Enhanced Structural Stability and Controlled Drug Release of Hydrophilic Antibiotic-Loaded Alginate/Soy Protein Isolate Core-Sheath Fibers for Tissue Engineering Applications

Chuysinuan, Piyachat; Pengsuk, Chalinan; Lirdprapamongkol, Kriengsak; Techasakul, Supanna; Svasti, Jisnuson; Nooeaid, Patcharakamon

doi:10.1007/s12221-019-8753-y

Cited by 31 publications

(13 citation statements)

References 38 publications

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“…Today, nanomaterials play one of the most important roles in the research and development of modern pharmaceutics [1,2,3]. New material processing procedures [4,5,6,7,8], combined with different kinds of raw materials [9,10,11,12,13] and novel innovative strategies for constructing functional products [14,15,16,17,18], are frequently introduced into this application field for providing efficacious drug delivery and enhancing the therapeutic effects of active pharmaceutical ingredients (APIs). Among them, electrohydrodynamic atomization (EHDA) is a popular technique for creating nanoproducts, which mainly includes electrospraying and electrospinning.…”

Section: Introductionmentioning

confidence: 99%

The Process–Property–Performance Relationship of Medicated Nanoparticles Prepared by Modified Coaxial Electrospraying

Huang

Hou

et al. 2019

Pharmaceutics

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In pharmaceutical nanotechnology, the intentional manipulation of working processes to fabricate nanoproducts with suitable properties for achieving the desired functional performances is highly sought after. The following paper aims to detail how a modified coaxial electrospraying has been developed to create ibuprofen-loaded hydroxypropyl methylcellulose nanoparticles for improving the drug dissolution rate. During the working processes, a key parameter, i.e., the spreading angle of atomization region (θ, °), could provide a linkage among the working process, the property of generated nanoparticles and their functional performance. Compared with the applied voltage (V, kV; D = 2713 − 82V with RθV2 = 0.9623), θ could provide a better correlation with the diameter of resultant nanoparticles (D, nm; D = 1096 − 5θ with RDθ2 = 0.9905), suggesting a usefulness of accurately predicting the nanoparticle diameter. The drug released from the electrosprayed nanoparticles involved both erosion and diffusion mechanisms. A univariate quadratic equation between the time of releasing 95% of the loaded drug (t, min) and D (t = 38.7 + 0.097D − 4.838 × 105D2 with a R2 value of 0.9976) suggests that the nanoparticle diameter has a profound influence on the drug release performance. The clear process-property-performance relationship should be useful for optimizing the electrospraying process, and in turn for achieving the desired medicated nanoparticles.

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Section: Introductionmentioning

confidence: 99%

The Process–Property–Performance Relationship of Medicated Nanoparticles Prepared by Modified Coaxial Electrospraying

Huang

Hou

et al. 2019

Pharmaceutics

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“…Isolates from soy protein contain several functional groups that can interact with the surrounding environment, making them useful for several applications like pollutant filtering [61], adhesives [60] and inhibiting oxidation [62]. In general applications, soy proteins are often used in tissue engineering [63,64] and have been used to create microcapsules [65]. Since soy proteins and isolates from soy proteins lack the mechanical integrity of other proteins, researchers often create composites with more mechanically stable polymers in order to create strong biomaterials with the application potential of soy.…”

Section: Soy Proteinsmentioning

confidence: 99%

Protein and Polysaccharide-Based Fiber Materials Generated from Ionic Liquids: A Review

et al. 2020

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Natural biomacromolecules such as structural proteins and polysaccharides are composed of the basic building blocks of life: amino acids and carbohydrates. Understanding their molecular structure, self-assembly and interaction in solvents such as ionic liquids (ILs) is critical for unleashing a flora of new materials, revolutionizing the way we fabricate multi-structural and multi-functional systems with tunable physicochemical properties. Ionic liquids are superior to organic solvents because they do not produce unwanted by-products and are considered green substitutes because of their reusability. In addition, they will significantly improve the miscibility of biopolymers with other materials while maintaining the mechanical properties of the biopolymer in the final product. Understanding and controlling the physicochemical properties of biopolymers in ionic liquids matrices will be crucial for progress leading to the ability to fabricate robust multi-level structural 1D fiber materials. It will also help to predict the relationship between fiber conformation and protein secondary structures or carbohydrate crystallinity, thus creating potential applications for cell growth signaling, ionic conductivity, liquid diffusion and thermal conductivity, and several applications in biomedicine and environmental science. This will also enable the regeneration of biopolymer composite fiber materials with useful functionalities and customizable options critical for additive manufacturing. The specific capabilities of these fiber materials have been shown to vary based on their fabrication methods including electrospinning and post-treatments. This review serves to provide basic knowledge of these commonly utilized protein and polysaccharide biopolymers and their fiber fabrication methods from various ionic liquids, as well as the effect of post-treatments on these fiber materials and their applications in biomedical and pharmaceutical research, wound healing, environmental filters and sustainable and green chemistry research.

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“…These controlled-release profiles include immediate release [ 22 ], pulsatile release [ 23 ], sustained release [ 24 ], multiple-phase release [ 25 ], dual-stage release [ 26 ], extended release [ 27 ], delayed release [ 28 ], topical release [ 29 ], targeted release [ 30 ], and so on. These release profiles are mainly realized by the electrospinnable polymers’ physical and chemical properties [ 31 ], and also by the multiple-compartment structures such as core–shell, Janus, and their combinations [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Core–Shell Eudragit S100 Nanofibers Prepared via Triaxial Electrospinning to Provide a Colon-Targeted Extended Drug Release

et al. 2020

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In this study, a new modified triaxial electrospinning is implemented to generate an Eudragit S100 (ES100)-based core–shell structural nanofiber (CSF), which is loaded with aspirin. The CSFs have a straight line morphology with a smooth surface, an estimated average diameter of 740 ± 110 nm, and a clear core–shell structure with a shell thickness of 65 nm, as disclosed by the scanning electron microscopy and transmission electron microscopy results. Compared to the monolithic composite nanofibers (MCFs) produced using traditional blended single-fluid electrospinning, aspirin presented in both of them amorously owing to their good compatibility. The CSFs showed considerable advantages over the MCFs in providing the desired drug-controlled-release profiles, although both of them released the drug in an erosion mechanism. The former furnished a longer time period of time-delayed-release and a smaller portion released during the first two-hour acid condition for protecting the stomach membranes, and also showed a longer time period of aspirin-extended-release for avoiding possible drug overdose. The present protocols provide a polymer-based process-nanostructure-performance relationship to optimize the reasonable delivery of aspirin.

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Enhanced Structural Stability and Controlled Drug Release of Hydrophilic Antibiotic-Loaded Alginate/Soy Protein Isolate Core-Sheath Fibers for Tissue Engineering Applications

Cited by 31 publications

References 38 publications

The Process–Property–Performance Relationship of Medicated Nanoparticles Prepared by Modified Coaxial Electrospraying

The Process–Property–Performance Relationship of Medicated Nanoparticles Prepared by Modified Coaxial Electrospraying

Protein and Polysaccharide-Based Fiber Materials Generated from Ionic Liquids: A Review

Core–Shell Eudragit S100 Nanofibers Prepared via Triaxial Electrospinning to Provide a Colon-Targeted Extended Drug Release

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