Enhancement by adrenaline of ginsenoside Rg1 transport in Caco-2 cells and oral absorption in rats

Abstract

Adrenaline is effective for the stimulation of intestinal absorption of Rg1 and the enhanced absorption is mediated mainly by the interaction of adrenaline with beta2-adrenoceptors.

Active absorption of ginsenoside Rg1 in vitro and in vivo: the role of sodium-dependent glucose co-transporter 1

“…Since glucose is actively absorbed by sodium‐dependent glucose cotransporter 1 (SGLT1) in the brush‐border membrane (BBM) of intestinal epithelial cells, 10–12 SGLT1 may also be involved in the transport of some sugar analogues. In addition, our results obtained in another study 13 suggested that adrenaline (epinephrine) could be an effective absorption enhancer for Rg1 both in vivo and in vitro and that the enhancement is mediated by the interaction of adrenaline with β 2 ‐adrenoceptors. Adrenaline has been reported to have a stimulatory effect on glucose transport in the rat small intestine by regulating SGLT1 14 .…”

“…In our previous study, we demonstrated that the incubation of Caco‐2 cells with adrenaline resulted in a significant increase in the uptake and amount transported of Rg1 13 . Studies have demonstrated that adrenaline could increase the amount of SGLT1 in the BBM of intestinal epithelial cells by interacting with β‐adrenoceptors 24 .…”

Caco-2 Monolayer Permeability and Stability of Chamaelirium luteum (False Unicorn) Open-Chain Steroidal Saponins

“…The literature appears to support the hypothesis that, when absorption occurs by passive diffusion, sapogenins are more permeable than their saponin counterparts. − ,, When saponins are actively transported, they may be rendered more permeable than their passively transported sapogenin analogues . However, when the number of sugars incorporated into a saponin exceeds two, the permeability tends to decrease. ,− The clinically significant cardiac glycoside digoxin is an obvious exception to this trend. Digoxin is a steroidal saponin bearing a trisaccharide at C3 and is known to have an oral bioavailability that varies between 50 and 80% .…”

Experimental study on growth inhibition against colon cancer of animal model by combined application of ginsenoside Rg1 and chemotherapeutic medicine

“…This study shows from 3 repeated in vivo experiments: Rg 1 can inhibit the growth of colon cancer cells significantly, as well as lengthen the survival days of mice bearing SW620 tumor obviously. [10,11] It can infer from this: Rg 1 's effects of tumor growth inhibition and life extension of mice bearing tumor may be related to its abilities to inhibit the tumor angiogenesis, reduce the nutrition supply for tumor, improve the organism immunity, and promote the organism's tumor cell killing function [12,13] .…”