Enhanced transdermal delivery of indomethacin using combination of PLGA nanoparticles and iontophoresis in vivo

Tomoda, Keishiro; Terashima, Hiroto; Suzuki, Kenichi; Inagi, Toshio; Terada, Hiroshi; Makino, Kimiko

doi:10.1016/j.colsurfb.2011.11.016

Cited by 77 publications

(35 citation statements)

References 31 publications

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“…On the other hand, it has been reported that the capability of drugs to penetrate across the cornea can be significantly improved by decreasing the particle size using nanoparticles [3,9,[13][14][15]. Ophthalmic formulations containing drug nanoparticles present a possible solution to the limitations surrounding ocular drug penetration [16][17][18][19], and it is known that decreasing direct cellular stimulation and reducing the amount drug used by increasing its bioavailability are useful ways to circumvent the side effects related to drug delivery [6]. It is expected that ophthalmic drug systems using nanoparticles may provide an alternative strategy for increasing ocular drug penetration [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

“…Ophthalmic formulations containing drug nanoparticles present a possible solution to the limitations surrounding ocular drug penetration [16][17][18][19], and it is known that decreasing direct cellular stimulation and reducing the amount drug used by increasing its bioavailability are useful ways to circumvent the side effects related to drug delivery [6]. It is expected that ophthalmic drug systems using nanoparticles may provide an alternative strategy for increasing ocular drug penetration [16][17][18][19]. This review addresses the usefulness of ophthalmic formulations containing drug nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

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A New Preparation Method for Ophthalmic Drug Nanoparticles

Nagai

Ito²

2014

Pharm Anal Acta

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A New Preparation Method for Ophthalmic Drug Nanoparticles

Nagai

Ito²

2014

Pharm Anal Acta

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“…10 Therefore, strategies of combining polymer nanoparticles with active enhancement techniques for improving transdermal drug permeation have been investigated. [11][12][13] Active strategies for enhancing drug permeation include iontophoresis, electroporation, ultrasound, and microneedle pretreatment. [14][15][16][17] To some extent, these enhancement approaches can promote percutaneous drug penetration.…”

Section: Introductionmentioning

confidence: 99%

Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery

Chen¹,

Chen²,

Wang³

et al. 2015

IJN

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A synergistic approach by the combination of magnetic nanoparticles with an alternating magnetic field for transdermal drug delivery was investigated. Methotrexate-loaded silk fibroin magnetic nanoparticles were prepared using suspension-enhanced dispersion by supercritical CO 2 . The physiochemical properties of the magnetic nanoparticles were characterized. In vitro studies on drug permeation across skin were performed under different magnetic fields in comparison with passive diffusion. The permeation flux enhancement factor was found to increase under a stationary magnetic field, while an alternating magnetic field enhanced drug permeation more effectively; the combination of stationary and alternating magnetic fields, which has a massage-like effect on the skin, achieved the best result. The mechanistic studies using attenuated total reflection Fourier-transform infrared spectroscopy demonstrate that an alternating magnetic field can change the ordered structure of the stratum corneum lipid bilayers from the gel to the lipid-crystalline state, which can increase the fluidity of the stratum corneum lipids, thus enhancing skin penetration. Compared with the other groups, the fluorescence signal with a bigger area detected in deeper regions of the skin also reveals that the simulated massage could enhance the drug permeation across the skin by increasing the follicular transport. The combination of magnetic nanoparticles with stationary/alternating magnetic fields has potential for effective massage-like transdermal drug delivery.

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“…It is expected that drug systems using nanoparticles may provide an alternative strategy for increasing drug bioavailability. [19][20][21][22] On the other hand, we have also developed methods to prepare tranilast solid nanoparticles by a bead mill method, and showed that these solid nanoparticles enhance drug bioavailability. 23,24) It is possible that decreasing the amount of orally administered NSAIDs by improving their bioavailability may lead to an expansion of their usage as therapy for RA patients.…”

mentioning

confidence: 99%

“…[16][17][18] Implants fabricated using the biodegradable polymer PLGA [poly(DL-lactide-co-glycolide)] with mean particle diameters of 50-200 nm have been widely utilized as carriers for bioactive molecules and present a possible solution to limitations surrounding ocular drug penetration. [19][20][21][22] In addition, Sha et al 18) developed a newly designed oral nanotherapeutic using redox nanoparticles (RNP O ) with the potential to scavenge reactive oxygen species including nitroxide radicals for the treatment of inflammation in the gastrointestinal tract. RNP O is a core-shell-type polymeric micelle prepared by the self-assembly of methoxy-poly(ethylene glycol)-b-poly[4-(2,2,6,6-tetramethylpiperidine-1-oxyl) oxymethyl-styrene].…”

mentioning

confidence: 99%

Effect of Solid Nanoparticle of Indomethacin on Therapy for Rheumatoid Arthritis in Adjuvant-Induced Arthritis Rat

Nagai

Ito

2014

Biological & Pharmaceutical Bulletin

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We designed new oral formulations containing indomethacin (IMC) solid nanoparticles, and investigate their usefulness by evaluating bioavailability and gastrointestinal lesions. The IMC solid nanoparticles were prepared using methylcellulose (MC), 2-hydroxypropyl-β-cyclodextrin (HPβCD), and the bead mill method, and high quality dispersions containing 1.0% IMC nanoparticles were prepared (IMC nano , particle size: 76 58 nm, means S.D.). The fate of serum IMC and the induction of paw edema in adjuvant-induced arthritis (AA) rats receiving low-doses IMC nano (0.4 mg/kg) were similar to those following the administration of a therapeutic dose of conventional IMC prepared with MC and HPβCD (conventional IMC, 2 mg/kg), and the bioavailability in 0.4 mg/kg IMC nano was 5.3-fold higher in comparison with that in 2 mg/kg conventional IMC. IMC-induced gastrointestinal lesions in AA rats administered IMC nano (8 mg/kg), in consideration of bioavailability, were significantly less than for conventional IMC (40 mg/kg). On the other hand, the toxicity caused by conventional IMC and IMC nano was similar in Caco-2 cells. It is possible that the oral administration of IMC solid nanoparticles will show increased effectiveness in treating RA without causing IMC-induced gastrointestinal lesions, since the bioavailability is higher than that of conventional IMC. An oral drug delivery system using drug nanoparticles may expand the usage of NSAIDs for therapy in the inflammatory field.

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Enhanced transdermal delivery of indomethacin using combination of PLGA nanoparticles and iontophoresis in vivo

Cited by 77 publications

References 31 publications

A New Preparation Method for Ophthalmic Drug Nanoparticles

A New Preparation Method for Ophthalmic Drug Nanoparticles

Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery

Effect of Solid Nanoparticle of Indomethacin on Therapy for Rheumatoid Arthritis in Adjuvant-Induced Arthritis Rat

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