Enhancement of absorption and hepatoprotective potential through soya-phosphatidylcholine-andrographolide vesicular system

Jain, Pushpendra Kumar; Khurana, Navneet; Pounikar, Yogesh; Gajbhiye, Asmita; Kharya, Murli Dhar

doi:10.3109/08982104.2012.753456

Cited by 25 publications

(12 citation statements)

References 19 publications

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“…The equimolar dose of drug shows lesser absorption and elevated levels of SGOT and SGPT in serum as compared to its phytosome dose indicating its hepatoprotective nature. 21…”

Section: Hepato-protectivementioning

confidence: 99%

A Review on Therapeutic Applications of Phytosomes

Chivte¹,

Pardhi²,

Joshi³

et al. 2017

J. Drug Delivery Ther.

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Ethnobotanical plants have been used in the treatment of various diseases since antiquity. The phytoconstituents have pharmacological activities such as anti-tumor, anti-inflammatory, antinociceptive, anti-obesity, thermoregulatory effects, cardioprotective, anti-asthmatic, anti-diabetic, anti-oxidant, hepatoprotective and potent CNS activities. Various drug delivery systems like liposomes, niosomes, transferosomes, ethosomes, phytosomes, colloidosomes etc. are developed in order to carry the drug to the site of action without its metabolism. The major concern with respect to phytoconstituents having different chemical nature is its bioavailability and effective dosage concentration which could be overcome by means of phytosome technology. Chemically, phytosomes are vesicles of phospholipids bonded with a hydrogen bond to phytochemical/s. The current review highlights the major therapeutic applications of phytosomes till date. The review discusses about a latest and novel drug delivery system viz. "Phytosome technology" whereby major emphasis has been provided on the different therapeutic applications of phytosomes and its crucial role in managing the conventional complications that are encountered for the delivery of phytoconstituents. Applications of phytosomes such as enhancing bioavailability, anti-cancer and anti-oxidant agent, transdermal delivery, wound healing capacity etc. have been discussed. The comparison between the therapeutic activities of free drug and its phytosomes indicates that the complex provides various advantages over the conventional treatments.

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“…The equimolar dose of drug shows lesser absorption and elevated levels of SGOT and SGPT in serum as compared to its phytosome dose indicating its hepatoprotective nature. 21…”

Section: Hepato-protectivementioning

confidence: 99%

A Review on Therapeutic Applications of Phytosomes

Chivte¹,

Pardhi²,

Joshi³

et al. 2017

J. Drug Delivery Ther.

View full text Add to dashboard Cite

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“…Poor solubility in aqueous media (3.29 ± 0.73 µg/ml) and high lipophilicity (log p value = 2.632 ± 0.135) are the main reasons attributing to the lower bioavailability of AP (3). Several strategies such as preparation of liposome (4), phytovesicles (5), complexation with cyclodextrins (6), solid dispersion with PVP K-30 (7), and nanoparticles (8) were attempted to improve the aqueous solubility and low bioavailability of AP. However, the formulation that explicates the problem of gastric instability, i.e., in the pH range of 1.2 to 7.5 with strategic release has not been reported yet.…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide Encrusted Multilayered Nano-Colloidal System of Andrographolide for Improved Hepatoprotection

et al. 2016

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Andrographolide (AP), a phytoconstituent of Andrographis paniculata is reported as a potent hepatoprotective agent. However, utility of this molecule is restricted due to its low aqueous solubility, gastric instability and hence low bioavailability. It was aimed to formulate and characterize AP-loaded, natural biopolymer stabilized, multilayered nano-hydrocolloid delivery system. Nanoemulsion (NE) was formulated using layer-by-layer (LbL) technology via electrostatic deposition of chitosan over alginate encrusted o/w NE by ultra-sonication. Improved transparency and stability of NE were observed with increasing sonication time. Best stability was obtained after 20 min sonication and particle size of the multilayered NE was measured in the range of 90.8-167.8 nm. Transmission electron microscopy confirmed the progressive layering of nanosized NE. Higher magnitude of zeta potential (i.e., 22.9 to 31.01 mV) confirmed higher stability and coating of alginate layer over NE surface for the period of 3 months. NE showed strategic release pattern when assessed in vitro in various simulated biological fluids of GIT in timed pattern. Multilayered NE showed significant modulation in liver function test (ALT, ALP, AST, TBIL, DBIL, and liver glycogen) and serum cytokines (TNF-α, IL-6, IL-10, and IL-β) when assessed in vivo in galactosamine-lipopolysaccharide intoxicated mice. In conclusion, the andrographolide engrained multi-layered NE enhanced the solubility, stability and henceforth assured the increased availability in simulated biological fluids. The in vivo study exhibited the significantly improved hepatoprotection by andrographolide when delivered in stable multi-layered NE carrier systems.

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“…While in vitro screening shows promise of antiviral activity against CHIKV, its in vivo efficacy needs to be established. Since, oral andrographolide suffers from limitations, including inadequate stability in gastrointestinal tract coupled with poor absorption and rapid clearance, further optimization is required to demonstrate efficacy in pre-clinical models [ 134 ].…”

Section: Inhibitors Of Viral Genome Replicationmentioning

confidence: 99%

Current Strategies for Inhibition of Chikungunya Infection

Subudhi

Chattopadhyay

Mishra

et al. 2018

Viruses

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Increasing incidences of Chikungunya virus (CHIKV) infection and co-infections with Dengue/Zika virus have highlighted the urgency for CHIKV management. Failure in developing effective vaccines or specific antivirals has fuelled further research. This review discusses updated strategies of CHIKV inhibition and provides possible future directions. In addition, it analyzes advances in CHIKV lifecycle, drug-target development, and potential hits obtained by in silico and experimental methods. Molecules identified with anti-CHIKV properties using traditional/rational drug design and their potential to succeed in subsequent stages of drug development have also been discussed. Possibilities of repurposing existing drugs based on their in vitro findings have also been elucidated. Probable modes of interference of these compounds at various stages of infection, including entry and replication, have been highlighted. The use of host factors as targets to identify antivirals against CHIKV has been addressed. While most of the earlier antivirals were effective in the early phases of the CHIKV life cycle, this review is also focused on drug candidates that are effective at multiple stages of its life cycle. Since most of these antivirals require validation in preclinical and clinical models, the challenges regarding this have been discussed and will provide critical information for further research.

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Enhancement of absorption and hepatoprotective potential through soya-phosphatidylcholine-andrographolide vesicular system

Cited by 25 publications

References 19 publications

A Review on Therapeutic Applications of Phytosomes

A Review on Therapeutic Applications of Phytosomes

Polysaccharide Encrusted Multilayered Nano-Colloidal System of Andrographolide for Improved Hepatoprotection

Current Strategies for Inhibition of Chikungunya Infection

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