Enhanced Survival of Bone–Marrow‐Derived Pluripotent Stem Cells in an Animal Model of Auditory Neuropathy

Matsuoka, Akihiro; Kondo, Takako; Miyamoto, Richard T.; Hashino, Eri

doi:10.1097/mlg.0b013e31806bf282

Cited by 69 publications

(69 citation statements)

References 15 publications

(19 reference statements)

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“…The extent of integration of mesenchymal stem cells into host tissues after cochlear transplantation has differed between studies. Although Sharif et al [43] described integration of bone marrow-derived stromal cells into mouse cochlear tissues following transplantation via a lateral wall cochleostomy, Matsuoka et al [44] reported no integration of mesenchymal stem cells following transplantation via a lateral wall cochleostomy but extensive integration after injection directly into cochlear tissues. Direct transplantation of stem cells into cochlea tissues has not yet been examined in mice because of technical difficulties relating to the size of the murine cochlea.…”

Section: Discussionmentioning

confidence: 99%

Functional Effects of Adult Human Olfactory Stem Cells on Early-Onset Sensorineural Hearing Loss

et al. 2011

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Transplantation of exogenous stem cells has been proposed as a treatment to prevent or reverse sensorineural hearing loss. Here, we investigate the effects of transplantation of adult human olfactory mucosa-derived stem cells on auditory function in A/J mice, a strain exhibiting early-onset progressive sensorineural hearing loss. Recent evidence indicates that these stem cells exhibit multipotency in transplantation settings and may represent a subtype of mesenchymal stem cell. Olfactory stem cells were injected into the cochleae of A/J mice via a lateral wall cochleostomy during the time period in which hearing loss first becomes apparent. Changes in auditory function were assessed 1 month after transplantation and compared against animals that received sham injections. Hearing threshold levels in stem cell-transplanted mice were found to be significantly lower than those of sham-injected mice (p < .05) for both click and pure tone stimuli. Transplanted cells survived within the perilymphatic compartments but did not integrate into cochlear tissues. These results indicate that transplantation of adult human olfactory mucosa-derived stem cells can help preserve auditory function during early-onset progressive sensorineural hearing loss. STEM CELLS 2011;29:670-677 Disclosure of potential conflicts of interest is found at the end of this article.

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Section: Discussionmentioning

confidence: 99%

Functional Effects of Adult Human Olfactory Stem Cells on Early-Onset Sensorineural Hearing Loss

et al. 2011

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“…They have also shown that neural progenitors derived from mouse embryonic stem cells can integrate into a damaged cochlear nerve and send out neural processes toward the cochlea (Corrales et al, 2006). Several other groups have explored the use of mouse embryonic stem cells, bone marrow cells, or neural stem cells for repopulation of the cochlear nerve, organ of Corti, and lateral cochlear wall (Hildebrand et al, 2005;Lang et al, 2006;Matsuoka, Kondo, Miyamoto, & Hashino, 2006;Matsuoka, Kondo, Miyamoto, & Hashino, 2007).…”

Section: Stem Cell Transplantationmentioning

confidence: 99%

Genetic and pharmacological intervention for treatment/prevention of hearing loss

Cotanche

2008

Journal of Communication Disorders

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Twenty years ago it was first demonstrated that birds could regenerate their cochlear hair cells following noise damage or aminoglycoside treatment. An understanding of how this structural and functional regeneration occurred might lead to the development of therapies for treatment of sensorineural hearing loss in humans. Recent experiments have demonstrated that noise exposure and aminoglycoside treatment lead to apoptosis of the hair cells. In birds, this programmed cell death induces the adjacent supporting cells to undergo regeneration to replace the lost hair cells. Although hair cells in the mammalian cochlea undergo apoptosis in response to noise damage and ototoxic drug treatment, the supporting cells do not possess the ability to undergo regeneration. However, current experiments on genetic manipulation, gene therapy, and stem cell transplantation suggest that regeneration in the mammalian cochlea may eventually be possible and may 1 day provide a therapeutic tool for hearing loss in humans.Learning outcomes-The reader should be able to: (1) Describe the anatomy of the avian and mammalian cochlea, identify the individual cell types in the organ of Corti, and distinguish major features that participate in hearing function, (2) Demonstrate a knowledge of how sound damage and aminoglycoside poisoning induce apoptosis of hair cells in the cochlea, (3) Define how hair cell loss in the avian cochlea leads to regeneration of new hair cells and distinguish this from the mammalian cochlea where there is no regeneration following damage, and (4) Interpret the potential for new approaches, such as genetic manipulation, gene therapy and stem cell transplantation, could provide a therapeutic approach to hair cell loss in the mammalian cochlea.

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“…Indeed, grafted NI-hMSCs migrate into the spiral ganglion where they expressed the neuron-specific marker, NeuN 37 . A study on transplantation of undifferentiated mouse BMSCs into normal and ouabain-treated gerbil cochleae and determination of their migratory patterns has demonstrated that survival of transplanted MSCs into the modiolus of the cochlea may result in regeneration of damaged SGNs 38 . In a similar study, rats with transplanted MSCs in the lateral wall demonstrated a significantly higher hearing recovery comparing to negative controls suggesting that MSCs transplantation results in hearing recovery through the repair of injured cochlear fibrocytes 39 .…”

Section: Hearing Recovery After Transplantation Of Mscsmentioning

confidence: 99%

Comparison of Three Types of Mesenchymal Stem Cells (Bone Marrow, Adipose Tissue, and Umbilical Cord-Derived) as Potential Sources for Inner Ear Regeneration

Mahmoudian-Sani

Mehri-Ghahfarrokhi

Hashemzadeh‐Chaleshtori

et al. 2017

The International Tinnitus Journal

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In this review, we compared the potential of mesenchymal stem cells derived from bone marrow, adipose tissue and umbilical cord as suitable sources for regeneration of inner ear hair cells and auditory neurons. Our intensive literature search indicates that stem cells in some of adult mammalian tissues, such as bone marrow, can generate new cells under physiological and pathological conditions. Among various types of stem cells, bone marrow-derived mesenchymal stem cells are one of the most promising candidates for cell replacement therapy. Mesenchymal stem cells have been reported to invade the damaged area, contribute to the structural reorganization of the damaged cochlea and improve incomplete hearing recovery. We suggest that bone marrow-derived mesenchymal stem cells would be more beneficial than other mesenchymal stem cells.

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Enhanced Survival of Bone–Marrow‐Derived Pluripotent Stem Cells in an Animal Model of Auditory Neuropathy

Abstract: These findings may have important clinical implications as a means of delivering MSCs in the cochlea for stem-cell replacement therapy. Survival of transplanted MSCs into the modiolus of the cochlea may result in regeneration of damaged SGNs.

Cited by 69 publications

References 15 publications

Functional Effects of Adult Human Olfactory Stem Cells on Early-Onset Sensorineural Hearing Loss

Functional Effects of Adult Human Olfactory Stem Cells on Early-Onset Sensorineural Hearing Loss

Genetic and pharmacological intervention for treatment/prevention of hearing loss

Comparison of Three Types of Mesenchymal Stem Cells (Bone Marrow, Adipose Tissue, and Umbilical Cord-Derived) as Potential Sources for Inner Ear Regeneration

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