2001
DOI: 10.1016/s0165-5728(01)00293-4
|View full text |Cite
|
Sign up to set email alerts
|

Enhanced susceptibility to Theiler's virus-induced demyelinating disease in perforin-deficient mice

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
42
3

Year Published

2003
2003
2009
2009

Publication Types

Select...
7
1

Relationship

2
6

Authors

Journals

citations
Cited by 30 publications
(47 citation statements)
references
References 48 publications
2
42
3
Order By: Relevance
“…3 to 5). The importance of CD8 ϩ T cells in viral resolution is consistent with previous reports of mice with resistant backgrounds (38,45,47). However, it is also possible that deficiencies in virus-specific CD4 ϩ T-cell and antibody responses in P1-Tg mice contribute to the lack of viral clearance, as these immune responses play a role in TMEV clearance from the CNS, especially during the early stages of viral infection (6,22,40,43).…”
Section: Most Epitopes Recognized By Cns-infiltrating Cd4supporting
confidence: 88%
See 1 more Smart Citation
“…3 to 5). The importance of CD8 ϩ T cells in viral resolution is consistent with previous reports of mice with resistant backgrounds (38,45,47). However, it is also possible that deficiencies in virus-specific CD4 ϩ T-cell and antibody responses in P1-Tg mice contribute to the lack of viral clearance, as these immune responses play a role in TMEV clearance from the CNS, especially during the early stages of viral infection (6,22,40,43).…”
Section: Most Epitopes Recognized By Cns-infiltrating Cd4supporting
confidence: 88%
“…Despite numerous studies, the relationship between viral persistence and the pathogenesis of demyelinating disease remains unclear. The removal of either B or T cells from resistant mice results in elevated viral persistence but increased demyelination with/without marginal clinical symptoms or encephalitis, a different neurological disease often without demyelination (6,22,41,42,45,47). These results imply that demyelination and/or the development of demyelinating disease is tightly associated with viral persistence.…”
mentioning
confidence: 99%
“…ϩ T cell effector function as well as in MHC class I Ag presentation display enhanced susceptibility to disease (22,(51)(52)(53)(54). In contrast, other studies maintain a pathogenic role for CD8 ϩ T cells based on the lack of clinical signs of disease after infection of mice lacking molecules involved in CD8 ϩ T cell function (55,56).…”
Section: Discussionmentioning
confidence: 99%
“…npg regulate some immune responses [13][14][15]. The main mechanism for this effect is believed to be that CTLs can rapidly eliminate dendritic cells (DC) loaded with specific antigen, in a perforin-dependent manner, to restrict the immune response.…”
Section: Discussionmentioning
confidence: 99%
“…The patients would die within a few months of the onset of symptoms if not treated appropriately. Extensive studies have revealed that perforin can downregulate T cells-mediated immune responses in lupus [14] and Theiler's virus-induced demyelinating disease [15]. In addition to its cytotoxic function in CD8 + T cells, these results suggest that perforin may play other roles in T cells function during different types of immune responses, and that it is more than just an effector molecule in the immune response [16].…”
Section: Introductionmentioning
confidence: 98%