Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin

Liu, Y.; Sun, Yunong; Zhao, Xiaoyan; Kim, Ji Young; Luo, Lu; Wang, Qian; Meng, Xiangmin; Li, Yonghui; Song, Nan; Chen, Zhou Feng; Pan, C.; Li, Liang; Zhang, Yan

doi:10.1007/s12264-019-00373-w

Cited by 13 publications

(12 citation statements)

References 86 publications

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“…In the CNS, 5-HT functions to inhibit aggression, thereby controlling domestic behaviors [161][162][163]. The 5-HT deficiency theory of aggression is driven from the negative correlation between the changes of the CNS 5-HT and aggressiveness in humans [164,165], non-human primates [166], rodents [25,167], and chickens [24,168]. Aggressive animals have low levels of 5-HT in the brain, including in the hypothalamus [169][170][171].…”

Section: Serotonin and Aggressionmentioning

confidence: 99%

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Gut-Brain Axis: Probiotic,Bacillus subtilis, Prevents Aggression via the Modification of the Central Serotonergic System

Cheng¹,

Jiang²,

Hu³

2019

Oral Health by Using Probiotic Products

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Intestinal bacteria release various neuroactive compounds directly or indirectly regulating brain function to modulate host health and behavior through the gut-brain axis. Probiotics have been used as dietary supplements to target gut microbiota (microbiome) for prevention or therapeutic treatment of various diseases including mental disorders. In our study, chickens were used as an animal model to assess, if dietary supplementation of probiotic, Bacillus subtilis, reduces aggressive behaviors following social challenge. Chickens of an aggressive line were housed in single-hen cages. At 24 weeks of age, the hens were paired with similar body weight to identify the dominance rank (day 0). The subordinate and dominant of each pair were fed a regular layer diet or the diet mixed with 250 ppm probiotics for 2 weeks, then the second behavior test was performed between the same pair (day 14). The display of aggressive behaviors in the regular diet-fed chickens was not affected between the levels at day 0 and day 14, while the frequency of threat and aggressive pecking were reduced in the probiotic-fed chickens compared to the levels at day 0. These results suggest dietary probiotic, Bacillus subtilis, could be a suitable strategy for increasing hosts' mental health.

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Section: Serotonin and Aggressionmentioning

confidence: 99%

“…The brain serotonergic system plays a critical role in regulating behaviors, especially aggression [21,22]. Concentrations of 5-HT and its metabolites, as well as the density of 5-HT receptors, have been used as major indicators of aggressive behaviors in humans and experimental animals [23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Gut-Brain Axis: Probiotic,Bacillus subtilis, Prevents Aggression via the Modification of the Central Serotonergic System

Cheng¹,

Jiang²,

Hu³

2019

Oral Health by Using Probiotic Products

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“…Only limited behaviors such as flight, freezing, and rearing can be identified based on changes in the patterns of the cross-sectional area and position [ 31 ]. In addition, the AIBM system is not suitable for multiple-animal paradigms, such as aggression tests [ 32 , 33 ]. This is because it is not possible to resolve the trajectories of multiple animals in close proximity since the information recorded by the infrared detector is insufficient to distinguish between animals.…”

Section: Discussionmentioning

confidence: 99%

An Infrared Touch System for Automatic Behavior Monitoring

et al. 2021

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Key requirements of successful animal behavior research in the laboratory are robustness, objectivity, and high throughput, which apply to both the recording and analysis of behavior. Many automatic methods of monitoring animal behavior meet these requirements. However, they usually depend on high-performing hardware and sophisticated software, which may be expensive. Here, we describe an automatic infrared behavior-monitor (AIBM) system based on an infrared touchscreen frame. Using this, animal positions can be recorded and used for further behavioral analysis by any PC supporting touch events. This system detects animal behavior in real time and gives closed-loop feedback using relatively low computing resources and simple algorithms. The AIBM system automatically records and analyzes multiple types of animal behavior in a highly efficient, unbiased, and low-cost manner.

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“…Although it is just a primary marker, and its expression alone is not sufficient to assess neuronal activation in some specific brain regions [6], compared to other IEGs such as Arc, c-jun, and AP-1, the expression of cFos is easy to detect and has many advantages in identifying activated or inactivated neurons. Moreover, the induction threshold of c-fos appears to be rather high [7][8][9][10][11]. Thus, cFos mapping has become a widely applied marker for the activation of neural systems and for determining the neuronal circuits underlying stimulus-elicited behaviors.…”

Section: Introductionmentioning

confidence: 99%

cFos-ANAB: A cFos-based Web Tool for Exploring Activated Neurons and Associated Behaviors

et al. 2021

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cFos is one of the most widely-studied genes in the field of neuroscience. Currently, there is no systematic database focusing on cFos in neuroscience. We developed a curated database-cFos-ANAB-a cFos-based web tool for exploring activated neurons and associated behaviors in rats and mice, comprising 398 brain nuclei and sub-nuclei, and five associated behaviors: pain, fear, feeding, aggression, and sexual behavior. Direct relationships among behaviors and nuclei (even cell types) under specific stimulating conditions were constructed based on cFos expression profiles extracted from original publications. Moreover, overlapping nuclei and sub-nuclei with potentially complex functions among different associated behaviors were emphasized, leading to results serving as important clues to the development of valid hypotheses for exploring as yet unknown circuits. Using the analysis function of cFos-ANAB, multi-layered pictures of networks and their relationships can quickly be explored depending on users' purposes. These features provide a useful tool and good reference for early exploration in neuroscience. The cFos-ANAB database is available at www.cfos-db.net.

show abstract

Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin

Cited by 13 publications

References 86 publications

Gut-Brain Axis: Probiotic,Bacillus subtilis, Prevents Aggression via the Modification of the Central Serotonergic System

Gut-Brain Axis: Probiotic,Bacillus subtilis, Prevents Aggression via the Modification of the Central Serotonergic System

An Infrared Touch System for Automatic Behavior Monitoring

cFos-ANAB: A cFos-based Web Tool for Exploring Activated Neurons and Associated Behaviors

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