Enhancement of antibacterial properties and biocompatibility of Ti6Al4V by graphene oxide/strontium nanocomposite electrodepositing

Wang, Xing; Diwu, Weilong; Guo, Jianbin; Yan, M.; Ma, Wei; Yang, Min; Bi, Long; Han, Yisheng

doi:10.1016/j.bbrc.2023.05.002

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…The results showed a decreased corrosion rate and improved cell viability, in vitro, for samples with a 0.5 and a 1.0 wt.% of rGO-HA. The authors of [16] showed an increase in the antibacterial properties of Ti6Al4V alloys with the electrodeposition of the composite coating of graphene oxide (GO) and strontium (Sr) on its surface. In [17], the graphene oxide/carbon fiber/polyetheretherketone (GO/CF/PEEK) composite coatings obtained by electrostatic powder deposition on Ti6Al4V alloys demonstrated a decrease in the friction coefficient (the COF) (from 0.433 to 0.008), increased wear resistance, and good cytocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Tribological Characteristics of PEO Coatings Formed on Ti6Al4V Titanium Alloy in Electrolytes with Graphene Oxide Additives

et al. 2023

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Coatings with a thickness from ~40 to ~50 µm on Ti6Al4V titanium alloys were formed by plasma electrolytic oxidation (PEO) in a silicate-hypophosphite electrolyte with the addition of graphene oxide. The PEO treatment was carried out in the anode–cathode mode (50 Hz) at a ratio of anode and cathode currents of 1:1; their sum density was 20 A/dm2, and the treatment’s duration was 30 min. The effect of the graphene oxide’s concentration in the electrolyte on the thickness, roughness, hardness, surface morphology, structure, composition, and tribological characteristics of the PEO coatings was studied. Wear experiments, under dry conditions, were carried out in a ball-on-disk tribotester with an applied load of 5 N, a sliding speed of 0.1 m·s−1, and a sliding distance of 1000 m. According to the obtained results, the addition of graphene oxide (GO) into the base silicate-hypophosphite electrolyte leads to a slight decrease in the coefficient of friction (from 0.73 to 0.69) and a reduction in the wear rate by more than 1.5 times (from 8.04 to 5.2 mm3/N·m), with an increase in the GO’s concentration from 0 to 0.5 kg/m3, respectively. This occurs due to the formation of a GO-containing lubricating tribolayer upon contact with the coating of the counter-body in the friction pair. Delamination of the coatings during wear occurs due to contact fatigue; with an increase in the concentration of GO in the electrolyte from 0 to 0.5 kg/m3, this process slows down by more than four times.

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Section: Introductionmentioning

confidence: 99%

Investigation of Tribological Characteristics of PEO Coatings Formed on Ti6Al4V Titanium Alloy in Electrolytes with Graphene Oxide Additives

et al. 2023

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Inhibitory Effect of Heparin/Polyarginine/Hyaluronic Acid Complex on Coronary Artery Restenosis by Loading Vascular Endothelial Growth Factor

Zeng,

Wang,

Yang

et al. 2023

sci adv mater

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This research was aimed to investigate the inhibitory effect of heparin/polyarginine/hyaluronic acid (HPHA) complex loaded with vascular endothelial growth factor (VEGF) on coronary artery restenosis (CAR). Dopamine was grafted to obtain dopamine-hyaluronic acid (DPA) composite material, and heparin/polyarginine (HP) nanoparticles (NPs) loaded with VEGF were obtained through electrostatic binding (ESB). The HP NPs loaded with VEGF mixed with hyaluronic acid (HA) were mixed in a 10:1 volume ratio to obtain a composite solution, namely HPHA complex. Next, the sodium metaperiodate was added to form a hydrogel. The samples were characterized using a zeta potential (ZP) analyzer, transmission electron microscopy (TEM), Fourier transform infrared spectrometer (FTIR), and water contact angle (WCA). Enzyme-linked immunosorbent assay (ELISA) and toluidine blue O (TBO) staining were employed to assess the immobilization and release of VEGF and heparin. Rhodamine staining was adopted to evaluate the adhesion of platelets, fibrinogen, macrophages, and umbilical artery smooth muscle cells (UASMCs). Furthermore, CCK-8 assay was performed to evaluate the adhesion and proliferation of endothelial cells (ECs). The results revealed that compared to 0 mg/L, the particle size (PS), polydispersity index (PDI), and θ angle decreased, and the absolute value of ZP increased at 100, 200, 300, and 400 mg/L. The cumulative release (CR) of VEGF at 200 mg/L was higher to that at 0 mg/L, while that of heparin was lower (P <0.05). The platelet surface coverage rate (PSCR), relative platelet activation rate (RPAR), and fibrinogen coverage rate (FCR) at 10 and 20 days were lower and exhibited great difference to those at 0 mg/L (P <0.05). Compared to groups II and III, group I presented a markedly higher number of macrophages and UASMCs on the first and third days of culture (P <0.05). 3 days after culture, adhesion and proliferation of ECs in groups U, I, and K increased greatly (P <0.05). In conclusion, the HPHA complex prepared from HP NPs loaded with VEGF and HA in this research exhibited good stability, uniformity, hydrophilicity, and blood compatibility. It effectively blocked the adhesion of macrophages and UASMCs and promoted the proliferation of ECs, thus conforming to the mechanism of inhibiting CAR after coronary stent intervention.

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Enhancement of antibacterial properties and biocompatibility of Ti6Al4V by graphene oxide/strontium nanocomposite electrodepositing

Cited by 2 publications

References 33 publications

Investigation of Tribological Characteristics of PEO Coatings Formed on Ti6Al4V Titanium Alloy in Electrolytes with Graphene Oxide Additives

Investigation of Tribological Characteristics of PEO Coatings Formed on Ti6Al4V Titanium Alloy in Electrolytes with Graphene Oxide Additives

Inhibitory Effect of Heparin/Polyarginine/Hyaluronic Acid Complex on Coronary Artery Restenosis by Loading Vascular Endothelial Growth Factor

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