Enhanced Susceptibility to Salmonella Infection in Streptomycin-Treated Mice*

Bohnhoff, Majorie; Miller, Claire A.

doi:10.1093/infdis/111.2.117

Cited by 201 publications

(120 citation statements)

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“…However, one of the earliest described features of the effect of antibiotics on the gut was the loss of colonization resistance (i.e., the loss of "competitive exclusion," refs. 13,14). The loss was manifested by the much greater ease of colonization and disease caused by Salmonella immediately following antibiotic treatment.…”

Section: Microbial Community-wide Effects Of Antibioticsmentioning

confidence: 99%

Antibiotics and the gut microbiota

Modi¹,

Collins²,

Relman³

2014

J. Clin. Invest.

538

396

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Section: Microbial Community-wide Effects Of Antibioticsmentioning

confidence: 99%

Antibiotics and the gut microbiota

Modi¹,

Collins²,

Relman³

2014

J. Clin. Invest.

538

396

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“…However, the administration of streptomycin in drinking water disrupts the endogenous intestinal flora and renders mice susceptible to Salmonella colitis (Bohnhoff and Miller 1962;Barthel et al 2003). Specialist and generalist Salmonella strains differ in their ability to cause enteritis in the streptomycin-treated mouse model, although substantial strain-tostrain differences within serovars are observed (Suar et al 2006).…”

Section: Comparative Zoologymentioning

confidence: 99%

Host Specificity of Bacterial Pathogens

Bäumler

Fang

2013

Cold Spring Harbor Perspectives in Medicine

165

134

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“…I n fact, it is difficult to establish non-indigenous bacteria, for example staphylococci, Proteus, and Pseudomonas in the gut of many species of animal. Freter (1956) and Bohnhoff & Miller (1962) found that by altering the normal flora with antibiotics, they could then establish many pathogenic species of organisms in the treated gut. I n the germ-free animal all the organisms mentioned are readily established.…”

Section: The Role Of the Intestinal Jora In Preventing The Establishmmentioning

confidence: 99%

The relationship between the host and its intestinal microflora

Schaedler

1973

Proc. Nutr. Soc.

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During the past decade, there has been an increased interest in the microflora of the gut and its effects on the host organism. Several factors have contributed to this development. These include more sophisticated techniques for isolating and enumerating the anaerobic bacteria, the availability of germ-free and pathogenfree animals as experimental models, use of antibiotics with selective action, and better understanding of the metabolism of gut micro-organisms.Much of the preliminary work has been done in animal models, and recent work in man indicates that similar situations exist in the two systems. Through the use of experimental models, it has been shown that the gastro-intestinal flora (I) affects the growth and development of the animal, ( 2 ) influences the nutritional requirements, (3) affects the morphogenesis of the gastro-intestinal tract, (4) modifies, through metabolic activity, both endogenous and exogenous substances presented to the gastro-intestinal tract and ( 5 ) plays an important role in preventing other 'foreign' organisms from becoming established in the gut.One can now approach with greater confidence the symbiotic and parasitic aspects of the relationship between the gut flora and the host animal.

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Enhanced Susceptibility to Salmonella Infection in Streptomycin-Treated Mice*

Cited by 201 publications

References 0 publications

Antibiotics and the gut microbiota

Antibiotics and the gut microbiota

Host Specificity of Bacterial Pathogens

The relationship between the host and its intestinal microflora

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