Enhanced T cell receptor specificity through framework engineering
Aaron M. Rosenberg,
Cory M. Ayres,
Angélica V. Medina-Cucurella
et al.
Abstract:Development of T cell receptors (TCRs) as immunotherapeutics is hindered by inherent TCR cross-reactivity. Engineering more specific TCRs has proven challenging, as unlike antibodies, improving TCR affinity does not usually improve specificity. Although various protein design approaches have been explored to surmount this, mutations in TCR binding interfaces risk broadening specificity or introducing new reactivities. Here we explored if TCR specificity could alternatively be tuned through framework mutations … Show more
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