Enhancement of a Nociceptive Reaction by Opioid Antagonists in Mice

Jacob, J.; Ramabadran, K.

doi:10.1111/j.1476-5381.1978.tb08645.x

Cited by 116 publications

(36 citation statements)

References 37 publications

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“…The hot plate test described by Jacob and Ramabadran (1978) was used. The animals were placed on an aluminum plate that was adapted to a water bath at 50 ± 0.5°C.…”

Section: Hot Plate Testmentioning

confidence: 99%

α-Terpineol reduces nociceptive behavior in mice

Quintans‐Júnior

Oliveira

Santana

et al. 2011

Pharmaceutical Biology

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“…The hot plate test described by Jacob and Ramabadran (1978) was used. The animals were placed on an aluminum plate that was adapted to a water bath at 50 ± 0.5°C.…”

Section: Hot Plate Testmentioning

confidence: 99%

α-Terpineol reduces nociceptive behavior in mice

Quintans‐Júnior

Oliveira

Santana

et al. 2011

Pharmaceutical Biology

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“…In the hot plate test [26] mice were placed on a metal surface kept at 50 Ϯ 1°C. The time(s) between placement and licking of both anterior feet was recorded as response latency.…”

Section: The Hot Plate Testmentioning

confidence: 99%

Antinociceptive effect of the calcium-binding protein MRP-14 and the role played by neutrophils on the control of inflammatory pain

Giorgi

Pagano

Dias

et al. 1998

Journal of Leukocyte Biology

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Macrophages secrete a variety of chemical mediators that play a central role in the pathophysiology of inflammatory pain. Therefore, the activation or deactivation of these cells in an inflammatory focus could modulate the intensity of the algogenic response. Based on these premises and on our previous demonstration that the calciumbinding protein MRP-14, highly expressed in neutrophils, deactivates activated macrophages in vitro, we decided to investigate the role of MRP-14 and of neutrophils in the control of inflammatory pain in mice. Our results show that this protein is endowed with antinociceptive activity. When tested in the writhing model it was able to inhibit pain response but did not change the behavior of the animals in the hot plate test. This observation indicates that MRP-14 down-regulates inflammatory but not central pain. Using a model of acute neutrophilic peritonitis induced by glycogen, a close correlation between neutrophil migration and antinociception was detected. Surgical adrenalectomy demonstrated that the antinociceptive response induced by glycogen was not due to endogenous liberation of glucocorticoids. The treatment of animals either with a monoclonal antibody anti-MRP-14 or a monoclonal antibody that depletes the animals of neutrophils reverts the antinociceptive response observed in the glycogen-induced peritonitis. These data define the calcium-binding protein MRP-14 as a novel mediator for the control of inflammatory pain and consequently discloses an anti-inflammatory role for the neutrophil. J. Leukoc. Biol. 64: 214-220; 1998.

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“…At 300 mg/kg EOCn was also effective during the first phase of the formalin test, an event attributed to a peripheral neural mechanism (16), which suggests the participation of this third mechanism in the antinociception induced by this higher dose of the essential oil. If there is central mechanism participation, it is not likely to involve opiate receptors, since naloxone (11), which blocked the effect of morphine, did not alter EOCn-induced antinociception.…”

mentioning

confidence: 99%

“…The hot-plate test was performed by the method of Jacob et al (11). Briefly, a mouse was placed on a plate maintained at 50.0 ± 1ºC and the latency of its reaction to this nociceptive stimulus (number of seconds before it licked its hind paw or jumped) was quantified, with an interruption time £45 s. Only mice which in a pretest showed a hotplate reaction time £20 s were used in this test.…”

mentioning

confidence: 99%

Antinociceptive effects of the essential oil of Croton nepetaefolius on mice

Abdon

Leal-Cardoso

Coelho‐de‐Souza

et al. 2002

Braz J Med Biol Res

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Croton nepetaefolius Baill. is an aromatic plant native to the northeast of Brazil where it is extensively used in folk medicine as a sedative, orexigen and antispasmodic agent. In the present study the antinociceptive effects of the essential oil of C. nepetaefolius (EOCn), administered orally, were evaluated in male Swiss mice (20-25 g). In the acetic acid-induced writhing test, EOCn (100 and 300 mg/kg; N = 14 and N = 12, respectively) was effective at the highest dose. In the hotplate test, EOCn at 30 and 300 mg/kg, but not at 3 mg/kg, significantly increased the latency at all observation times up to the 180th min (N = 12 for each dose). In the formalin test, EOCn significantly reduced paw licking in the second phase of the test at 100 mg/kg (N = 12), but decreased it in both phases at 300 mg/kg (N = 12). At 30 mg/kg, the effect of EOCn did not differ from control values in either phase of the formalin test (N = 6). Pretreatment with naloxone (5 mg/kg, ip) significantly reversed the analgesic effect of morphine (5 mg/kg, sc) on both phases, but not that of EOCn at 300 mg/kg (N = 6) on both phases of the formalin test. The data show that orally administered EOCn promotes a dose-dependent antinociceptive effect whose mechanisms remain to be elucidated.

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Enhancement of a Nociceptive Reaction by Opioid Antagonists in Mice

Cited by 116 publications

References 37 publications

α-Terpineol reduces nociceptive behavior in mice

α-Terpineol reduces nociceptive behavior in mice

Antinociceptive effect of the calcium-binding protein MRP-14 and the role played by neutrophils on the control of inflammatory pain

Antinociceptive effects of the essential oil of Croton nepetaefolius on mice

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