: Suckling Rat As a Model For Immunonutrition Studiesmentioning

confidence: 99%

“…But sometimes a useful approach is to adjust the amount of tested nutrient as an extrapolation of the consumption from an adult diet in which the proportion of the nutrient is known in the pelleted diet (i.e., 1% w/w). In order to calculate the equivalent volume of the solution to administer to neonates, data from the daily intake of rats from 21 to 28 days old (10–15 g chow/100 g of rat body weight) can be used [79]. …”

Section: Suckling Rat As a Model For Immunonutrition Studiesmentioning

confidence: 99%

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The Suckling Rat as a Model for Immunonutrition Studies in Early Life

Pérez-Cano

Franch

Castellote

et al. 2012

Clinical and Developmental Immunology

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Diet plays a crucial role in maintaining optimal immune function. Research demonstrates the immunomodulatory properties and mechanisms of particular nutrients; however, these aspects are studied less in early life, when diet may exert an important role in the immune development of the neonate. Besides the limited data from epidemiological and human interventional trials in early life, animal models hold the key to increase the current knowledge about this interaction in this particular period. This paper reports the potential of the suckling rat as a model for immunonutrition studies in early life. In particular, it describes the main changes in the systemic and mucosal immune system development during rat suckling and allows some of these elements to be established as target biomarkers for studying the influence of particular nutrients. Different approaches to evaluate these immune effects, including the manipulation of the maternal diet during gestation and/or lactation or feeding the nutrient directly to the pups, are also described in detail. In summary, this paper provides investigators with useful tools for better designing experimental approaches focused on nutrition in early life for programming and immune development by using the suckling rat as a model.

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Butter, Ghee, and Cream Products

Kwak

Ganesan

2013

Milk and Dairy Products in Human Nutrition

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Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life

Cited by 13 publications

References 49 publications

Biological effects of conjugated linoleic acids supplementation

Biological effects of conjugated linoleic acids supplementation

The Suckling Rat as a Model for Immunonutrition Studies in Early Life

Butter, Ghee, and Cream Products

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