Enhanced vibrational spectroscopy, intracellular refractive indexing for label-free biosensing and bioimaging by multiband plasmonic-antenna array

Chen, Cheng-Kuang; Chang, Ming Wen; Wu, Heng; Lee, Yao-Chang; Yen, Ta‐Jen

doi:10.1016/j.bios.2014.04.019

Cited by 23 publications

(18 citation statements)

References 48 publications

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“…The C-H vibrational resonance enhancement is achieved by applying the SEIRA technique with ASH structures that have nanoscale gaps and half-wave dipole arms that are resonant at relevant wavelengths. The enhancement factor that we have obtained is greater than the values previously reported for probing and evaluation of the C-H vibrational resonances exhibited by various biochemical analytes using the SEIRA technique [42, 45,47]. Moreover, through numerical simulations we have established matching vibrational resonances to the C-H bond stretching resonance through a Lorentz-oscillator model.…”

Section: Introductionmentioning

confidence: 48%

“…4. In this work, the expression of references [40] and [42] has been used to calculate the EF and it is defined as follows:

EF = \frac{\frac{Δ R_{2}}{N_{2}}}{\frac{Δ R_{1}}{N_{1}}} .

where N is the total number of molecules and ΔR is the relative change in the reflectance produced by the molecular resonance. N 1 and ΔR 1 correspond to measurements on unstructured surfaces, without ASH array patterning while N 2 and ΔR 2 correspond to the surface covered with an array of ASHs.…”

Section: Enhancement Factormentioning

confidence: 99%

“…In this study, we show that with the new ASH structure, zeptomole LOD values can be achieved through evaluation of the C-H vibrational resonance exhibited by E2. Other researchers have evaluated the vibrational resonances of the C-H bond in organic analytes such as polydimethylsiloxane (PDMS), 1-octadecanthiol (ODT) and poly-methyl-methacrylate (PMMA) which also reveal other molecular-bond stretch resonances in the mid-infrared region [2, 40–42]. Our designed ASH nanoantennas enable a large enhancement value of 10 5 for the C-H resonance peaks present in E2.…”

Section: Introductionmentioning

confidence: 99%

“…The vibrational resonance of the C-H bond present in PMMA has previously been enhanced using the SEIRA method [42] by a factor of 10 3 . Through experimental measurement and numerical simulations we have assayed E2, which we have previously shown to exhibit C = C and C-H bond stretching resonances in the mid-infrared region [45].…”

Section: Introductionmentioning

confidence: 99%

“…We show here that, for our novel ASH structure, which exhibits a nanoscale gap and multiple sharp corners, the proposed design, with a proper choice of shape and size, can produce a highly sensitive plasmonic sensor [40,46,48–52]. These features of ASH nanoantennas support high E-field enhancement while the asymmetric nature of the structure increases the sensitivity of the device by producing a larger relative shift in the plasmonic resonance peaks, in the presence of analyte [40–42]. …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Asymmetric split H-shape nanoantennas for molecular sensing

Mbomson¹,

Tabor²,

Lahiri³

et al. 2016

Biomed. Opt. Express

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In this paper we report on a very sensitive biosensor based on gold asymmetric nanoantennas that are capable of enhancing the molecular resonances of C-H bonds. The nanoantennas are arranged as arrays of asymmetric-split H-shape (ASH) structures, tuned to produce plasmonic resonances with reflectance double peaks within the mid-infrared vibrational resonances of C-H bonds for the assay of deposited films of the molecule 17β-estradiol (E2), used as an analyte. Measurements and numerical simulations of the reflectance spectra have enabled an estimated enhancement factor on the order of 105 to be obtained for a thin film of E2 on the ASH array. A high sensitivity value of 2335 nm/RIU was achieved, together with a figure of merit of approximately 8. Our experimental results were corroborated using numerical simulations for the C-H stretch vibrational resonances from the analyte, superimposed on the plasmonic resonances of the ASH nanoantennas.

show abstract

Section: Introductionmentioning

confidence: 48%

“…4. In this work, the expression of references [40] and [42] has been used to calculate the EF and it is defined as follows:

EF = \frac{\frac{Δ R_{2}}{N_{2}}}{\frac{Δ R_{1}}{N_{1}}} .

Section: Enhancement Factormentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Asymmetric split H-shape nanoantennas for molecular sensing

Mbomson¹,

Tabor²,

Lahiri³

et al. 2016

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

Multifunctional Chemical Sensing Platform Based on Dual‐Resonant Infrared Plasmonic Perfect Absorber for On‐Chip Detection of Poly(ethyl cyanoacrylate)

Zhou

Hui

et al. 2021

Advanced Science

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Multifunctional chemical sensing is highly desirable in industry, agriculture, and environmental sciences, but remains challenging due to the diversity of chemical substances and reactions. Surface-enhanced infrared absorption (SEIRA) spectroscopy can potentially address the above problems by ultra-sensitive detection of molecular fingerprint vibrations. Here, a multifunctional chemical sensing platform based on dual-resonant SEIRA device for sensitive and multifunctional on-chip detection of poly(ethyl cyanoacrylate) (PECA) is reported. It is experimentally demonstrated that the SEIRA sensing platform achieves multiple functions required by the PECA glue industry, including vibrational detection, thickness measurement, and in situ observation of polymerization and curing, which are usually realized by separately using a spectrometer, a viscometer, and an ellipsometer in the past. Specifically, the all-in-one sensor offers a dual-band fingerprint vibration identification, sub-nm level detection limit, and ultrahigh sensitivity of 0.76%/nm in thickness measurement, and second-level resolution in real-time observation of polymerization and curing. This work not only provides a valuable toolkit for ultra-sensitive and multifunctional on-chip detection of PECA, but also gives new insights into the SEIRA technology for multi-band, multi-functional, and on-chip chemical sensing.

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Near‐field analysis of discrete bowtie plasmonic nanoantennas

Moreno

Méndez-Lozoya

González

et al. 2019

Micro & Optical Tech Letters

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A discrete antenna is a discretized version of a traditional antenna design which enhances the antenna properties (such as field intensity, multi‐band, compact size, and low sidelobe levels) of its traditional counterpart. In this work, a classical bowtie antenna is discretized using circular elements of different sizes. Numerical simulations and near‐field optical scanning microscopy are performed on classical and discrete bowtie antennas in the infrared. Simulations show that discrete antennas have an increased bandwidth and an increased number of electric‐field hotspots and near‐field measurements confirm the increment of hotspots. These characteristics make discrete antennas potentially useful in applications where an extended region of localized electric field enhancements is of interest.

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Enhanced vibrational spectroscopy, intracellular refractive indexing for label-free biosensing and bioimaging by multiband plasmonic-antenna array

Cited by 23 publications

References 48 publications

Asymmetric split H-shape nanoantennas for molecular sensing

Asymmetric split H-shape nanoantennas for molecular sensing

Multifunctional Chemical Sensing Platform Based on Dual‐Resonant Infrared Plasmonic Perfect Absorber for On‐Chip Detection of Poly(ethyl cyanoacrylate)

Near‐field analysis of discrete bowtie plasmonic nanoantennas

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