Enhanced sun protection of nano‐sized metal oxide particles over conventional metal oxide particles: An <i>in vitro</i> comparative study

Singh, Priyanka; Nanda, Arun

doi:10.1111/ics.12124

Cited by 79 publications

(48 citation statements)

References 12 publications

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“…For example, titanium dioxide (TiO 2 ) nanoparticles (NPs) have been used as UV-blocking filters for their enhanced protective effect against UV-induced damages and their ability to improve texture and spreadability compared with other conventional metal oxide particles (Singh and Nanda, 2014). Moreover, sunscreens with micronized TiO 2 particles reduce risks of sunburn caused by UVB light, possibly through the induction of immune modulators (e.g.…”

Section: Introductionmentioning

confidence: 99%

Role of fatty acid composites in the toxicity of titanium dioxide nanoparticles used in cosmetic products

et al. 2016

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-It has been recognized that the use of nanoparticles (NPs) in the cosmetic industry results in products with better efficacy and functionality. However, recent advances in molecular toxicology have revealed that NP exposure can promote cytotoxicity and oxidative damage, which has raised health concerns in the use of NPs in personal care products. Nevertheless, the mechanistic basis for the toxicity and safety of cosmetic NPs is poorly understood. The goal of the study was to determine the cytotoxicity and intracellular distribution of titanium dioxide (TiO 2 ) NPs containing fatty acid composites (palmitoleic acid, palmitic acid, stearic acid and oleic acid) commonly used in cosmetic products. Two types of cells, human fibroblast skin cells and adenocarcinoma lung cells, were exposed to either bare TiO 2 NPs or TiO 2 NPs mixed with fatty acids for up to 48 hr. NMR analysis confirmed that the fatty acid composites remained in the NPs after wash. The cytotoxicity of TiO 2 NPs was determined by cell viability measurement using quantitative confocal microscopy, and the localization of two different forms of TiO 2 NPs were assessed using electron spectroscopic imaging with transmission electron microscopy. TiO 2 NPs containing fatty acids posed significantly reduced cytotoxicity (80-88% decreases) than bare NPs in both cell types. Furthermore, there was less intracellular penetration of the NPs containing fatty acid composites compared with bare NPs. These results provide important insights into the role of fatty acids in protecting the cells from possible toxicity caused by NPs used in the production of cosmetic products.

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Section: Introductionmentioning

confidence: 99%

Role of fatty acid composites in the toxicity of titanium dioxide nanoparticles used in cosmetic products

et al. 2016

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“…Due to ethical concerns associated with in vivo method of SPF determination, in vitro method is now largely accepted and has several advantages over in vivo method such as reproducibility, simplicity, no need of human volunteer, etc. As then nanosize titanium dioxide and zinc oxide are widely use in commercial sunscreen formulation as SPF enhancer [6]. In 1999, Food and Drugs Administration (FDA) granted the use of nanoparticles in commercial sunscreen [5].…”

Section: Introductionmentioning

confidence: 99%

Phytolatex synthesized gold nanoparticles as novel agent to enhance sun protection factor of commercial sunscreens

Borase

Salunkhe

Suryawanshi

et al. 2014

Intern J of Cosmetic Sci

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“…This finding is in good agreement with other studies showing that SPF of TiO2 NPs is higher than micro-TiO2. 9 This is due to ability of very small particles in scattering shorter wavelengths of light. 26 Furthermore, as previous studies shows, 10 increasing the concentration of nano-TiO2 made the UV absorbance value higher.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a Model Nano-TiO2 Sunscreen Preparation as a Function of Ingredients Concentration and Ultrasonication Treatment

Hosseinzadeh¹,

Baharifar²,

Amani³

2017

Pharm Sci

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Enhanced sun protection of nano‐sized metal oxide particles over conventional metal oxide particles: An in vitro comparative study

Abstract: Good texture, better spreadability and enhanced in vitro SPF proved the advantageous role of nanoparticles in cosmetics.

Cited by 79 publications

References 12 publications

Role of fatty acid composites in the toxicity of titanium dioxide nanoparticles used in cosmetic products

Role of fatty acid composites in the toxicity of titanium dioxide nanoparticles used in cosmetic products

Phytolatex synthesized gold nanoparticles as novel agent to enhance sun protection factor of commercial sunscreens

Efficacy of a Model Nano-TiO2 Sunscreen Preparation as a Function of Ingredients Concentration and Ultrasonication Treatment

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