Enhancement of anti-tumor activity of gamma-irradiated silk fibroin via immunomodulatory effects

Byun, Eui Baek; Sung, Nak Yun; Kim, Jae‐Hun; Choi, Jong Il; Matsui, Toshiro; Byun, Myung Woo; Lee, Ju Woon

doi:10.1016/j.cbi.2010.03.032

Cited by 36 publications

(25 citation statements)

References 22 publications

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“…These results suggest that PTA administration could activate these immune cells, allowing them to exert immunomodulatory effects in H22 tumor-bearing mice. Cytokines including IL-2, IL-6, IFN-γ and TNF-α have been shown to play a prominent role in the modulation of modulating anti-tumor immune responses that abrogate tumor growth, and have been extensively tested pre-clinically in vitro and in vivo, as well as among patients in the clinic for immunotherapy of malignant diseases [37][38][39][40]. The cytokines IL-2 and IL-6 are capable of inducing the proliferation of responsive T-cells.…”

Section: Discussionmentioning

confidence: 99%

Anti-Tumor Effects of the Polysaccharide Isolated from Tarphochlamys Affinis in H22 Tumor-Bearing Mice

Tang

Huang

Xiong

et al. 2016

Cell Physiol Biochem

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Background: The previous studies have demonstrated that the polysaccharide isolated from Tarphochlamys affinis (PTA) exhibits anti-tumor effect on S₁₈₀ tumor-bearing mice and protective effects against hepatic injury. Methods: In this study, we investigated the anti-tumor activity and possible underlying mechanism of PTA on liver cancer using a murine H22 hepatocarcinoma model. Results: PTA was capable of repressing transplanted H22 solid hepatic tumor cell growth in vivo. The relative weight of immune organs (spleen and thymus) and lymphocyte proliferation induced by ConA or LPS were improved after PTA treatment. Furthermore, treatment with PTA promoted immune-stimulating serum cytokine secretion in H22 tumor-bearing mice. Additionally, the percentage of CD4⁺ T lymphocytes, CD8⁺ T lymphocytes and NK cells was increased in tumor-bearing mice following PTA administration. In tumor tissue, PTA significantly up-regulated the expression of Bax and p53 proteins and down-regulated the expression of Bcl-2 protein. In addition, at the therapeutic dose, PTA displayed very few toxic effects to major organs, such as the liver and kidney, in tumor-bearing mice. Conclusion: In H22 tumor-bearing mice, PTA exhibited prominent anti-tumor activity in vivo. The possible mechanism of action might be related to enhanced host immune system function and induction of H22 tumor cell apoptosis.

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Section: Discussionmentioning

confidence: 99%

Anti-Tumor Effects of the Polysaccharide Isolated from Tarphochlamys Affinis in H22 Tumor-Bearing Mice

Tang

Huang

Xiong

et al. 2016

Cell Physiol Biochem

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“…Polysaccharides are considered to be a consequence of stimulation of the immune response in the host [31][32][33]. IL-2, IL-6, IL-12 and TNF-␣ play a prominent role in both immunoregulation and antitumor mechanisms, and have been extensively tested in vitro and in vivo, as well as in clinical practice for the immunotherapy of malignant diseases [34,35]. In the present study, the effect of IP3a on production of serum IL-2, IL-6, IL-12 and TNF-␣ in jurkat-bearing mice was investigated by using ELISA kits.…”

Section: Effect Of Ip3a On Serum Cytokine Production Inmentioning

confidence: 99%

Purification, characterization and biological activity of a novel polysaccharide from Inonotus obliquus

Chen

Huang

Cui

et al. 2015

International Journal of Biological Macromolecules

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“…Solid: Resistance to / toxicitiy as a result of γ- radiation need to be explored before final sterilization of a dried SF / protein drug blend can be used [207]…”

Section: Figurementioning

confidence: 99%

Silk constructs for delivery of musculoskeletal therapeutics

Meinel¹,

Kaplan²

2012

Advanced Drug Delivery Reviews

100

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Silk fibroin (SF) is a biopolymer with distinguishing features from many other bio- as well as synthetic polymers. From a biomechanical and drug delivery perspective, SF combines remarkable versatility for scaffolding (solid implants, hydrogels, threads, solutions), with advanced mechanical properties and good stabilization and controlled delivery of entrapped protein and small molecule drugs, respectively. It is this combination of mechanical and pharmaceutical features which render SF so exciting for biomedical applications. his pattern along with the versatility of this biopolymer have been translated into progress for musculoskeletal applications. We review the use and potential of silk fibroin for systemic and localized delivery of therapeutics in diseases affecting the musculoskeletal system. We also present future directions for this biopolymer as well as the necessary research and development steps for their achievement.

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Enhancement of anti-tumor activity of gamma-irradiated silk fibroin via immunomodulatory effects

Cited by 36 publications

References 22 publications

Anti-Tumor Effects of the Polysaccharide Isolated from Tarphochlamys Affinis in H22 Tumor-Bearing Mice

Anti-Tumor Effects of the Polysaccharide Isolated from Tarphochlamys Affinis in H22 Tumor-Bearing Mice

Purification, characterization and biological activity of a novel polysaccharide from Inonotus obliquus

Silk constructs for delivery of musculoskeletal therapeutics

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