Enhanced topical permeability of natural flavonoid baicalein through nano liposomal gel: In vitro and in vivo investigation

Majumdar, Subhabrota; Dey, Sanjay; Ganguly, Debgopal; Mazumder, Rana

doi:10.1016/j.jddst.2020.101666

Cited by 9 publications

(4 citation statements)

References 19 publications

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“…Satranidazole layered multiunit pellets were made by powder layer technology [13] using pan coating equipment that maintained all instrument parameters. Main core loading, powder application rate, type, plate speed, atomizing pressure, atomizer position, air cap type and bed temperature were taken to determine the best grades of pellets.…”

Section: Methods Of Satranidazolemultiunit Pelletsmentioning

confidence: 99%

Satranidazole-loaded chitosan/locust bean gum/xanthan gum polysaccharide composite multiunit pellets for colon targeting: in vitro–in vivo investigation

Mazumder

Mahanti

Majumdar³

et al. 2022

Beni-Suef Univ J Basic Appl Sci

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Background The colon has a significant site to deliver numerous active materials for colonic diseases. Highly biodegradable polymers hold significant promise among the several techniques available to deliver the drug to the colon. This research aimed to prepare chitosan, locust bean gum and xanthan gum polysaccharide composite satranidazole multiunit pellets for colonic release and assesses the bioavailability with pharmacokinetic parameters after administration of satranidazole raw drug compared to multiunit pellets. Satranidazole multiple unit pellets were prepared based on chitosan, locust bean gum and xanthan gum, which were inexpensive and harmless. The bioavailability study was done by crossover design in which satranidazole raw drug and test formulation was administered to six healthy white albino rats. Results The pharmacokinetic analyses were estimated using the deconvolution of the plasma profile. Compared to the satranidazole drug used as a reference, for the pellets, the maximum plasma concentration was lower (35.02 ± 3.91 ng/ml vs. 51.07 ± 1.21 ng/ml for the satranidazole drug), and the time to attain maximum concentration was 2.50 ± 0.55 h for both drugs and test formulation. Colonic drug content was significantly higher than that of free administered drug. Conclusion The results indicate the acquired pharmacokinetic studies and colonic analysis established the reliability of the pharmaceutical technique and the ability to release satranidazole at the colonic site. Graphical Abstract

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Section: Methods Of Satranidazolemultiunit Pelletsmentioning

confidence: 99%

Satranidazole-loaded chitosan/locust bean gum/xanthan gum polysaccharide composite multiunit pellets for colon targeting: in vitro–in vivo investigation

Mazumder

Mahanti

Majumdar³

et al. 2022

Beni-Suef Univ J Basic Appl Sci

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“…In contrast to commercially available formulations, the nanoliposomes loaded with baicalein demonstrated remarkable anti-inflammatory effectiveness throughout testing. Accordingly, the engineered nanoliposomal gel filled with baicalein may be employed as an effective carrier for baicalein topical administration to suppress inflammatory reactions ( 132 ).…”

Section: Pharmacokineticsmentioning

confidence: 99%

Molecular targets and therapeutic potential of baicalein: a review

Munjal,

Goel,

Gauttam

et al. 2024

dti

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Aim: Researchers using herbs and natural products to find new drugs often prefer flavonoids because of their potential as antioxidants and anti-inflammatories. The planned review addressed baicalein research findings in detail. This manuscript provides a complete review of baicalein’s potential pharmacological effects along with several molecular targets for better understanding of its therapeutic activities. Materials and methods: We targeted the review on in vitro and in vivo studies reported on baicalein. For this, the literature is gathered from the database available on search engines like PubMed, ScienceDirect, Scopus, and Google Scholar up to 21 December 2023. The keywords “Scutellaria baicalensis”, “Oroxylum indicum”, “Neuroprotective”, “Cardioprotective”, “Toxicity studies”, and “Baicalein” were used to fetch the content. Results: Baicalein’s molecular receptor binding approach has shown anticancer, antidiabetic, antimicrobial, antiaging, neuroprotective, cardioprotective, respiratory protective, gastroprotective, hepatic protective, and renal protective effects. The synergistic effects of this drug with other selective herbs are also contributed towards significant therapeutic potential. Conclusion: This systematic review article from a contemporary and scientific perspective offers fresh insight into S. baicalensis, O. indicum, and its bioactive component baicalein as a potential complementary medicine. Baicalein may be transformed into more efficacious and acceptable evidence-based medicine. However, we recommend more clinical and mechanistic approaches to confirm safety and efficacy of baicalein.

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“…The IR absorption peak of docetaxel trihydrate was taken in the range of 4000cm − 1 to 400 cm − 1 using the KBr disc method. The major peak was reported for the evaluation of purity [Majumdar et al 2020, Kar et al 2020].…”

Section: Fabrication Of Mesoporous Silica Loaded Docetaxel Trihydrate...mentioning

confidence: 99%

Fabrication, Design and In-vivo investigation of Mesoporous Silica Based Docetaxel Trihydrate Nanoparticles for Colonic Drug Delivery

Majumdar¹,

Mondal²,

Bose³

et al. 2023

Preprint

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Background Mesoporous silica-loaded docetaxel trihydrate nanoparticles are the potential to target drug delivery toward a specific region with high stability and predictable release at the target region. They have large surface areas and mesoporous structures with large pore volumes, leading to high bioavailability and therapeutic efficacy at the disease site. This study demonstrates how nanoparticles can be prepared using an emulsion technique. Results The ratios of eudragit S100 to eudragit L100 polymers, along with phosphatidylcholine, were varied according to the response surface methodology. DSC and FTIR studies showed that mesoporous silica particles were successful. All formulations had average particle sizes ranging from 70.65 to 143.01nm, with a range of zeta potential from 17.6 ± 026 to 21 ± 011. In-vitro drug delivery studies were achieved for all formulations with a zeta potential of 17.6 ± 026 to 21 ± 011. After oral administration of the docetaxel, plasma levels were measured in vivo bioavailability testing of docetaxel. Docetaxel nanosuspension had a significantly higher Cmax amount than docetaxel micro-suspension (98.03 ± 23.40 ng/ml and 213.67 ± 72.21 ng/ml, respectively, with tmax 45 minutes). Docetaxel was more bioavailable in nanosuspension formulations, according to a bioavailability test of rats. Conclusion The results suggested that the mesoporous silica could be a great potential nanocarrier in colonic delivery with optimal drug content and controlled release docetaxel trihydrate.

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Enhanced topical permeability of natural flavonoid baicalein through nano liposomal gel: In vitro and in vivo investigation

Cited by 9 publications

References 19 publications

Satranidazole-loaded chitosan/locust bean gum/xanthan gum polysaccharide composite multiunit pellets for colon targeting: in vitro–in vivo investigation

Satranidazole-loaded chitosan/locust bean gum/xanthan gum polysaccharide composite multiunit pellets for colon targeting: in vitro–in vivo investigation

Molecular targets and therapeutic potential of baicalein: a review

Fabrication, Design and In-vivo investigation of Mesoporous Silica Based Docetaxel Trihydrate Nanoparticles for Colonic Drug Delivery

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