Enhanced visualization of blurred gray–white matter junctions in focal cortical dysplasia by voxel-based 3D MRI analysis

Huppertz, Hans‐Jürgen; Grimm, Christina; Fauser, Susanne; Kassubek, Jan; Mader, Irina; Hochmuth, A; Spreer, Joachim; Schulze‐Bonhage, Andreas

doi:10.1016/j.eplepsyres.2005.07.009

Cited by 233 publications

(249 citation statements)

References 24 publications

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“…When the lesions can be clearly visualized in MRI, the epilepsy surgery has been associated with a more favourable outcome [19]. However, the alterations of the brain tissue are often subtle and differentiating them from the normal cortex is a difficult task [20,11]. Studies regarding lesion detection by visual examination of MR images in patients undergoing epilepsy surgery have reported an accuracy of 50 − 60% at 1.5 T [17,16].…”

Section: Introductionmentioning

confidence: 99%

“…Texture analysis in MRIs of the brain has been proposed as a way of enhancing visualization of certain types of epileptogenic lesions such as focal cortical dysplasia (FCD) [13,11,1,2,4]. In some cases, these methods have shown to outperform visual assessment in discerning subtle anatomical changes, particularly in formerly cryptogenic epilepsy where the lesions produce seizures and were not detected by visual assesment of MRI [13,4].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, methods using voxel-based morphometry require the use of templates or atlases to align the patient brains among them and to compare voxel-based characteristics to the average gray matter and white matter densities of a population [23,11,9,7]. When visual features based on gray-level co-occurrence matrices are used, the number of gray-levels are often reduced to be able to compute a reliable and simple representation of the texture properties [21].…”

Section: Introductionmentioning

confidence: 99%

“…In some cases, these methods have shown to outperform visual assessment in discerning subtle anatomical changes, particularly in formerly cryptogenic epilepsy where the lesions produce seizures and were not detected by visual assesment of MRI [13,4]. In [11,1], voxel-based morphometry was used to create feature maps based on the characteristics of FCD that are visible on MRI. To characterize the texture of the regions, features are extracted from co-occurrence matrices .…”

Section: Introductionmentioning

confidence: 99%

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Epileptogenic Lesion Quantification in MRI Using Contralateral 3D Texture Comparisons

Toro

Foncubierta–Rodríguez

Gómez

et al. 2013

Advanced Information Systems Engineering

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Abstract. Epilepsy is a disorder of the brain that can lead to acute crisis and if possible an intervention can help patients. The exact localization of epileptogenic lesions influences the outcome of epilepsy surgery. Magnetic resonance (MR) imaging is clinically used for lesion detection and treatment planning, mainly through simple visual analysis. However, visual inspection in MR imaging can be highly subjective and subtle 3D structural abnormalities can be missclassified or not resected completely during the surgery. In this paper, a measurement of the differences in texture of the cerebral cortex between brain hemispheres is proposed. The 3D Riesz wavelet transform and the Hausdorff distance are used in MR T1 weighted images of the brain. A classification accuracy of 85% is obtained with 10 healthy control subjects and 8 patients with various types of epileptogenic lesions. The proposed quantitative measure of the texture alterations of these lesions allows an objective pre-surgical evaluation of patients undergoing epilepsy surgery.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Epileptogenic Lesion Quantification in MRI Using Contralateral 3D Texture Comparisons

Toro

Foncubierta–Rodríguez

Gómez

et al. 2013

Advanced Information Systems Engineering

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“…Semi-automated techniques such as voxel based morphometry (VBM), cortical thickness analysis and automated methods for identification and volumetry of subcortical structures have been developed and have the potential becoming part of a routine clinical assessment in future (Huppertz, 2005;Bernasconi, 2004;Dale, 1999;Fischl, 2000).…”

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confidence: 99%

Abstracts of the 5th Joint Meeting of the German, Austrian, and Swiss Sections of the International League Against Epilepsy Basle, May 16?19, 2007

2007

Epilepsia

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Goals, methodology:Epilepsy surgery is defined as any neurosurgical intervention with the primary goal to relieve intractable epilepsy. On the other hand essential brain regions like primary motor and sensory cortex as well as brain areas supporting language and memory functions have to be spared to avoid neurological deficits caused by the operation. Thus, the exact localization of the epileptogenic zone and of essential brain regions is crucial for the successful surgical treatment of seizures that can only be accomplished during a thorough presurgical work-up. A new noninvasive brain mapping procedure magnetoencephalography (MEG) was employed during the presurgical evaluation for localization of the epileptogenic zones and for the determination of hemispheric dominance and intrahemispheric localization of linguistic functions in patients with drug-resistant focal epilepsies.Results: The role of MEG for the localization of the epileptogenic zone in the noninvasive evaluation of patients with focal drug-resistant epilepsies:We evaluated the sensitivity and selectivity of interictal MEG versus prolonged ictal and interictal scalp video-EEG in order to identify patient groups that would benefit from preoperative MEG testing. One hundred thirteen consecutive patients with medically refractory epilepsy who underwent surgery were included. The epileptogenic region predicted by interictal and ictal Video-EEG (V-EEG) and MEG was defined in relation to the resected area as perfectly overlapping with the resected area, partially overlapping, or nonoverlapping. Using MEG, we were able to localize the resected region in a greater proportion of patients (72.3%) than with noninvasive V-EEG (40%). MEG contributed to the localization of the resected region in 58.8% of the patients with a nonlocalizing V-EEG study and 72.8% of the patients for whom V-EEG only partially identified the resected zone. Overall, MEG and V-EEG results were equivalent in 32.3% of the cases, and additional localization information was obtained using MEG in 40% of the patients. MEG was most useful for presurgical planning in patients who had either partially or nonlocalizing V-EEG results.Functional organization of interictal spike complex in medial temporal lobe epilepsies:Thirty patients with mesial temporal lobe epilepsy (MTLE) using combined MEG and EEG recordings were icluded. Spikes could be recorded in 14 patients (47%) during the 2-to 3-h MEG/EEG recording session. The MEG and EEG spikes were subjected to separate dipole analyses and the spike dipole localizations were superimposed on MRI scans. All spike dipoles could be localized to the temporal lobe with a clear preponderance in the medial region. Based on dipole orientations in MEG, patients could be classified into two groups: patients with anterior medial vertical (AMV) dipoles, suggesting epileptic activity in the mediobasal temporal lobe and patients with anterior medial horizontal (AMH) dipoles, indicating involvement of the temporal pole and the anterior parts of the lateral temporal ...

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Characteristics and Surgical Outcomes of Patients With Refractory Magnetic Resonance Imaging–Negative Epilepsies

Bien

Szinay²,

Wagner³

et al. 2009

Arch Neurol

201

171

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Enhanced visualization of blurred gray–white matter junctions in focal cortical dysplasia by voxel-based 3D MRI analysis

Cited by 233 publications

References 24 publications

Epileptogenic Lesion Quantification in MRI Using Contralateral 3D Texture Comparisons

Epileptogenic Lesion Quantification in MRI Using Contralateral 3D Texture Comparisons

Abstracts of the 5th Joint Meeting of the German, Austrian, and Swiss Sections of the International League Against Epilepsy Basle, May 16?19, 2007

Characteristics and Surgical Outcomes of Patients With Refractory Magnetic Resonance Imaging–Negative Epilepsies

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