Enhanced Transmission of Antibiotic Resistance in Campylobacter jejuni Biofilms by Natural Transformation

Bae, Junghee; Oh, Euna; Jeon, Byeonghwa

doi:10.1128/aac.04066-14

Cited by 74 publications

(53 citation statements)

References 16 publications

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“…Bae et al (2014), reported that once C. jejuni develops resistance to antibiotics, those genetic determinants can be transferred in planktonic cultures, but are most efficiently transmitted in biofilms. C. jejuni exhibits donor restriction by an unknown mechanism as it takes up free DNA from C. jejuni more readily than it does from other bacterial strains (Wang and Taylor, 1990).…”

Section: Antibiotic Resistance Determinants In Campylobactermentioning

confidence: 99%

Current and Potential Treatments for Reducing Campylobacter Colonization in Animal Hosts and Disease in Humans

2017

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Campylobacter jejuni is the leading cause of bacteria-derived gastroenteritis worldwide. In the developed world, Campylobacter is usually acquired by consuming under-cooked poultry, while in the developing world it is often obtained through drinking contaminated water. Once consumed, the bacteria adhere to the intestinal epithelium or mucus layer, causing toxin-mediated inhibition of fluid reabsorption from the intestine and invasion-induced inflammation and diarrhea. Traditionally, severe or prolonged cases of campylobacteriosis have been treated with antibiotics; however, overuse of these antibiotics has led to the emergence of antibiotic-resistant strains. As the incidence of antibiotic resistance, emergence of post-infectious diseases, and economic burden associated with Campylobacter increases, it is becoming urgent that novel treatments are developed to reduce Campylobacter numbers in commercial poultry and campylobacteriosis in humans. The purpose of this review is to provide the current status of present and proposed treatments to combat Campylobacter infection in humans and colonization in animal reservoirs. These treatments include anti-Campylobacter compounds, probiotics, bacteriophage, vaccines, and anti-Campylobacter bacteriocins, all of which may be successful at reducing the incidence of campylobacteriosis in humans and/or colonization loads in poultry. In addition to reviewing treatments, we will also address several proposed targets that may be used in future development of novel anti-Campylobacter treatments.

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Section: Antibiotic Resistance Determinants In Campylobactermentioning

confidence: 99%

Current and Potential Treatments for Reducing Campylobacter Colonization in Animal Hosts and Disease in Humans

2017

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“…A biofilm is a spatially organized structure, usually composed of one or more species of microorganisms [Bae et al, 2014]. Biofilm formation is influenced by many factors, including QS, the presence of flagella and specific surface proteins, substrate composition, and physicochemical properties of both cells and the substrate [Turonova et al, 2015].…”

Section: Qs and Biofilm Formationmentioning

confidence: 99%

Molecules Autoinducer 2 and cjA and Their Impact on Gene Expression in <b><i>Campylobacter jejuni</i></b>

et al. 2018

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Quorum sensing is a widespread form of cell-to-cell communication, which is based on the production of signaling molecules known as autoinducers (AIs). The first group contains highly species-specific N-acyl homoserine lactones (N-AHLs), generally known as AI-1, which are produced by AHL synthase. The second group, possessing the characteristic structure of a furanone ring, are known as AI-2. The enzyme responsible for their production is S-ribosylhomocysteine lyase (LuxS). In Campylobacter jejuni, AI-2 and LuxS play a role in many important processes, including biofilm formation, stress response, motility, expression of virulence factors, and colonization. However, neither the receptor protein nor the exact structure of the AI-2 molecule have been identified to date. Similarly, little is known about the possible existence of AHL-synthase producing AI-1 and its impact on gene expression. Recently, an analogue of homoserine lactone, called cjA, was isolated from a cell-free supernatant of C. jejuni strain 81–176 and from the food isolate c11. The molecule cjA particularly impacted the expression of virulence factors and biofilm formation. This review summarizes the role of AI-2 and cjA in the context of biofilm formation, motility, stress responses, and expression of virulence factors.

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“…Já o DNA extracelular (DNAe) e a proteína de ligação ao DNA são considerados imprescindíveis para o desenvolvimento da estrutura, pois são necessários para a formação adequada das micro colônias (SVENSSON et al, 2014), além de contribuir para o estabelecimento e a manutenção do biofilme (BAE et al, 2014, SVENSSON et al, 2014.…”

Section: Biofilmesunclassified

“…Esta característica compromete significativamente a eficácia da antibioticoterapia para o tratamento da campilobacteriose humana e resulta em desfechos adversos para o paciente, contribuindo assim, para o surgimento de infecções multirresistentes (HELMS et al, 2005;BAE et al, 2014). Há preocupação de que o tratamento da campilobacteriose humana fique comprometido em virtude da indisponibilidade de medicamentos eficazes para a terapêutica de infecções graves (EFSA, 2015b).…”

Section: Resistência Aos Antimicrobianosunclassified

“…O DNAe é considerado um componente estrutural importante na aquisição de resistência devido à capacidade de transformação de C. jejuni, que ao contrário de outros patógenos entéricos, tais como Salmonella e Escherichia coli, é naturalmente competente para absorver os genes presentes no DNAe, entre eles, os que conferem resistência aos antibióticos Assim, biofilmes podem ser uma importante fonte de C. jejuni resistentes, pois podem favorecer a emergência de estirpes mais especializadas mesmo sem o estímulo da pressão seletiva (BAE et al, 2014). Em adição ao uso indiscriminado de fluoroquinolonas em humanos, houve o aumento do seu uso na avicultura, levando a pressão de seleção.…”

Section: Resistência Aos Antimicrobianosunclassified

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Influência da vida séssil e planctônica no perfil de resistência antimicrobiana de Campylobacter jejuni isoladas de carcaças de frangos comercializadas no Brasil

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Enhanced Transmission of Antibiotic Resistance in Campylobacter jejuni Biofilms by Natural Transformation

Cited by 74 publications

References 16 publications

Current and Potential Treatments for Reducing Campylobacter Colonization in Animal Hosts and Disease in Humans

Current and Potential Treatments for Reducing Campylobacter Colonization in Animal Hosts and Disease in Humans

Molecules Autoinducer 2 and cjA and Their Impact on Gene Expression in <b><i>Campylobacter jejuni</i></b>

Influência da vida séssil e planctônica no perfil de resistência antimicrobiana de Campylobacter jejuni isoladas de carcaças de frangos comercializadas no Brasil

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