Enhancement of antibiotic activity by phytocompounds of Turnera subulata

Abstract

Several studies have shown that plants of plant origin are more relevant, where the antibacterial and modulating action of antibiotic resistance is highlighted. Turnera subulata is popularly known as "chanana". This plant species is commonly used in Brazilian popular medicine to treat infections and In the search for new alternatives to treat infections caused by resistant microorganisms, many studies. The present study aimed to evaluate the antibacterial and modulating activity of the methyl extract obtained from Turnera subulate alone or in combination with aminoglycoside antibiotics, using the microdilution method. The methyl extract of Turnera subulata was used alone in the antibacterial test, and in combination with antibiotics in the modulation assay. All tests were performed in triplicate. The methyl extract of Turnera subulata presented both antibacterial and antibiotic-modulating effects in vitro, alone or in association with aminoglycosides. The activity of the extract depends on the bacterial strain and may be associated with the presence of tannins and flavonols. However, further studies are required to characterize the potential of Turnera subulata in the development of new drugs against multiresistant bacteria.

Chemical Characterization of Flowers and Leaf Extracts Obtained from Turnera subulata and Their Immunomodulatory Effect on LPS-Activated RAW 264.7 Macrophages

“…Thus, this study presented the chemical profile characterization of aqueous and hydroethanolic extracts of T. subulata flower and leaf by mass spectrometry, as well as the evaluation of their anti-inflammatory properties in an in vitro model. At this point, it is noteworthy that only a few studies have reported the presence of phenolic compounds especially in T. subulata flowers, as well as their pharmacological properties [ 25 , 26 , 35 ].…”

Chemical Profile and Biological Activities of Essential Oil from Piper arboreum for Development and Improvement of Mouthwash

“…In this way, the oil showed significant results when combined with other substances but did not show relevant results when tested in isolation. This may have occurred because the oil is a complex mixture of several compounds in variable amounts, allowing the oil to act on different targets [ 51 ].…”