Enhancement by Morphine of Radiographic Contrast Media-Induced Histamine Release in Rat Peritoneal Mast Cells.

Sueyasu, Masanori; Komasu, Chiharu; Hara, Tomoko; Futagami, Koujiro; Kataoka, Yasufumi; Oishi, Ryozo

doi:10.1254/jjp.74.217

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Peritoneal fluids containing mast cells were collected, as described previously (Sueyasu et al ., 1997). Briefly, 20 ml of Hank's balanced salt solution (HBSS m M : NaCl 137, KCl 5.36, MgSO 4 0.2, Na 2 HPO 4 0.34, KH 2 PO 4 0.44, NaHCO 3 4.17, CaCl 2 1.26 and glucose 5.6) was injected into the rat peritoneal cavity.…”

Section: Methodsmentioning

confidence: 99%

A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium

Sendo

Itoh

Goromaru

et al. 2003

British J Pharmacology

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1 Intravenous injection of ioxaglate (4 g iodine kg 71), an iodinated radiographic contrast medium, caused a marked protein extravasation, pulmonary oedema and a decrease in the arterial partial oxygen pressure in rats. 2 All of these reactions to ioxaglate were reversed by the pretreatment with gabexate mesilate (10 and 50 mg kg 71, 5 min prior to injection) or nafamostat mesilate (3 and 10 mg kg 71 ), in which the inhibition was complete after injection of nafamostat mesilate (10 mg kg 71 ). 3 Both gabexate mesilate and nafamostat mesilate inhibited the activity of puri®ed human lung tryptase, although the latter compound was far more potent than the former. 4 Ioxaglate enhanced the nafamostat-sensitive protease activity in the extracellular¯uid of rat peritoneal mast cell suspensions. 5 Tryptase enhanced the permeability of protein through the monolayer of cultured human pulmonary arterial endothelial cells. Ioxaglate, when applied in combination with rat peritoneal mast cells, also produced the endothelial barrier dysfunction. These eects of tryptase and ioxaglate were reversed by nafamostat mesilate. 6 Consistent with these ®ndings, immuno¯uorescence morphological analysis revealed that tryptase or ioxaglate in combination with mast cells increased actin stress ®bre formation while decreasing VE-cadherin immunoreactivity. Both of these actions of tryptase and ioxaglate were reversed by nafamostat mesilate. 7 These ®ndings suggest that tryptase liberated from mast cells plays a crucial role in the ioxaglateinduced pulmonary dysfunction. In this respect, nafamostat mesilate may become a useful agent for the cure or prevention of severe adverse reactions to radiographic contrast media. British Journal of Pharmacology (2003) 138, 959 ± 967. doi:10.1038/sj.bjp.0705121 Keywords: Radiographic contrast media; vascular hyperactivity; pulmonary edema; endothelial barrier function; tryptase; actin stress ®bre; VE-cadherin Abbreviations: BSA, bovine serum albumin; HBSS, Hank's balanced salt solution; HPAECs, human pulmonary arterial endothelial cells; PAR-2, proteinase-activated receptor-2; PBS, phosphate buered saline; RCM, radiographic contrast media; t-Boc-Phe-Ser-Arg- IntroductionIn spite of increasing use of radiographic contrast media (RCM), no eective prevention or therapy for the anaphylactoid reactions, including bronchospasm, dyspnea, laryngeal oedema and pulmonary oedema accompanying respiratory distress, induced by the intravascular injection of RCM has yet been established. The pulmonary oedema is a serious lifethreatening adverse event, although the incidence is rare. The RCM-induced pulmonary oedema is a non-cardiogenic type and appears to be related to the increase in pulmonary vascular permeability subsequent to the activation of in¯ammatory cascade or the release of a variety of chemical mediators (Bouachour et al., 1991). Although the precise mechanisms underlying the RCM-induced vascular hyperpermeability or pulmonary dysfunction remain to be clari®ed, several lines of evidence have suggested that ...

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Section: Methodsmentioning

confidence: 99%

A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium

Sendo

Itoh

Goromaru

et al. 2003

British J Pharmacology

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Roles of intracellular Ca2+ and cyclic AMP in mast cell histamine release induced by radiographic contrast media

Saito

Itoh

Yano

et al. 2003

Naunyn-Schmiedeberg's Arch Pharmacol

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Mast cell histamine release is considered to be associated with the etiology of anaphylactoid reactions to iodinated radiographic contrast media (RCM). In the present study, the effects of various ionic and non-ionic RCM on histamine release from mast cells were compared, and the possible mechanisms of the histamine release were subsequently determined. Both ionic (ioxaglate and amidotrizoate) and non-ionic (iohexol, ioversol, iomeprol, iopamidol and iotrolan) RCM increased histamine release from the dissociated rat pulmonary cells, whereby ionic materials were more potent than non-ionic agents. There was no significant correlation between the extent of histamine release and the osmolarity of each RCM solution. In addition, hyperosmotic mannitol solution (1000 mOsm/kg) caused no marked histamine release. Thus, it is unlikely that the hyperosmolarity of RCM solutions contributes to the histamine release. RCM also stimulated, but to a lesser extent, the histamine release from rat peritoneal cells. The RCM-induced histamine release from both types of cells was inhibited by dibutyl cyclic AMP or combined treatment with forskolin and 3-isobutyl-1-methylxanthine. Corresponding to these results, RCM markedly reduced the cellular cyclic AMP content. On the other hand, the removal of intracellular but not the extracellular Ca2+ attenuated the RCM-induced mast cell histamine release. From these findings, it is suggested that the decrease in cellular cyclic AMP content and an increase in intracellular Ca2+ contribute at least in part to the RCM-induced mast cell histamine release.

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Effects of Beta-Adrenergic Antagonist on Width of Nasolacrimal Drainage System Lumen

Narioka

Ohashi

2007

Journal of Ocular Pharmacology and Therapeutics

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Enhancement by Morphine of Radiographic Contrast Media-Induced Histamine Release in Rat Peritoneal Mast Cells.

Cited by 3 publications

References 11 publications

A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium

A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium

Roles of intracellular Ca2+ and cyclic AMP in mast cell histamine release induced by radiographic contrast media

Effects of Beta-Adrenergic Antagonist on Width of Nasolacrimal Drainage System Lumen

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