Enhanced stability and controlled release of menthol using a β-cyclodextrin metal-organic framework

Hu, Ziman; Shao, Miao; Zhang, Bin; Fu, Xiong; Huang, Qiang

doi:10.1016/j.foodchem.2021.131760

Cited by 37 publications

(22 citation statements)

References 38 publications

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Section: Drug Delivery Applicationsmentioning

confidence: 99%

“…In another study, Hu et al ( 2022b ) evaluated the dominant parameters of the menthol capacity and the encapsulation efficiency of menthol within the β-cyclodextrin-based metal–organic framework. Hu et al ( 2022b ) recorded that increasing the encapsulation temperature from 65 to 90 ℃ enhanced the menthol capacity from 8 to 21.7% and the encapsulation efficiency from 6.3 to 23.6%, respectively. However, further increases in encapsulation temperature over 90 ℃ dwindled both encapsulation efficiency and menthol capacity (Hu et al 2022b ).…”

Section: Potential Applications Of Cyclodextrin-based Metal–organic F...mentioning

confidence: 99%

“…Hu et al ( 2022b ) recorded that increasing the encapsulation temperature from 65 to 90 ℃ enhanced the menthol capacity from 8 to 21.7% and the encapsulation efficiency from 6.3 to 23.6%, respectively. However, further increases in encapsulation temperature over 90 ℃ dwindled both encapsulation efficiency and menthol capacity (Hu et al 2022b ). The appropriate encapsulation temperature can explain these findings and acquires the menthol molecules more energy that facilitates interactions with the β-cyclodextrin-based metal–organic framework, thereby increasing the menthol capacity and encapsulation efficiency.…”

Section: Potential Applications Of Cyclodextrin-based Metal–organic F...mentioning

confidence: 99%

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Synthesis and potential applications of cyclodextrin-based metal–organic frameworks: a review

et al. 2022

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Metal–organic frameworks are porous polymeric materials formed by linking metal ions with organic bridging ligands. Metal–organic frameworks are used as sensors, catalysts for organic transformations, biomass conversion, photovoltaics, electrochemical applications, gas storage and separation, and photocatalysis. Nonetheless, many actual metal–organic frameworks present limitations such as toxicity of preparation reagents and components, which make frameworks unusable for food and pharmaceutical applications. Here, we review the structure, synthesis and properties of cyclodextrin-based metal–organic frameworks that could be used in bioapplications. Synthetic methods include vapor diffusion, microwave-assisted, hydro/solvothermal, and ultrasound techniques. The vapor diffusion method can produce cyclodextrin-based metal–organic framework crystals with particle sizes ranging from 200 nm to 400 μm. Applications comprise food packaging, drug delivery, sensors, adsorbents, gas separation, and membranes. Cyclodextrin-based metal–organic frameworks showed loading efficacy of the bioactive compounds ranging from 3.29 to 97.80%.

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Section: Drug Delivery Applicationsmentioning

confidence: 99%

Section: Potential Applications Of Cyclodextrin-based Metal–organic F...mentioning

confidence: 99%

Section: Potential Applications Of Cyclodextrin-based Metal–organic F...mentioning

confidence: 99%

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Synthesis and potential applications of cyclodextrin-based metal–organic frameworks: a review

et al. 2022

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“…Li et al [ 29 ] synthesized α-CD-MOF-Na and α-CD-MOF-K to encapsulate ethylene, and it turned out that the encapsulation content of the two CD-MOFs was much higher than that of α-CD and V-type starch. In addition, a higher menthol encapsulated capacity was obtained in β-CD-MOF than pristine β-CD, and menthol/β-CD-MOF-IC is more tolerant to high temperatures [ 30 ]. Moreover, compared with γ-CD, the thymol encapsulation capacity of γ-CD-MOFs generated by potassium salts was increased by two- to three-fold.…”

Section: Introductionmentioning

confidence: 99%

“…It was considered that anions in the preparation solution led to different three-dimensional CD-MOF structures by affecting the symmetry relationship between ions and atoms, thus resulting in different thymol encapsulation contents [ 31 ]. Further investigations on release kinetics also revealed that β-CD-MOF provided menthol with better controlled-release behaviors [ 30 ]. As for the CD-MOFs prepared by three types of cyclodextrins, their differences in thymol encapsulation ability and release behavior are currently unrevealed.…”

Section: Introductionmentioning

confidence: 99%

Controlled Release of Thymol by Cyclodextrin Metal-Organic Frameworks for Preservation of Cherry Tomatoes

Li¹,

Sun

Pan

et al. 2022

Foods

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Thymol is a phenol monoterpene with potential antifungal, antioxidant and antibacterial activities. Due to the low water solubility and high volatility of thymol, encapsulation serves as an effective tool during application. In the present study, cyclodextrin (CD)-based metal-organic-frameworks (MOFs) were synthesized using α-CD, β-CD, and γ-CD as organic building blocks, and further complexed with thymol to produce three CD-MOF-THY inclusion complexes (ICs). The encapsulation content, release kinetics and fruit preservation effect of ICs were analyzed. Results showed that thymol was well embedded in γ-CD-MOFs, with the highest encapsulation content of 286.7 ± 8.4 mg/g. Release kinetics revealed that CD-MOFs exhibited a controlled release effect toward thymol for 35 days. The release kinetics of three ICs fit the Rigter–Peppas model well, with γ-CD-MOF-THY showing the lowest release rate constant of 2.85 at 50 °C, RH 75%. Moreover, γ-CD-MOF-THY exhibited a remarkable preservation performance on cherry tomatoes with the lowest decay index (18.75%) and weight loss (5.17%) after 15 days of storage, suggesting this material as a potential fresh-keeping material for fruit and vegetable preservation.

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Practical Applications of Supramolecular Macrocyclic Hosts in the Field of Herbal Medicines

Yu,

Niu,

Zhao

et al. 2024

Israel Journal of Chemistry

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Herbal medicines (HMs) are gaining increasing popularity and recognition worldwide due to their eco‐friendliness and efficacy. With their multi‐compounds, multi‐targets, and multi‐pathways characteristics, HMs have been used in treatment of various diseases. However, the clinical applications of preparations containing HMs have been limited due to their inherent physicochemical properties, including low water solubility, poor stability, and unsatisfactory bioavailability of bioactive compounds. Supramolecular macrocyclic hosts, like cyclodextrins, calixarenes, cucurbiturils, and pillararenes, are important objects of researches in supramolecular chemistry. These hosts have been utilized to encapsulate the ingredients, improve the solubility of poorly water‐soluble components, enhance the stability of the tested compounds, increase the bioavailability of bioactive compounds, and ensure the safety of HMs. Herein, we provide a brief introduction to the theories of supramolecular chemistry and summarize the extensive applications of supramolecular macrocyclic hosts in the field of HMs. These applications encompass the screening of bioactive compounds in HMs and the enhancement of druggability for HMs. We hope this review can provide a strategy for dealing with the challenges of HMs, thereby enabling their better applications and development.

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Enhanced stability and controlled release of menthol using a β-cyclodextrin metal-organic framework

Cited by 37 publications

References 38 publications

Synthesis and potential applications of cyclodextrin-based metal–organic frameworks: a review

Synthesis and potential applications of cyclodextrin-based metal–organic frameworks: a review

Controlled Release of Thymol by Cyclodextrin Metal-Organic Frameworks for Preservation of Cherry Tomatoes

Practical Applications of Supramolecular Macrocyclic Hosts in the Field of Herbal Medicines

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