Enhanced stability of vitamin A palmitate microencapsulated by γ-cyclodextrin metal-organic frameworks

Zhang, Guoqing; Meng, Fanyue; Guo, Zhen; Guo, Tao; Peng, Hui; Xiao, Jian; Liu, Botao; Singh, Vikramjeet; Gui, Shuangying; York, Peter; Qian, Wei; Wu, Li; Zhang, Jiwen

doi:10.1080/02652048.2018.1462417

Cited by 54 publications

(30 citation statements)

References 31 publications

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“…Recently, a number of reports on CD-MOF as a promising drug carrier have emerged to load valsartan 33 , folic acid 34 , sucralose 35 , leflunomide 36 , resveratrol 37 , ibuprofen 38 and lansoprazole 39 . However, most of these studies have focused on enhancing the solubility, stability and bioavailability of drugs 40 , 41 . It is noteworthy that budesonide has been reported being encapsulated in the pores of CD-MOF as a new inhalers of pulmonary drug delivery due to its uniform inhalation size 42 .…”

Section: Introductionmentioning

confidence: 99%

Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery

Zhao

Guo

Wang

et al. 2020

Acta Pharmaceutica Sinica B

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It is essential to develop new carriers for laryngeal drug delivery in light of the lack of therapy in laryngeal related diseases. When the inhalable micron-sized crystals of γ -cyclodextrin metal-organic framework (CD-MOF) was utilized as dry powder inhalers (DPIs) carrier with high fine particle fraction (FPF), it was found in this research that the encapsulation of a glycoside compound, namely, scutellarin (SCU) in CD-MOF could significantly enhance its laryngeal deposition. Firstly, SCU loading into CD-MOF was optimized by incubation. Then, a series of characterizations were carried out to elucidate the mechanisms of drug loading. Finally, the laryngeal deposition rate of CD-MOF was 57.72 ± 2.19% improved by SCU, about two times higher than that of CD-MOF, when it was determined by Next Generation Impactor (NGI) at 65 L/min. As a proof of concept, pharyngolaryngitis therapeutic agent dexamethasone (DEX) had improved laryngeal deposition after being co-encapsulated with SCU in CD-MOF. The molecular simulation demonstrated the configuration of SCU in CD-MOF and its contribution to the free energy of the SCU@CD-MOF, which defined the enhanced laryngeal anchoring. In conclusion, the glycosides-like SCU could effectively enhance the anchoring of CD-MOF particles to the larynx to facilitate the treatment of laryngeal diseases.

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Section: Introductionmentioning

confidence: 99%

Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery

Zhao

Guo

Wang

et al. 2020

Acta Pharmaceutica Sinica B

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“…[235] Further study employed γ-CD-MOFs to encapsulate vitamin A palmitate (VAP) with a loading capability of 9.77%, and found that the loaded VAP in γ-CD-MOFs without addition of any antioxidants showed a better stability with 1.6-fold extended half-life compared to that of a best available reference product. [237] Recently, various CD-MOFs through the coordination linking of α-CD [K3(C36H60O30)2•7H2O] and β-CD [(C42O35H70)2 (NaOH)4•H2O] with metal ions were synthesized and revealed similar geometrical structures, which have been applied not only in food packaging, but also in drug delivery, sensor, CO2 capture, insecticide, and separation fields. [80] Lactate is another ligand resource for synthesizing foodgrade MOF, which has been applied in developing safe pesticide formulas.…”

Section: Food-grade Mofsmentioning

confidence: 99%

Metal-organic Framework-based Materials: Synthesis, Stability and Applications in Food Safety and Preservation

Nong¹,

Liu²,

Wang³

et al. 2020

ES Food Agroforest

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Investigation on food safety and preservation is essential to provide high quality and safe food for human beings, including accurate determination and efficient removal of inorganic heavy metal ions and organic contaminants, as well as regulation of food postharvest ripening and intelligent sterilization. In the last two decades, metal-organic frameworks (MOFs), as functionalized porous materials, have aroused interests of researchers because of their advantages of high porosity, large specific surface area, flexible structure properties, and abundant binding sites for guest molecules. MOFs have shown great potentials in practical applications in food and related fields. In this overview, we summarized the MOF crystallization mechanisms, synthesis routes and methods, stability, as well as the applications in food contamination including removal of heavy metal ions, dyes, and antibiotics, and food preservation including regulation of fruit and vegetable ripening, removal of moisture and oxygen, and high-efficiency sterilization. Finally, two perspectives focusing on the development of MOFs for innovative food research, i.e., food-grade MOFs and MOF composites are suggested based on our understanding.

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“…Hingga saat ini, kasus defisiensi vitamin A merupakan salah satu masalah gizi yang perlu mendapat perhatian. Data yang dilaporkan oleh Imdad, et al (2010) (Sumardjo, 2009 (Zhang et al, 2018). Hasil pewarnaan oleh sudan III pada kedua sediaan dibandingkan (Rasaputri, 2010).…”

Section: Pendahuluanunclassified

FORMULASI DAN KARAKTERISASI SEDIAAN NANOEMULSI VITAMIN A <br><i>[Formulation and Characterization of Vitamin A Nanoemulsion]</i>

Adi

Setiawaty

Anindya

et al. 2019

MGI

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Vitamin A is an essential nutrient to support the function of vision, growth, and immune system. Vitamin A cannot be synthesized in the body hence must be obtained through foods or supplements. However, oral administration of vitamin A is often hindered by poor absorption due to its hydrophobic nature and by its easily degradable nature by light and oxygen, particularly at high temperature. This study aimed to prepare a self-assembly vitamin A nanoemulsion with a high loading capacity to improve vitamin A absorption accross intestinal mucosa and to slow down its degradation process. The nanoemulsion was composed by glyceryl monooleate, Cremophor RH-40, and PEG 400 (1:8:1), then titrated with aqueous phase. The nanoemulsion characterization included globule size evaluation, size distribution, zeta potential, globule morphology, entrapment efficiency, physical and chemical stabilities, and ex vivo penetration test on New Zealand albino rabbit intestines. The vitamin A nanoemulsion was found to form transparent and nano-sized emulsions even when loaded with 16.67% vitamin A. The formula also produced 58.1±2.0 nm spherical globules with -0.69 mV zeta potential. Entrapment efficiency of vitamin A in the nanoemulsion was higher than 95%. The nanoemulsion shows stable after storage for 10 days at room temperature, as well as able to increase penetration rate compared to free vitamin A. Taken together, our established vitamin A nanoemulsion has a good stability and was proved to increase vitamin A absorption through intestinal mucosa while simultaneously decreased the vitamin A degradation rate.

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Enhanced stability of vitamin A palmitate microencapsulated by γ-cyclodextrin metal-organic frameworks

Cited by 54 publications

References 31 publications

Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery

Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery

Metal-organic Framework-based Materials: Synthesis, Stability and Applications in Food Safety and Preservation

FORMULASI DAN KARAKTERISASI SEDIAAN NANOEMULSI VITAMIN A <br><i>[Formulation and Characterization of Vitamin A Nanoemulsion]</i>

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