Enhanced thrombin generation in normal and hypertensive pregnancy

Boer, Karin; Cate, J. W. Ten; Sturk, Augueste; Borm, J. J. J.; Treffers, P.E.

doi:10.1016/0002-9378(89)90096-3

Cited by 226 publications

(122 citation statements)

References 17 publications

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“…Increased levels of coagulation factors are due to increased protein synthesis mediated by the rising estrogen levels. In in vitro experiments, pregnant plasma has been demonstrated to be capable of increased thrombin generation [16]. Thus, pregnancy is a prothrombotic state.…”

Section: Hemostatic Profilementioning

confidence: 99%

Physiological Changes in Hematological Parameters During Pregnancy

Chandra

Tripathi

Mishra

et al. 2012

Indian J Hematol Blood Transfus

255

221

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Section: Hemostatic Profilementioning

confidence: 99%

Physiological Changes in Hematological Parameters During Pregnancy

Chandra

Tripathi

Mishra

et al. 2012

Indian J Hematol Blood Transfus

255

221

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“…The principal anticoagulant mechanism inhibiting TF activation pathway is tissue factor pathway inhibitor (TFPI), which mRNA is highly expressed in the macrophages in the villi in term placenta 19 . Similarly, high TF concentrations have been detected in the fetal membranes (mainly the amnion) and amniotic fluid 7,[20][21][22][23] . TFPI has been found in amniotic fluid as well 20 , but it is not clear if the presence of TF and its natural inhibitor is related to coagulation per se or is somehow connected with embryonic development 24 .…”

Section: What Are the Changes In The Coagulation System During Normalmentioning

confidence: 95%

“…The changes in the coagulation system during gestation are considered to be adaptive mechanisms and are aimed to: 1) the prevention of bleeding at the time of trophoblast implantation and the delivery of the fetus; 2) allow the laminar flow and the intervillous space; and 3) seal amniotic fluid leak and reduce obstetrical bleeding [3][4][5][6][7] . Of interest, the fetus is somewhat less involved and its coagulation system develops during gestation, and this subject is beyond the scope of this review.…”

Section: What Are the Changes In The Coagulation System During Normalmentioning

confidence: 99%

“…However, labor at term increases significantly the maternal plasma immunoreactive TF concentration in comparison to the non-pregnant state 20 . In addition to the changes in TF, normal pregnancy is associated with increased thrombin generation 3,8 , as determined by the elevation of maternal concentrations of fibrinopeptide A, prothrombin fragments (PF) 1 and 2, and thrombin-antithrombin (TAT) III complexes 7,[26][27][28] . The concentration of these complexes further increases during and after normal parturition 27,29 , and subsequently decreases during the puerperium 27, 29 .…”

Section: What Are the Changes In The Coagulation System During Normalmentioning

confidence: 99%

See 1 more Smart Citation

Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromes

Mastrolia

Mazor

Loverro

et al. 2014

Preprint

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View the peer-reviewed version (peerj.com/articles/653), which is the preferred citable publication unless you specifically need to cite this preprint. Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromesObstetrical complications including preeclampsia, fetal growth restriction, preterm labor, preterm prelabor rupture of membranes and fetal demise are all the clinical endpoint of several underlying mechanisms (i.e. infection inflammation, thrombosis, endocrine disorder, immunologic rejection, genetic, and environmental), therefore, they may be regarded as syndromes. Placental vascular pathology and increased thrombin generation were reported in all of these obstetrical syndromes. Moreover, elevated concentrations of thrombin-antithrombin III complexes and changes in the coagulation as well as anticoagulation factors can be detected in the maternal circulation prior to the clinical development of the disease in some of these syndromes. In this review, we will assess the changes in the hemostatic system during normal and complicated pregnancy in maternal blood, maternal-fetal interface and amniotic fluid, and describe the contribution of thrombosis and vascular pathology to the development of the great obstetrical syndromes.PeerJ PrePrints | http://dx.doi.org/10.7287/peerj.preprints.487v1 | CC-BY 4.0 Open Access |

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“…13 Several pathophysiological pathways have been implicated in the development of preeclampsia: abnormal implantation, 13 oxidative stress, 14 inflammatory mechanisms, 15;16 endothelial dysfunction, 13 renin-angiotensin system, 17;18 and activation of thrombosis. 19 It is believed that inhibition of angiogenic factors or an angiogenic imbalance between pro-angiogenic factors and anti-angiogenic factors can result in preeclampsia. 20 Literature supports a role for abnormal angiogenesis in the development of preeclampsia.…”

Section: Commentmentioning

confidence: 99%

Long-term Alterations in Maternal Plasma Proteome After sFlt1-induced Preeclampsia in Mice

Bytautiene

Bulayeva

Bhat

et al. 2014

Obstetric Anesthesia Digest

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Objective-Preeclampsia (PE) is associated with long-term adverse maternal health, such as cardiovascular (CVD) and metabolic diseases. The objective of this study was to determine whether PE in a well characterized animal model induced by over-expression of sFlt-1 results in alterations in the maternal circulating proteome that persist long after delivery.Methods-CD-1 mice at day 8 of gestation were injected with adenovirus carrying sFlt1 or the murine IgG2α Fc fragment as control. Depleted maternal plasma was analyzed 6 months after delivery by label-free liquid chromatography -mass spectrometry assay. The tandem MS data were searched against a mouse database and the resultant intensity data were used to compare abundance of proteins across disease/control plasma pool (MaxQuant/Mascot). Results were analyzed using Ingenuity Pathways Analysis (IPA). Right-tailed Fisher's exact test was used to calculate a P-value.Results-Out of 150 proteins common for both groups, IPA determined 105 proteins ready for analysis. Diseases and disorders analysis showed significant enrichment of proteins associated with CVD. Within this cluster, the most abundant proteins were associated with vascular disease, atherosclerosis and atherosclerotic lesions. Other top disease clusters were inflammatory response, organismal injury and abnormalities, hematological and metabolic disease.Conclusions-Exposure to sFlt1-induced preeclampsia alters multiple biological functions in mothers that persist later in life. Our results suggest that some of the long term adverse outcomes associated with preeclampsia may actually be a consequence of an underlying predisposition. If similar results are found in humans, developing preventive strategies for preeclampsia should also improve long term maternal health.

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Enhanced thrombin generation in normal and hypertensive pregnancy

Cited by 226 publications

References 17 publications

Physiological Changes in Hematological Parameters During Pregnancy

Physiological Changes in Hematological Parameters During Pregnancy

Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromes

Long-term Alterations in Maternal Plasma Proteome After sFlt1-induced Preeclampsia in Mice

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