Enhanced Transcutaneous Chemodynamic Therapy for Melanoma Treatment through Cascaded Fenton-like Reactions and Nitric Oxide Delivery

A tumor microenvironment-responsive microneedle patch for chemodynamic therapy of oral squamous cell carcinoma

“…2f that at a displacement of 400 μm, the mean compression force of PVA-MN, Fe 3 O 4 -MN, and Fe 3 O 4 + VC-MN was 0.189 N, 0.372 N, and 0.315 N per needle, respectively, without buckling, which could meet the minimum force value (0.058 N) required for skin penetration according to previous studies. 32,33…”

RelB-activated GPX4 inhibits ferroptosis and confers tamoxifen resistance in breast cancer

“…In addition to ROS, TAM also induced NO production in sensitive BCa cells, another critical reactive species that functions as a cytotoxic inducer and/or adaptive signaling stimulator. Recent studies have demonstrated that NO fosters ferroptosis by depleting GSH [ 54 , 55 ]. Thus, we predict that the high NO level may induce both apoptosis and ferroptosis by promoting mitochondrial damage and depleting GSH.…”

Ferroptosis: emerging roles in lung cancer and potential implications in biological compounds

“…Nanoparticles has the ability to load chemotherapy drugs or tumor selective molecules, making them highly suitable for exploring nanoparticle-based malignant tumor treatments and combined therapies. Firstly, there is insufficient H 2 O 2 in the acidic tumor microenvironment (TME) ( Yu et al, 2023b ), and a number of nanoparticles are designed to accelerate the generation of H 2 O 2 near the tumor cell membrane ( Zhang et al, 2023a ), triggering Fenton/Fenton-like reaction to produce hydroxyl radicals (• OH) and ROS, amplifying the oxidative stress response ( Liu et al, 2023b ; Zhang et al, 2023b ), and accomplishing ferroptosis within tumor cells. Secondly, overexpression of GSH in TME clears ROS and weakens the performance of ferroptosis therapy (FT) in tumors.…”