2007
DOI: 10.1007/s10157-006-0456-1
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Enhanced TGF-b/Smad signaling in the early stage of diabetic nephropathy is independent of the AT1a receptor

Abstract: Our results suggest that the complete blockade of the AT1a-mediated pathway has a minimal effect on the enhanced TGF-beta/Smad signaling in the early stage of DN, at least in the AT1a(-/-) model.

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Cited by 18 publications
(13 citation statements)
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“…In a previous study, TGF‐β expression in the glomeruli was increased significantly not only in diabetic AT 1a +/+ mice, but also in dietetic AT 1a −/− mice and AT 1a receptor activation was demonstrated to mediate approximately 80% of the renal effects of AngII 33 . Whether increases in TGF‐β are mediated by AT 1 receptors or AT 1 receptor‐independent mechanisms remains unknown 34 …”
Section: Discussionmentioning
confidence: 94%
“…In a previous study, TGF‐β expression in the glomeruli was increased significantly not only in diabetic AT 1a +/+ mice, but also in dietetic AT 1a −/− mice and AT 1a receptor activation was demonstrated to mediate approximately 80% of the renal effects of AngII 33 . Whether increases in TGF‐β are mediated by AT 1 receptors or AT 1 receptor‐independent mechanisms remains unknown 34 …”
Section: Discussionmentioning
confidence: 94%
“…As hyperglycaemia and HNE can trigger multiple signalling pathways [22,[26][27][28][29], in order to confirm the direct effect of WNT activation on renal fibrogenesis in diabetic nephropathy, primary HRPTC were exposed to WNT3A-conditioned medium (WCM); plain L cell conditioned medium (LCM) was used as a control. As shown by western blot analysis, WCM increased cytosolic and nuclear β-catenin levels significantly compared with LCM ( Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Increased GCR sensitivity can be considered as an indicator of excessive activity of GC which is a plausible contributor to obesity and insulin resistance. FFA induces the over-expression of TGFBRII as noted in diabetic kidney disease [100] and it increases the expressions of proto-oncogenes and SMAD3 in TGFB signalling process [101]. TGFB induces as well as gets activated by ROS intermediates [102], [65].…”
Section: Discussionmentioning
confidence: 99%