Enhanced Stability of Ramipril in Nanoemulsion Containing Cremophor-EL: A Technical Note

Sheikh, Saifuddin; Shakeel, Faiyaz

doi:10.1208/s12249-008-9151-8

Cited by 42 publications

(20 citation statements)

References 16 publications

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“…The pH of the nanoemulsion at the preparation step can affect the stability of the therapeutic drug and other excipients. Shafiq et al for example reported that Ramipril, a hypertensive drug, is sensitive to moisture and alkaline pH, and nanoemulsion formulation therefore has to be prepared at an acidic pH (5.0) to ensure drug encapsulation in its effective form (92). Similarly, post-formulation pH changes due to oxidation of oil can significantly change the physical parameters of the system.…”

Section: Phmentioning

confidence: 99%

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

et al. 2014

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Abstract. Nanoemulsion dosage form serves as a vehicle for the delivery of active pharmaceutical ingredients and has attracted great attention in drug delivery and pharmacotherapy. In particular, nanoemulsions act as an excellent vehicle for poorly aqueous soluble drugs, which are otherwise difficult to formulate in conventional dosage forms. Nanoemulsions are submicron emulsions composed of generally regarded as safe grade excipients. Particle size at the nanoscale and larger surface area lead to some very interesting physical properties that can be exploited to overcome anatomical and physiological barriers associated in drug delivery to the complex diseases such as cancer. Along these lines, nanoemulsions have been engineered with specific attributes such as size, surface charge, prolonged blood circulation, target specific binding ability, and imaging capability. These attributes can be tuned to assist in delivering drug/imaging agents to the specific site of interest, based on active and passive targeting mechanisms. This review focuses on the current state of nanoemulsions in the translational research and its role in targeted cancer therapy. In addition, the production, physico-chemical characterization, and regulatory aspects of nanoemulsion are addressed.

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Section: Phmentioning

confidence: 99%

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

et al. 2014

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“…Distilled water was used as an aqueous phase. Thereafter, the existence zones of microemulsion were determined by constructing Pseudo Ternary Phase Diagrams (XLSTAT-Pro) using water titration method (Zhang and Kohn, 2011)where surfactant and co surfactant (S mix ) were taken in different ratios (1:0, 1:1, 1:2, 1:3, 1:4, 1:5 and 1:6 ) along with sixteen different combinations of oil and S mix (1:9, 1:8, 1:7, 1:6, 1:5 1:4, 1:3.5, 1:3, 3:7, 1:2, 4:6, 5:5, 6:4, 7:3, 8:2, and 9:1) (Syed, Peh, 2014 andShafiq, Shakeel 2008), after this, the physical state of microemulsion was marked on a pseudo ternary phase diagrams with one axis representing the aqueous phase, second representing oil, and the third representing a mixture of surfactant and co surfactant at fixed S mix ratio.…”

Section: Phase Studiesmentioning

confidence: 99%

Development, characterization and cytotoxicity evaluation of Gingko biloba extract (EGB761) loaded microemulsion for intra-nasal application

Singh¹,

Singh²,

Rachana³

2017

J App Pharm Sci

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Background: Ginkgo biloba is therapeutically important fossil species with extended benefits against CNS disorders as; it contains various potential constituents which are known for their specific actions. In spite of this fact its medicinal usage are limited due to the limited absorption, rapid elimination, vigorous biotransformation and low bioavailability of its therapeutic components. Objective: The present study is an attempt to develop a microemulsion system of standardized extract of Ginkgo biloba (EGB761) for intranasal application. Material and methods: It is developed by water titration method using Isopropyl Myristate (oil), Tween 80 (surfactant) and Ethanol (co surfactant). Results: EGB761 loaded microemulsions were developed and characterized. The optimized formulation showed particle size of 259.8 ± 6.3 nm, PDI score of 0.186 ± 0.092 and zeta potential as -9.87 ± 2.23 mv. Also, TEM images showed size range from 84 -260 nm with smooth and spherical morphology. In vitro phyto-constituents release through isolated nasal mucosa showed release pattern of zero order kinetics with sustained release (up to 16 hours). Moreover, cytotoxicity evaluation (RPMI2650 cell lines) didn't show cytotoxicity for both GBME (99.3 % ± 2.28 % and 98.17 % ± 1.86%) and plain EGB761 extract (95.3 % ± 2.1 and 91.7 % ± 1.07) with different time periods (3 and 12 hours). Conclusion: Therefore, it has been concluded from the results that, EGB761 based microemulsion (GBME) is developed with particle size range between 84 -260 nm, having zero order release kinetics. GBME is found to be safe on RPMI2650 cell line and can be further, investigated in in vivo system.

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“…Thermodynamic stability studies: The formulations were exposed to the subsequent stability studies [19]. A.…”

Section: Evaluation Of Nanoemulsionmentioning

confidence: 99%

Artesunate Loaded Self Nanoemulsified Drug Delivery System: A Preliminary Study for Improved Efficacy in the Treatment of Malaria: Formulation, Characterization and Bio-Distribution Study

R¹

2017

J Bioequiv Availab

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Enhanced Stability of Ramipril in Nanoemulsion Containing Cremophor-EL: A Technical Note

Cited by 42 publications

References 16 publications

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

Development, characterization and cytotoxicity evaluation of Gingko biloba extract (EGB761) loaded microemulsion for intra-nasal application

Artesunate Loaded Self Nanoemulsified Drug Delivery System: A Preliminary Study for Improved Efficacy in the Treatment of Malaria: Formulation, Characterization and Bio-Distribution Study

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