Enhancement by Lactosucrose of the Calcium Absorption from the Intestine in Growing Rats

Abstract

The effects of dietary lactosucrose on calcium absorption from the intestine and calcium accumulation in bones were investigated in growing female rats. The apparent calcium-45 ((45)Ca) absorption, residual (45)Ca ratio in the body, and (45)Ca accumulation in the femur and tibia of lactosucrose-supplemented rats were significantly higher than in control rats 24 h after the administration of a (45)CaCl(2) solution.

Biosynthesis of lactosylfructoside by an intracellular levansucrase from Bacillus methylotrophicus SK 21.002

“…It has the ability to maintain intestinal microflora by promoting the multiplication of Bifidobacterium, [2][3][4][5] inhibit fat accumulation, [6][7][8] and improve the absorption of intestinal calcium. 9,10 Moreover, lactosylfructoside shows a potential beneficial immunoregulatory effect. 11,12 Barely obtained by other methods, lactosylfructoside is mainly produced through an enzymatic transglycosylation reaction with sucrose and lactose as substrates.…”

Perspectives on the biotechnological production and potential applications of lactosucrose: A review

“…Rats (Honda et al, 1999;Yoneyama et al, 1992b) Dogs (Terada et al, 1992) Cats (Terada et al, 1993) Chickens ) Fujita et al, 1991aIwagaki et al, 1991;Kumemura et al, 1992;Iwagaki et al, 1993;Takumi et al, 2001;García-Cayuela et al, 2014;Li et al, 2015 Decrease of faecal pH, production of SCFAs a and gases, reduction of putrefactive products Rats (Yoneyama et al, 1992b) Dogs (Terada et al, 1992) Cats (Terada et al, 1993) Chickens Fishes (Kihara et al, 1995;Kihara & Sakata, 2001;) Kumemura et al, 1992 Enhancement of intestinal absorption of minerals Rats (Fujita et al, 1999;Kishino et al, 2006) Fishes (Kihara et al, 2007 Practical effects Prevention of obesity Rats (Mizote et al, 2009;Okuda & Han, 2001) Improvement of the immune response…”

“…Rats (Fujita et al, 1999;Kishino et al, 2006 Normalization of intestinal microflora Rats (Honda et al, 1999) Iwagaki et al, 1991Iwagaki et al, 1993 Prevention of abdominal symptoms of lactose intolerance - Oku, Kasagi, Sawatani, Fukuda & Kurimoto, 2002 a SCFAs -short chain fatty acids. (Terada et al, 1992(Terada et al, , 1993Yoneyama et al, 1992b).…”

“…Calcium distribution and accumulation in bones can be followed through 45 Ca administration into the stomach or analysed by X-ray densitometry. Rats fed with lactosucrose presented a significant increase of calcium accumulation in femur and tibia, suggesting that lactosucrose consumption can stimulate osteogenesis and help in the maintenance of bone strength (Fujita et al, 1999;Kishino et al, 2006). The ingestion of lactosucrose increased calcium retention not only in mammals but also in marine teleosts.…”

Minireview on Regulation of Intestinal Calcium Absorption

“…However, studies done in lactose-tolerant healthy adults did not show an effect of lactose on intestinal Ca absorption by using a stable strontium test under controlled metabolic conditions [88]. Lately, the use of lactosucrose in humans and animals seems to be very important in order to increase intestinal Ca 2+ absorption due to the fact that it promotes a decrease in intestinal pH increasing the solubility of Ca 2+ salts [89, 90]. Data regarding protein intake and intestinal Ca 2+ absorption indicate that dietary protein does not alter the intestinal Ca 2+ absorption and, hence, intestinal calcium absorption does not explain hypercalciuria induced by high protein intake [91].…”