Enhanced Therapeutic Potential of Nano-Curcumin Against Subarachnoid Hemorrhage-Induced Blood–Brain Barrier Disruption Through Inhibition of Inflammatory Response and Oxidative Stress

Zhang, Zongyong; Jiang, Ming; Fang, Jie; Yang, Mo; Zhang, Shuai; Yin, Yanxin; Li, Dawei; Mao, Leilei; Fu, Xin; Hou, Ya‐Jun; Fu, Xiaoting; Fan, Cundong; Sun, Bo

doi:10.1007/s12035-015-9635-y

Cited by 132 publications

(117 citation statements)

References 44 publications

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“…The BBB permeability was measured by evans blue (E8010, Solaribio) dye extravasation at 48 and 72 h following SAH as reported previously [22]. In brief, after anesthesia with chloral hydrate, rats in each group received 2% EB (5 ml/kg) through intravenous injection.…”

Section: Methodsmentioning

confidence: 99%

Roflumilast Reduces Cerebral Inflammation in a Rat Model of Experimental Subarachnoid Hemorrhage

et al. 2017

Inflammation

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Roflumilast, a selective inhibitor for PDE4, is approved by FDA as an anti-inflammation drug for treatment of chronic obstructive pulmonary disease (COPD). This study investigates the effects of roflumilast on cerebral inflammation in the rat SAH model. Here, we show that subcutaneous administration of roflumilast (3 mg/kg) significantly improved the neurological deficits. Measurement of evans blue extravasation and brain water content revealed a significant reduction of blood-brain barrier permeability and brain edema. Importantly, roflumilast treatment remarkably decreased levels of IL-1β, IL-6, and TNF-α and the number of apoptotic neurons in the brain after SAH. These results indicate that roflumilast is effective in treating cerebral inflammation following SAH.

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Section: Methodsmentioning

confidence: 99%

Roflumilast Reduces Cerebral Inflammation in a Rat Model of Experimental Subarachnoid Hemorrhage

et al. 2017

Inflammation

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“…In our future research, a BBB model and inhibitors associated with the signaling pathways will be applied to further study the underling mechanism of its activity. 23,64 It is noteworthy that, in this study, the lowtoxic Cur/SLNs-HU-211 nanoparticles displayed excellent Figure 10 schematic representation of the mechanisms by which cur/slNs-hU-211 crosses the BBB for the cOrT-induced major depression model. Notes: after intraperitoneal injection of cur/slNs-hU-211 into the mice with major depression, the nanoparticles accumulated at brain.…”

Section: Discussionmentioning

confidence: 72%

“…[21][22][23] Meanwhile, HU-211 was also hindered by its low stability in biological systems and poor cellular uptake. To circumvent these drawbacks, nanotechnology-based drug delivery systems are promising approaches to improve Cur and HU-211 for better use in major depression treatment.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

Zhu

Wang

et al. 2016

IJN

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Major depression is a complex neuropsychiatric disorder with few treatment approaches. The use of nontargeted antidepressants induced many side effects with their low efficacy. A more precise targeting strategy is to develop nanotechnology-based drug delivery systems; hence, we employed solid lipid nanoparticles (SLNs) to encapsulate HU-211 and curcumin (Cur). The antidepressant effects of the dual-drug nanoparticles (Cur/SLNs-HU-211) for major depression treatment were investigated in corticosterone-induced cellular and animal models of major depression. Cur/SLNs-HU-211 can effectively protect PC12 cells from corticosterone-induced apoptosis and can release more dopamine, which may be associated with the higher uptake of Cur/SLNs-HU-211 shown by cellular uptake behavior analysis. Additionally, Cur/SLNs-HU-211 significantly reduced the immobility time in forced swim test, enhanced fall latency in rotarod test, and improved the level of dopamine in mice blood. Cur/SLNs-HU-211 can deliver more Cur to the brain and thus produce a significant increase in neurotransmitters level in brain tissue, especially in the hippocampus and striatum. The results of Western blot and immunofluorescence revealed that Cur/SLNs-HU-211 can significantly enhance the expression of CB1, p-MEK1, and p-ERK1/2. Our study suggests that Cur/SLNs-HU-211 may have great potential for major depression treatment.

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“…Antidepressant treatment is associated with reductions in the expression of the proinflammatory cytokines IL-10, TNFα, and CCL2 36 . Conversely, antidepressant effects of anti-inflammatory medications have also been demonstrated 37 .…”

Section: Depression and Inflammation In The General Populationmentioning

confidence: 99%

Roles of Inflammation and Depression in the Development of Gestational Diabetes

Robakis

Aasly

Williams

et al. 2017

Curr Behav Neurosci Rep

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Inflammation, the body’s response to harmful external agents, has long been found to be associated with depressive symptoms. The relationship between inflammation and depression is well established in the general population of people with depression, but is less so among perinatal women. Depression in the perinatal period is a common disorder, however available data do not indicate that there is a specific inflammatory picture associated with perinatal depression. We suggest that perinatal depression may be a heterogeneous construct, and that inflammation may be relevant to it in the context of other inflammatory morbidities of pregnancy. In this review we explore the available support for the hypothesis that inflammation associated with depression can represent a precipitating insult for the development of gestational diabetes, a known inflammatory morbidity of pregnancy.

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Enhanced Therapeutic Potential of Nano-Curcumin Against Subarachnoid Hemorrhage-Induced Blood–Brain Barrier Disruption Through Inhibition of Inflammatory Response and Oxidative Stress

Cited by 132 publications

References 44 publications

Roflumilast Reduces Cerebral Inflammation in a Rat Model of Experimental Subarachnoid Hemorrhage

Roflumilast Reduces Cerebral Inflammation in a Rat Model of Experimental Subarachnoid Hemorrhage

Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

Roles of Inflammation and Depression in the Development of Gestational Diabetes

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