Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system☆☆☆★★★

Nel, André E.; Díaz-Sánchez, David; Ng, David; Hiura, Timothy S.; Saxon, Andrew

doi:10.1016/s0091-6749(98)70269-6

Cited by 383 publications

(327 citation statements)

References 99 publications

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“…Studies using fractionated organic DEP extract have demonstrated that quinones and PAHs are representative organic chemical groups that could contribute to the oxidant injury in the lung [23][24][25]. PAHs can be converted to quinones via biotransformation, e.g.…”

Section: Generation Of Oxidative Stress By Ambient Particulate Pollutmentioning

confidence: 99%

“…These acute exacerbations are characterized by increased symptom score as well as the requirement for more frequent medication and hospitalization [39,40]. In addition to these acute effects, which are likely caused by an exacerbation of already existing airway inflammation and airway hyperreactivity, there is increasing evidence that particulate pollutants act as an adjuvant for allergic sensitization to common environmental allergens [25,[42][43][44][45][46]. This raises the possibility that long-term PM exposures may lead to increased prevalence of asthma and allergic diseases.…”

Section: The Impact Of Particulate Pollutants On Asthmamentioning

confidence: 99%

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The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

Xia

Nel

2008

Free Radical Biology and Medicine

802

529

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Ambient particulate matter (PM) is an environmental factor that has been associated with increased respiratory morbidity and mortality. The major effect of ambient PM on the pulmonary system is the exacerbation of inflammation, especially in susceptible people. One of the mechanisms by which ambient PM exerts its proinflammatory effects is the generation of oxidative stress by its chemical compounds and metals. Cellular responses to PM-induced oxidative stress include activation of antioxidant defense, inflammation, and toxicity. The pro-inflammatory effect of PM in the lung is characterized by increased cytokine/chemokine production and adhesion molecule expression. Moreover, there is evidence that ambient PM can act as an adjuvant for allergic sensitization, which raises the possibility that long-term PM exposure may lead to increased prevalence of asthma. In addition to ambient PM, rapid expansion of nanotechnology has introduced the potential that engineered NP may also become airborne and may contribute to pulmonary diseases by novel mechanisms that could include oxidant injury. Currently, little is known about the potential adverse health effect of these particles. In this communication, the mechanisms by which particulate pollutants, including ambient PM and engineered NP, exert their adverse effects through the generation of oxidative stress and the impacts of oxidant injury in the respiratory tract will be reviewed. The importance of cellular antioxidant and detoxification pathways in protecting against particle-induced lung damage will also be discussed.

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Section: Generation Of Oxidative Stress By Ambient Particulate Pollutmentioning

confidence: 99%

Section: The Impact Of Particulate Pollutants On Asthmamentioning

confidence: 99%

The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

Xia

Nel

2008

Free Radical Biology and Medicine

802

529

View full text Add to dashboard Cite

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“…Several toxicological and epidemiological studies have confirmed the relationship of exposure of particles to human health (Brunekreef et al, 1997;Dockery et al, 1993;Saxon and Diaz-Sanchez, 2000;Schwartz et al, 1996). There are several studies that have also indicated the cofounding effects of anthropogenic aerosols (such as industrial emissions, traffic exhausts) and naturally occurring bioaerosols in respiratory disorders (Nel et al, 1998;Takenaka et al, 1995). Emissions from traffic-related sources in urban areas have been examined by several researchers (Cadle et al, 1999;Gillies and Gertler, 2000;HEI, 2002;Schauer et al,1996;Shi et al, 1999).…”

Section: Introductionmentioning

confidence: 98%

UNMIX modeling of ambient PM2.5 near an interstate highway in Cincinnati, OH, USA

McDonald

Martuzevičius

et al. 2006

Atmospheric Environment

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The "Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS)" is underway to determine if infants who are exposed to diesel engine exhaust particles are at an increased risk for atopy and atopic respiratory disorders, and to determine if this effect is magnified in a genetically at risk population. In support of this study, a methodology has been developed to allocate local traffic source contributions to ambient PM 2.5 in the Cincinnati airshed. As a first step towards this allocation, UNMIX was used to generate factors for ambient PM 2.5 at two sites near at interstate highway. Procedures adopted to collect, analyze and prepare the data sets to run UNMIX are described. The factors attributed to traffic sources were similar for the two sites. These factors were also similar to locally measured truck engine-exhaust enriched ambient profiles. The temporal variation of the factors was analyzed with clear differences observed between factors attributed to traffic sources and combustion-related regional secondary sources.

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“…Thus, we evaluate microenvironmental exposures to both PM 2.5 and ultrafines. In addition, we measure particle -bound polycyclic aromatic hydrocarbons (PAHs ), which are considered to be potential carcinogens /mutagens ( US DHHS, 1995 ) and have been shown to affect the immune system ( Nel et al, 1998 ) and lead to intrauterine growth retardation ( Dejmek et al, 2000 ), among other outcomes. For these pollutants, the primary goals of our analysis are to:…”

Section: Introductionmentioning

confidence: 99%

Particulate matter and polycyclic aromatic hydrocarbon concentrations in indoor and outdoor microenvironments in Boston, Massachusetts

Levy

Dumyahn

Spengler

2002

J Expo Sci Environ Epidemiol

114

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Estimating personal exposures to air pollution is a crucial component in identifying high -risk populations and determining efficient control strategies. Because of the difficulty of comprehensively measuring personal exposure, data on air pollution patterns in homogenous microenvironments linked with activity data are often used as surrogates. In this study, we focus on strengthening the available information about nonresidential microenvironmental exposures to particulate matter and other combustion pollutants. During the summer of 2000, we measured ultrafine particles, fine particulate matter ( PM 2.5 ), and particlebound polycyclic aromatic hydrocarbons ( PAHs ) outdoors and in indoor microenvironments in Boston, Massachusetts. In indoor microenvironments averaged across sample days, mean ultrafine particle concentrations ranged from 3800 to 140,000 particles / cm 3 , with 7 -200 g / m 3 of PM 2.5 and 5 -12 ng / m 3 of particle -bound PAH. PM 2.5 indoor -outdoor ratios generally exceeded 1 in settings with high levels of human activity, with lower ratios for ultrafine particles. Cooking activities contributed significantly to elevated levels of all three pollutants. Using Linear Mixed Effects models with AR -1 autoregressive correlation structures, 10 -min average outdoor concentrations were generally weak predictors of indoor levels, with stronger relationships in an apartment without mechanical ventilation than in air -conditioned nonresidential settings. Although further study would be needed to determine whether these patterns could be generalized beyond the monitored sites, these data support previous findings and enhance our knowledge about nonresidential exposure patterns.

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Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system☆☆☆★★★

Cited by 383 publications

References 99 publications

The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

UNMIX modeling of ambient PM2.5 near an interstate highway in Cincinnati, OH, USA

Particulate matter and polycyclic aromatic hydrocarbon concentrations in indoor and outdoor microenvironments in Boston, Massachusetts

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