Enhancement efficiency delivery of antiviral Molnupiravir-drug via the loading with self-assembly nanoparticles of pycnogenol and cellulose which are decorated by zinc oxide nanoparticles for COVID-19 therapy

El-Shafai, Nagi M.; Mostafa, Yasser S.; Ramadan, Mohamed S.; M. El-Mehasseb, Ibrahim

doi:10.1016/j.bioorg.2023.107028

Bioorganic Chemistry

2024

DOI: 10.1016/j.bioorg.2023.107028

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Enhancement efficiency delivery of antiviral Molnupiravir-drug via the loading with self-assembly nanoparticles of pycnogenol and cellulose which are decorated by zinc oxide nanoparticles for COVID-19 therapy

Nagi M. El-Shafai,

Yasser S. Mostafa,

Mohamed S. Ramadan

et al.

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2024

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Cited by 5 publications

References 78 publications

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Bio-study: Modeling of natural nanomolecules as a nanocarrier surface for antioxidant and glucose biosensor

Zanata,

El-Shafai,

Beltagi

et al. 2024

International Journal of Biological Macromolecules

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Bio-study: Modeling of natural nanomolecules as a nanocarrier surface for antioxidant and glucose biosensor

Zanata,

El-Shafai,

Beltagi

et al. 2024

International Journal of Biological Macromolecules

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Removal of pollutants through photocatalysis, adsorption, and electrochemical sensing by a unique plasmonic structure of palladium and strontium oxide nanoparticles sandwiched between 2D nanolayers

El-Gohary,

El-Shafai,

El-Mehasseb

et al. 2024

Journal of Environmental Management

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Solid–Liquid Equilibrium of Molnupiravir in 15 Monosolvents: An Experimental and Molecular Simulation Study

Xu,

Wang,

Zhao

et al. 2024

J. Chem. Eng. Data

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Molnupiravir (MPV) has a strong antiviral effect. However, there are few existing reports on the solubility properties of this drug. In this article, the solubility of MPV in 15 monosolvents was measured using the gravimetric method. Among all experimental solvents, the solubility of MPV was found to be the highest in cyclohexanone and the lowest in ethyl formate. In alcohol solvents, the maximum solubility was observed in s-butanol, while the minimum value was observed in i-butanol. The solubility of MPV increases with an increase in the temperature. Thermodynamic models including the modified Apelblat model, λh model, Yaws model and Abolghasem Jouyban model were chosen to fit the solubility data in 15 monosolvents. The Abolghasem Jouyban model fitted the experimental data best among all the selected models in 15 monosolvents, with relative average deviation (RAD) = 0.0024. Finally, a molecular dynamics simulation, radial distribution function (RDF) analysis, and density functional theory (DFT) calculation were performed. The results indicated that MPV could interact with organic solvents via van der Waals interactions, electrostatic interactions, and hydrogen bonding. The experimental data for MPV will provide significant guidance for the optimization of the crystallization process.

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Enhancement efficiency delivery of antiviral Molnupiravir-drug via the loading with self-assembly nanoparticles of pycnogenol and cellulose which are decorated by zinc oxide nanoparticles for COVID-19 therapy

Cited by 5 publications

References 78 publications

Bio-study: Modeling of natural nanomolecules as a nanocarrier surface for antioxidant and glucose biosensor

Bio-study: Modeling of natural nanomolecules as a nanocarrier surface for antioxidant and glucose biosensor

Removal of pollutants through photocatalysis, adsorption, and electrochemical sensing by a unique plasmonic structure of palladium and strontium oxide nanoparticles sandwiched between 2D nanolayers

Solid–Liquid Equilibrium of Molnupiravir in 15 Monosolvents: An Experimental and Molecular Simulation Study

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